Exhaled Nitric Oxide is Decreased by Exposure to the Hyperbaric Oxygen Therapy Environment
Exhaled nitric oxide (eNO) detects airway inflammation. Hyperbaric oxygen therapy (HBOT) is used for tissue hypoxia, but can cause lung damage. We measured eNO following inhalation of oxygen at different tensions and pressures. Methods. Part 1, eNO was measured before and after HBOT. Part 2, normal...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2006-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/MI/2006/72620 |
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| _version_ | 1849402266401898496 |
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| author | Zudin A. Puthucheary Jia Liu Michael Bennett Barbara Trytko Sharron Chow Paul S. Thomas |
| author_facet | Zudin A. Puthucheary Jia Liu Michael Bennett Barbara Trytko Sharron Chow Paul S. Thomas |
| author_sort | Zudin A. Puthucheary |
| collection | DOAJ |
| description | Exhaled nitric oxide (eNO) detects airway inflammation. Hyperbaric oxygen therapy (HBOT)
is used for tissue hypoxia, but can cause lung damage. We measured eNO following
inhalation of oxygen at different tensions and pressures. Methods. Part 1, eNO was
measured before and after HBOT. Part 2, normal subjects breathed 40% oxygen. Results.
Baseline eNO levels in patients prior to HBOT exposure were significantly higher than in
normal subjects (P < .05). After HBOT, eNO significantly decreased in patients (15.4 ± 2.0 versus 4.4 ± 0.5 ppb, P < .001), but not in normal subjects, after either 100% O2 at increased pressure
or 40% oxygen, 1 ATA. In an in vitro study, nitrate/nitrite release decreased after 90 minutes HBOT in airway epithelial (A549) cells. Conclusion. HBO exposure causes a fall in eNO. Inducible nitric oxide synthase (iNOS) may cause elevated eNO in patients secondary to inflammation, and inhibition of iNOS may be the mechanism of the reduction of eNO seen with HBOT. |
| format | Article |
| id | doaj-art-8b60bba7a459463cbce837fd22bcf800 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2006-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-8b60bba7a459463cbce837fd22bcf8002025-08-20T03:37:34ZengWileyMediators of Inflammation0962-93511466-18612006-01-01200610.1155/MI/2006/7262072620Exhaled Nitric Oxide is Decreased by Exposure to the Hyperbaric Oxygen Therapy EnvironmentZudin A. Puthucheary0Jia Liu1Michael Bennett2Barbara Trytko3Sharron Chow4Paul S. Thomas5UNSW and Department of Respiratory Medicine, Faculty of Medicine, Prince of Wales Hospital, Randwick 2031, NSW, AustraliaUNSW and Department of Respiratory Medicine, Faculty of Medicine, Prince of Wales Hospital, Randwick 2031, NSW, AustraliaHyperbaric Unit, Prince of Wales Hospital, Randwick 2031, NSW, AustraliaHyperbaric Unit, Prince of Wales Hospital, Randwick 2031, NSW, AustraliaUNSW and Department of Respiratory Medicine, Faculty of Medicine, Prince of Wales Hospital, Randwick 2031, NSW, AustraliaUNSW and Department of Respiratory Medicine, Faculty of Medicine, Prince of Wales Hospital, Randwick 2031, NSW, AustraliaExhaled nitric oxide (eNO) detects airway inflammation. Hyperbaric oxygen therapy (HBOT) is used for tissue hypoxia, but can cause lung damage. We measured eNO following inhalation of oxygen at different tensions and pressures. Methods. Part 1, eNO was measured before and after HBOT. Part 2, normal subjects breathed 40% oxygen. Results. Baseline eNO levels in patients prior to HBOT exposure were significantly higher than in normal subjects (P < .05). After HBOT, eNO significantly decreased in patients (15.4 ± 2.0 versus 4.4 ± 0.5 ppb, P < .001), but not in normal subjects, after either 100% O2 at increased pressure or 40% oxygen, 1 ATA. In an in vitro study, nitrate/nitrite release decreased after 90 minutes HBOT in airway epithelial (A549) cells. Conclusion. HBO exposure causes a fall in eNO. Inducible nitric oxide synthase (iNOS) may cause elevated eNO in patients secondary to inflammation, and inhibition of iNOS may be the mechanism of the reduction of eNO seen with HBOT.http://dx.doi.org/10.1155/MI/2006/72620 |
| spellingShingle | Zudin A. Puthucheary Jia Liu Michael Bennett Barbara Trytko Sharron Chow Paul S. Thomas Exhaled Nitric Oxide is Decreased by Exposure to the Hyperbaric Oxygen Therapy Environment Mediators of Inflammation |
| title | Exhaled Nitric Oxide is Decreased by Exposure to the Hyperbaric Oxygen Therapy Environment |
| title_full | Exhaled Nitric Oxide is Decreased by Exposure to the Hyperbaric Oxygen Therapy Environment |
| title_fullStr | Exhaled Nitric Oxide is Decreased by Exposure to the Hyperbaric Oxygen Therapy Environment |
| title_full_unstemmed | Exhaled Nitric Oxide is Decreased by Exposure to the Hyperbaric Oxygen Therapy Environment |
| title_short | Exhaled Nitric Oxide is Decreased by Exposure to the Hyperbaric Oxygen Therapy Environment |
| title_sort | exhaled nitric oxide is decreased by exposure to the hyperbaric oxygen therapy environment |
| url | http://dx.doi.org/10.1155/MI/2006/72620 |
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