The Significant Therapeutic Effects of Chinese Scorpion: Modern Scientific Exploration of Ion Channels
Chinese scorpion (CS), a traditional animal-based medicine used for over a millennium, has been documented since AD 935–960. It is derived from the scorpion <i>Buthus martensii</i> Karsch and is used to treat various ailments such as stroke, epilepsy, rheumatism, and more. Modern researc...
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MDPI AG
2024-12-01
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| author | Yueyuan Zheng Qiuyi Wen Yushi Huang Dean Guo |
| author_facet | Yueyuan Zheng Qiuyi Wen Yushi Huang Dean Guo |
| author_sort | Yueyuan Zheng |
| collection | DOAJ |
| description | Chinese scorpion (CS), a traditional animal-based medicine used for over a millennium, has been documented since AD 935–960. It is derived from the scorpion <i>Buthus martensii</i> Karsch and is used to treat various ailments such as stroke, epilepsy, rheumatism, and more. Modern research has identified the pharmacological mechanisms behind its traditional uses, with active components like venom and proteins showing analgesic, antitumor, antiepileptic, and antithrombotic effects. Studies reveal that CS affects ion channels, crucial for cellular functions, through interactions with sodium, potassium, and calcium channels, potentially explaining its therapeutic effects. Future research aims to elucidate the precise mechanisms, target specific ion channel subtypes, and validate clinical efficacy and safety, paving the way for novel therapies based on these natural compounds. |
| format | Article |
| id | doaj-art-8b67b6bed2fe4dc4b2ecbaff3fd7528b |
| institution | DOAJ |
| issn | 1424-8247 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceuticals |
| spelling | doaj-art-8b67b6bed2fe4dc4b2ecbaff3fd7528b2025-08-20T02:43:20ZengMDPI AGPharmaceuticals1424-82472024-12-011712173510.3390/ph17121735The Significant Therapeutic Effects of Chinese Scorpion: Modern Scientific Exploration of Ion ChannelsYueyuan Zheng0Qiuyi Wen1Yushi Huang2Dean Guo3School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006, ChinaSchool of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006, ChinaSchool of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006, ChinaSchool of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006, ChinaChinese scorpion (CS), a traditional animal-based medicine used for over a millennium, has been documented since AD 935–960. It is derived from the scorpion <i>Buthus martensii</i> Karsch and is used to treat various ailments such as stroke, epilepsy, rheumatism, and more. Modern research has identified the pharmacological mechanisms behind its traditional uses, with active components like venom and proteins showing analgesic, antitumor, antiepileptic, and antithrombotic effects. Studies reveal that CS affects ion channels, crucial for cellular functions, through interactions with sodium, potassium, and calcium channels, potentially explaining its therapeutic effects. Future research aims to elucidate the precise mechanisms, target specific ion channel subtypes, and validate clinical efficacy and safety, paving the way for novel therapies based on these natural compounds.https://www.mdpi.com/1424-8247/17/12/1735<i>Buthus martensii</i> Karschion channelchemical componentspharmacological effects |
| spellingShingle | Yueyuan Zheng Qiuyi Wen Yushi Huang Dean Guo The Significant Therapeutic Effects of Chinese Scorpion: Modern Scientific Exploration of Ion Channels Pharmaceuticals <i>Buthus martensii</i> Karsch ion channel chemical components pharmacological effects |
| title | The Significant Therapeutic Effects of Chinese Scorpion: Modern Scientific Exploration of Ion Channels |
| title_full | The Significant Therapeutic Effects of Chinese Scorpion: Modern Scientific Exploration of Ion Channels |
| title_fullStr | The Significant Therapeutic Effects of Chinese Scorpion: Modern Scientific Exploration of Ion Channels |
| title_full_unstemmed | The Significant Therapeutic Effects of Chinese Scorpion: Modern Scientific Exploration of Ion Channels |
| title_short | The Significant Therapeutic Effects of Chinese Scorpion: Modern Scientific Exploration of Ion Channels |
| title_sort | significant therapeutic effects of chinese scorpion modern scientific exploration of ion channels |
| topic | <i>Buthus martensii</i> Karsch ion channel chemical components pharmacological effects |
| url | https://www.mdpi.com/1424-8247/17/12/1735 |
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