Systematic literature review on the clinical and economic burden of human papillomavirus–related diseases in select areas in the Asia-Pacific region
Compared with Europe and America, adoption of human papillomavirus (HPV) vaccination into national immunization programs across the Asia-Pacific (AP) region has remained low. Moreover, HPV burden in this region has not been reviewed comprehensively. Therefore, this systematic literature review (SLR)...
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Taylor & Francis Group
2024-12-01
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| Series: | Human Vaccines & Immunotherapeutics |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/21645515.2024.2425535 |
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| author | Pei-Jen Lou Wanatpreeya Phongsamart Isaya Sukarom Ying-Hui Wu Omer Zaidi Frieda Du Alyssa Simon Mark Bernauer |
| author_facet | Pei-Jen Lou Wanatpreeya Phongsamart Isaya Sukarom Ying-Hui Wu Omer Zaidi Frieda Du Alyssa Simon Mark Bernauer |
| author_sort | Pei-Jen Lou |
| collection | DOAJ |
| description | Compared with Europe and America, adoption of human papillomavirus (HPV) vaccination into national immunization programs across the Asia-Pacific (AP) region has remained low. Moreover, HPV burden in this region has not been reviewed comprehensively. Therefore, this systematic literature review (SLR) aimed to summarize the clinical and economic burden of HPV and HPV-related diseases in select AP areas. An SLR was conducted January 2000-February 2022 using MEDLINE/Embase. Observational studies reporting incidence, prevalence, costs, or healthcare resource utilization (HCRU) of HPV and HPV-related disease among adults (≥18 years) from select AP areas were included. A total of 254 publications were included. Reported incidence per 100,000 person-years was 15.4–252.0 for cervical cancer (n = 5 publications), 0.2–55.5 for head and neck cancer (n = 7 publications), and 0.2–13.7 for anal cancer (n = 4 publications). Prevalence rates were 9.1%-100% for cervical cancer (n = 40 publications), 0.0%-95.6% for head and neck cancer (n = 48 publications), 0.0%-100% for anal cancer (n = 4 publications), 36.0%-79.6% for penile cancer (n = 4 publications), and 44.0%-82.0% for vaginal/vulvar cancer (n = 3 publications). Few studies reported on costs or HCRU, and high data variability was observed. Despite data variability, the high burden of HPV and HPV-related diseases makes clear the need for effective HPV screening, greater education, and reductions in vaccine hesitancy, particularly among lower- and middle-income areas. Improved data collection measures should be considered in data-scarce areas to better inform policy decision-making and improve monitoring of the impact of HPV vaccination. |
| format | Article |
| id | doaj-art-8b647d29c6304e5e9022ad88ffdd9664 |
| institution | DOAJ |
| issn | 2164-5515 2164-554X |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Human Vaccines & Immunotherapeutics |
| spelling | doaj-art-8b647d29c6304e5e9022ad88ffdd96642025-08-20T03:22:19ZengTaylor & Francis GroupHuman Vaccines & Immunotherapeutics2164-55152164-554X2024-12-0120110.1080/21645515.2024.2425535Systematic literature review on the clinical and economic burden of human papillomavirus–related diseases in select areas in the Asia-Pacific regionPei-Jen Lou0Wanatpreeya Phongsamart1Isaya Sukarom2Ying-Hui Wu3Omer Zaidi4Frieda Du5Alyssa Simon6Mark Bernauer7Department of Otolaryngology, National Taiwan University Hospital and College of Medicine, Taipei City, TaiwanDepartment of Pediatrics, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, ThailandOutcomes Research, Asia Pacific, MSD Thailand, Bangkok, ThailandGlobal Medical and Scientific Affairs, MSD Taiwan, Taipei, TaiwanEvidence & Access, OPEN Health, Bethesda, MD, USAEvidence & Access, OPEN Health, Shanghai, ChinaEvidence & Access, OPEN Health, Bethesda, MD, USAEvidence & Access, OPEN Health, Bethesda, MD, USACompared with Europe and America, adoption of human papillomavirus (HPV) vaccination into national immunization programs across the Asia-Pacific (AP) region has remained low. Moreover, HPV burden in this region has not been reviewed comprehensively. Therefore, this systematic literature review (SLR) aimed to summarize the clinical and economic burden of HPV and HPV-related diseases in select AP areas. An SLR was conducted January 2000-February 2022 using MEDLINE/Embase. Observational studies reporting incidence, prevalence, costs, or healthcare resource utilization (HCRU) of HPV and HPV-related disease among adults (≥18 years) from select AP areas were included. A total of 254 publications were included. Reported incidence per 100,000 person-years was 15.4–252.0 for cervical cancer (n = 5 publications), 0.2–55.5 for head and neck cancer (n = 7 publications), and 0.2–13.7 for anal cancer (n = 4 publications). Prevalence rates were 9.1%-100% for cervical cancer (n = 40 publications), 0.0%-95.6% for head and neck cancer (n = 48 publications), 0.0%-100% for anal cancer (n = 4 publications), 36.0%-79.6% for penile cancer (n = 4 publications), and 44.0%-82.0% for vaginal/vulvar cancer (n = 3 publications). Few studies reported on costs or HCRU, and high data variability was observed. Despite data variability, the high burden of HPV and HPV-related diseases makes clear the need for effective HPV screening, greater education, and reductions in vaccine hesitancy, particularly among lower- and middle-income areas. Improved data collection measures should be considered in data-scarce areas to better inform policy decision-making and improve monitoring of the impact of HPV vaccination.https://www.tandfonline.com/doi/10.1080/21645515.2024.2425535Asia Pacificcostgenotypehealthcare resource utilizationhuman papillomavirusincidence |
| spellingShingle | Pei-Jen Lou Wanatpreeya Phongsamart Isaya Sukarom Ying-Hui Wu Omer Zaidi Frieda Du Alyssa Simon Mark Bernauer Systematic literature review on the clinical and economic burden of human papillomavirus–related diseases in select areas in the Asia-Pacific region Human Vaccines & Immunotherapeutics Asia Pacific cost genotype healthcare resource utilization human papillomavirus incidence |
| title | Systematic literature review on the clinical and economic burden of human papillomavirus–related diseases in select areas in the Asia-Pacific region |
| title_full | Systematic literature review on the clinical and economic burden of human papillomavirus–related diseases in select areas in the Asia-Pacific region |
| title_fullStr | Systematic literature review on the clinical and economic burden of human papillomavirus–related diseases in select areas in the Asia-Pacific region |
| title_full_unstemmed | Systematic literature review on the clinical and economic burden of human papillomavirus–related diseases in select areas in the Asia-Pacific region |
| title_short | Systematic literature review on the clinical and economic burden of human papillomavirus–related diseases in select areas in the Asia-Pacific region |
| title_sort | systematic literature review on the clinical and economic burden of human papillomavirus related diseases in select areas in the asia pacific region |
| topic | Asia Pacific cost genotype healthcare resource utilization human papillomavirus incidence |
| url | https://www.tandfonline.com/doi/10.1080/21645515.2024.2425535 |
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