Orbital metastasis of renal cell carcinoma masquerading as thyroid ophthalmopathy
Renal cell carcinoma (RCC) is the most common kidney malignancy in adults. However, its presentation with orbital metastasis as the first clinical manifestation is extremely rare and can mimic several other conditions. We report the case of a 72-year-old woman with a history of hyperthyroidism, who...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-04-01
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| Series: | Radiology Case Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S193004332401416X |
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| author | Smrti Aravind, MBBS Dhiran Sivasubramanian, MBBS Sathwik Sanil, MBBS Sharan Prasaanth, MBBS Virushnee Senthilkumar, MBBS |
| author_facet | Smrti Aravind, MBBS Dhiran Sivasubramanian, MBBS Sathwik Sanil, MBBS Sharan Prasaanth, MBBS Virushnee Senthilkumar, MBBS |
| author_sort | Smrti Aravind, MBBS |
| collection | DOAJ |
| description | Renal cell carcinoma (RCC) is the most common kidney malignancy in adults. However, its presentation with orbital metastasis as the first clinical manifestation is extremely rare and can mimic several other conditions. We report the case of a 72-year-old woman with a history of hyperthyroidism, who presented with symptoms resembling thyroid ophthalmopathy. However, magnetic resonance imaging (MRI) of the orbit revealed orbital metastasis. To find the primary tumor, a surveillance computed tomography (CT) was done which showed a mass in the left kidney suggestive of RCC. Histopathological analysis of the mass confirmed clear cell RCC. Early identification of orbital metastases in RCC is crucial, as it may indicate advanced disease. Misdiagnosis due to similarities with other orbital conditions can lead to delayed treatment and suboptimal outcomes. This case highlights the pivotal role of radiological imaging in guiding the diagnosis and management of orbital metastases from RCC. |
| format | Article |
| id | doaj-art-8b6a0f34c8a842fca46feb6532f44d1a |
| institution | OA Journals |
| issn | 1930-0433 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Radiology Case Reports |
| spelling | doaj-art-8b6a0f34c8a842fca46feb6532f44d1a2025-08-20T01:57:52ZengElsevierRadiology Case Reports1930-04332025-04-012041812181510.1016/j.radcr.2024.12.052Orbital metastasis of renal cell carcinoma masquerading as thyroid ophthalmopathySmrti Aravind, MBBS0Dhiran Sivasubramanian, MBBS1Sathwik Sanil, MBBS2Sharan Prasaanth, MBBS3Virushnee Senthilkumar, MBBS4Coimbatore Medical College, Coimbatore, IndiaDepartment of Critical Care Medicine, Christian Medical College, Vellore, India; Corresponding author.Institute of Oncology & Research, Sri Ramakrishna Hospital, Coimbatore, IndiaCoimbatore Medical College, Coimbatore, IndiaCoimbatore Medical College, Coimbatore, IndiaRenal cell carcinoma (RCC) is the most common kidney malignancy in adults. However, its presentation with orbital metastasis as the first clinical manifestation is extremely rare and can mimic several other conditions. We report the case of a 72-year-old woman with a history of hyperthyroidism, who presented with symptoms resembling thyroid ophthalmopathy. However, magnetic resonance imaging (MRI) of the orbit revealed orbital metastasis. To find the primary tumor, a surveillance computed tomography (CT) was done which showed a mass in the left kidney suggestive of RCC. Histopathological analysis of the mass confirmed clear cell RCC. Early identification of orbital metastases in RCC is crucial, as it may indicate advanced disease. Misdiagnosis due to similarities with other orbital conditions can lead to delayed treatment and suboptimal outcomes. This case highlights the pivotal role of radiological imaging in guiding the diagnosis and management of orbital metastases from RCC.http://www.sciencedirect.com/science/article/pii/S193004332401416XRenal cell carcinomaOrbital metastasisClear cell renal cell carcinomaThyroid ophthalmopathyMagnetic resonance imaging (MRI)Palliative radiotherapy |
| spellingShingle | Smrti Aravind, MBBS Dhiran Sivasubramanian, MBBS Sathwik Sanil, MBBS Sharan Prasaanth, MBBS Virushnee Senthilkumar, MBBS Orbital metastasis of renal cell carcinoma masquerading as thyroid ophthalmopathy Radiology Case Reports Renal cell carcinoma Orbital metastasis Clear cell renal cell carcinoma Thyroid ophthalmopathy Magnetic resonance imaging (MRI) Palliative radiotherapy |
| title | Orbital metastasis of renal cell carcinoma masquerading as thyroid ophthalmopathy |
| title_full | Orbital metastasis of renal cell carcinoma masquerading as thyroid ophthalmopathy |
| title_fullStr | Orbital metastasis of renal cell carcinoma masquerading as thyroid ophthalmopathy |
| title_full_unstemmed | Orbital metastasis of renal cell carcinoma masquerading as thyroid ophthalmopathy |
| title_short | Orbital metastasis of renal cell carcinoma masquerading as thyroid ophthalmopathy |
| title_sort | orbital metastasis of renal cell carcinoma masquerading as thyroid ophthalmopathy |
| topic | Renal cell carcinoma Orbital metastasis Clear cell renal cell carcinoma Thyroid ophthalmopathy Magnetic resonance imaging (MRI) Palliative radiotherapy |
| url | http://www.sciencedirect.com/science/article/pii/S193004332401416X |
| work_keys_str_mv | AT smrtiaravindmbbs orbitalmetastasisofrenalcellcarcinomamasqueradingasthyroidophthalmopathy AT dhiransivasubramanianmbbs orbitalmetastasisofrenalcellcarcinomamasqueradingasthyroidophthalmopathy AT sathwiksanilmbbs orbitalmetastasisofrenalcellcarcinomamasqueradingasthyroidophthalmopathy AT sharanprasaanthmbbs orbitalmetastasisofrenalcellcarcinomamasqueradingasthyroidophthalmopathy AT virushneesenthilkumarmbbs orbitalmetastasisofrenalcellcarcinomamasqueradingasthyroidophthalmopathy |