Evolution of tick vaccinology
Ticks represent a major concern for society worldwide. Ticks are also difficult to control, and vaccines represent the most efficacious, safe, economically feasible and environmentally sustainable intervention. The evolution of tick vaccinology has been driven by multiple challenges such as (1) Tick...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Cambridge University Press
2024-08-01
|
| Series: | Parasitology |
| Subjects: | |
| Online Access: | https://www.cambridge.org/core/product/identifier/S003118202400043X/type/journal_article |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832590827549884416 |
|---|---|
| author | José de la Fuente Srikant Ghosh Ala Tabor |
| author_facet | José de la Fuente Srikant Ghosh Ala Tabor |
| author_sort | José de la Fuente |
| collection | DOAJ |
| description | Ticks represent a major concern for society worldwide. Ticks are also difficult to control, and vaccines represent the most efficacious, safe, economically feasible and environmentally sustainable intervention. The evolution of tick vaccinology has been driven by multiple challenges such as (1) Ticks are difficult to control, (2) Vaccines control tick infestations by reducing ectoparasite fitness and reproduction, (3) Vaccine efficacy against multiple tick species, (4) Impact of tick strain genetic diversity on vaccine efficacy, (5) Antigen combination to improve vaccine efficacy, (6) Vaccine formulations and delivery platforms and (7) Combination of vaccines with transgenesis and paratransgenesis. Tick vaccine antigens evolved from organ protein extracts to recombinant proteins to chimera designed by vaccinomics and quantum vaccinomics. Future directions will advance in these areas together with other novel technologies such as multiomics, AI and Big Data, mRNA vaccines, microbiota-driven probiotics and vaccines, and combination of vaccines with other interventions in collaboration with regions with high incidence of tick infestations and tick-borne diseases for a personalized medicine approach. |
| format | Article |
| id | doaj-art-8b5f1e441df544bb88880e69d322971c |
| institution | Kabale University |
| issn | 0031-1820 1469-8161 |
| language | English |
| publishDate | 2024-08-01 |
| publisher | Cambridge University Press |
| record_format | Article |
| series | Parasitology |
| spelling | doaj-art-8b5f1e441df544bb88880e69d322971c2025-01-23T07:11:40ZengCambridge University PressParasitology0031-18201469-81612024-08-011511045105210.1017/S003118202400043XEvolution of tick vaccinologyJosé de la Fuente0https://orcid.org/0000-0001-7383-9649Srikant Ghosh1Ala TaborSaBio. Instituto de Investigación en Recursos Cinegéticos IREC-CSIC-UCLM-JCCM, Ronda de Toledo 12, 13005 Ciudad Real, Spain Department of Veterinary Pathobiology, Center for Veterinary Health Sciences, Oklahoma State University, Stillwater, OK 74078, USAEntomology Laboratory, Parasitology Division, ICAR-Indian Veterinary Research Institute, Izatnagar 243122, Bareilly, UP, India Eastern Regional Station- Indian Veterinary Research Institute, 37 Belgachia Road, Kolkata-700037, West Bengal, IndiaTicks represent a major concern for society worldwide. Ticks are also difficult to control, and vaccines represent the most efficacious, safe, economically feasible and environmentally sustainable intervention. The evolution of tick vaccinology has been driven by multiple challenges such as (1) Ticks are difficult to control, (2) Vaccines control tick infestations by reducing ectoparasite fitness and reproduction, (3) Vaccine efficacy against multiple tick species, (4) Impact of tick strain genetic diversity on vaccine efficacy, (5) Antigen combination to improve vaccine efficacy, (6) Vaccine formulations and delivery platforms and (7) Combination of vaccines with transgenesis and paratransgenesis. Tick vaccine antigens evolved from organ protein extracts to recombinant proteins to chimera designed by vaccinomics and quantum vaccinomics. Future directions will advance in these areas together with other novel technologies such as multiomics, AI and Big Data, mRNA vaccines, microbiota-driven probiotics and vaccines, and combination of vaccines with other interventions in collaboration with regions with high incidence of tick infestations and tick-borne diseases for a personalized medicine approach.https://www.cambridge.org/core/product/identifier/S003118202400043X/type/journal_articleadjuvantsubolesinticktick-borne diseasevaccinevaccinomics |
| spellingShingle | José de la Fuente Srikant Ghosh Ala Tabor Evolution of tick vaccinology Parasitology adjuvant subolesin tick tick-borne disease vaccine vaccinomics |
| title | Evolution of tick vaccinology |
| title_full | Evolution of tick vaccinology |
| title_fullStr | Evolution of tick vaccinology |
| title_full_unstemmed | Evolution of tick vaccinology |
| title_short | Evolution of tick vaccinology |
| title_sort | evolution of tick vaccinology |
| topic | adjuvant subolesin tick tick-borne disease vaccine vaccinomics |
| url | https://www.cambridge.org/core/product/identifier/S003118202400043X/type/journal_article |
| work_keys_str_mv | AT josedelafuente evolutionoftickvaccinology AT srikantghosh evolutionoftickvaccinology AT alatabor evolutionoftickvaccinology |