Effect of the gut microbiome in glaucoma risk from the causal perspective
Objective Evidence from observational studies has reported possible associations between the gut microbiome (GM) and glaucoma. However, the causal effect of GM on glaucoma risk remains to be determined.Methods and analysis We conducted two-sample bidirectional Mendelian randomisation (MR) analyses t...
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BMJ Publishing Group
2024-05-01
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| Series: | BMJ Open Ophthalmology |
| Online Access: | https://bmjophth.bmj.com/content/9/1/e001547.full |
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| author | He Chen Meng Zhou Zicheng Zhang Siqi Bao Jia Qu Yaxuan Wu Ronghua Shi |
| author_facet | He Chen Meng Zhou Zicheng Zhang Siqi Bao Jia Qu Yaxuan Wu Ronghua Shi |
| author_sort | He Chen |
| collection | DOAJ |
| description | Objective Evidence from observational studies has reported possible associations between the gut microbiome (GM) and glaucoma. However, the causal effect of GM on glaucoma risk remains to be determined.Methods and analysis We conducted two-sample bidirectional Mendelian randomisation (MR) analyses to explore the causal association between GM and glaucoma. Genome-wide association study summary statistics of 196 GM taxa (n=18 340) and glaucoma (18 902 cases and 358 375 controls) were obtained from MiBioGen and FinnGen Consortium. Inverse variance weighted, MR-Egger, weighted median, weighted mode, Mendelian Randomisation Pleiotropy Residual Sum and Outlier, MR-Egger intercept and Cochran’s Q statistical analyses were used to supplement MR results and sensitivity analysis. An independent cohort from the Medical Research Council (MRC) Integrative Epidemiology Unit at the University of Bristol (MRC-IEU) Consortium (1715 cases and 359 479 controls) was used to validate causal effects.Results Results of the MR analysis suggested that the family Oxalobacteraceae (OR 0.900, 95% CI 0.843 to 0.961, p=0.002) and the genus Eggerthella (OR 0.881, 95% CI 0.811 to 0.957, p=0.003) had a negative effect on glaucoma, whereas the genus Bilophila (OR 1.202, 95% CI 1.074 to 1.346, p=0.001), LachnospiraceaeUCG010 (OR 1.256, 95% CI 1.109 to 1.423, p=0.0003) and Ruminiclostridium 9 (OR 1.258, 95% CI 1.083 to 1.461, p=0.003) had a positive effect on glaucoma. Among these, the positive causal effect of LachnospiraceaeUCG010 (OR 1.002, 95% CI 1.000 to 1.004, p=0.033) on glaucoma was replicated in an independent cohort.Conclusion This MR analysis from large population studies demonstrated the causal effect of GM on glaucoma risk and supported the role of GM in influencing glaucoma susceptibility. |
| format | Article |
| id | doaj-art-8b677b48594f43e99a03a7b5628473a4 |
| institution | Kabale University |
| issn | 2397-3269 |
| language | English |
| publishDate | 2024-05-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open Ophthalmology |
| spelling | doaj-art-8b677b48594f43e99a03a7b5628473a42025-02-06T10:45:14ZengBMJ Publishing GroupBMJ Open Ophthalmology2397-32692024-05-019110.1136/bmjophth-2023-001547Effect of the gut microbiome in glaucoma risk from the causal perspectiveHe Chen0Meng Zhou1Zicheng Zhang2Siqi Bao3Jia Qu4Yaxuan Wu5Ronghua Shi6National Clinical Research Center for Ocular Diseases, Eye Hospital, Wenzhou Medical University, Wenzhou, People`s Republic of ChinaNational Clinical Research Center for Ocular Diseases, Eye Hospital, Wenzhou Medical University, Wenzhou, People`s Republic of ChinaSchool of Biomedical Engineering, School of Information and Communication Engineering, Hainan University, Haikou, People`s Republic of ChinaSchool of Biomedical Engineering, School of Information and Communication Engineering, Hainan University, Haikou, People`s Republic of ChinaHainan Institute of Real World Data, Qionghai, People`s Republic of ChinaSchool of Biomedical Engineering, School of Information and Communication Engineering, Hainan University, Haikou, People`s Republic of ChinaSchool of Biomedical Engineering, School of Information and Communication Engineering, Hainan University, Haikou, People`s Republic of ChinaObjective Evidence from observational studies has reported possible associations between the gut microbiome (GM) and glaucoma. However, the causal effect of GM on glaucoma risk remains to be determined.Methods and analysis We conducted two-sample bidirectional Mendelian randomisation (MR) analyses to explore the causal association between GM and glaucoma. Genome-wide association study summary statistics of 196 GM taxa (n=18 340) and glaucoma (18 902 cases and 358 375 controls) were obtained from MiBioGen and FinnGen Consortium. Inverse variance weighted, MR-Egger, weighted median, weighted mode, Mendelian Randomisation Pleiotropy Residual Sum and Outlier, MR-Egger intercept and Cochran’s Q statistical analyses were used to supplement MR results and sensitivity analysis. An independent cohort from the Medical Research Council (MRC) Integrative Epidemiology Unit at the University of Bristol (MRC-IEU) Consortium (1715 cases and 359 479 controls) was used to validate causal effects.Results Results of the MR analysis suggested that the family Oxalobacteraceae (OR 0.900, 95% CI 0.843 to 0.961, p=0.002) and the genus Eggerthella (OR 0.881, 95% CI 0.811 to 0.957, p=0.003) had a negative effect on glaucoma, whereas the genus Bilophila (OR 1.202, 95% CI 1.074 to 1.346, p=0.001), LachnospiraceaeUCG010 (OR 1.256, 95% CI 1.109 to 1.423, p=0.0003) and Ruminiclostridium 9 (OR 1.258, 95% CI 1.083 to 1.461, p=0.003) had a positive effect on glaucoma. Among these, the positive causal effect of LachnospiraceaeUCG010 (OR 1.002, 95% CI 1.000 to 1.004, p=0.033) on glaucoma was replicated in an independent cohort.Conclusion This MR analysis from large population studies demonstrated the causal effect of GM on glaucoma risk and supported the role of GM in influencing glaucoma susceptibility.https://bmjophth.bmj.com/content/9/1/e001547.full |
| spellingShingle | He Chen Meng Zhou Zicheng Zhang Siqi Bao Jia Qu Yaxuan Wu Ronghua Shi Effect of the gut microbiome in glaucoma risk from the causal perspective BMJ Open Ophthalmology |
| title | Effect of the gut microbiome in glaucoma risk from the causal perspective |
| title_full | Effect of the gut microbiome in glaucoma risk from the causal perspective |
| title_fullStr | Effect of the gut microbiome in glaucoma risk from the causal perspective |
| title_full_unstemmed | Effect of the gut microbiome in glaucoma risk from the causal perspective |
| title_short | Effect of the gut microbiome in glaucoma risk from the causal perspective |
| title_sort | effect of the gut microbiome in glaucoma risk from the causal perspective |
| url | https://bmjophth.bmj.com/content/9/1/e001547.full |
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