Effectiveness of ethanol extract of Morinda citrifolia L. as an anti-inflammatory: A preclinical study
The inflammatory response is triggered by infections or tissue damage, often requiring effective anti-inflammatory treatments. Morinda citrifolia L. (noni fruit) contains bioactive compounds such as flavonoids, steroids, and triterpenoids with potential anti-inflammatory properties. The aims of this...
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| Format: | Article |
| Language: | Indonesian |
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Poltekkes Kemenkes Yogyakarta
2024-12-01
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| Series: | Jurnal Teknologi Laboratorium |
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| Online Access: | https://teknolabjournal.com/index.php/Jtl/article/view/493 |
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| author | Mega Hayati Ali Napiah Nasution Ermi Girsang Adek Amansyah Fioni |
| author_facet | Mega Hayati Ali Napiah Nasution Ermi Girsang Adek Amansyah Fioni |
| author_sort | Mega Hayati |
| collection | DOAJ |
| description | The inflammatory response is triggered by infections or tissue damage, often requiring effective anti-inflammatory treatments. Morinda citrifolia L. (noni fruit) contains bioactive compounds such as flavonoids, steroids, and triterpenoids with potential anti-inflammatory properties. The aims of this research to evaluate the anti-inflammatory effects and optimal dosing of ethanol extract of noni fruit in reducing paw edema and improving histopathological conditions in male rats induced with Complete Freund's Adjuvant (CFA). This experimental study involved 30 male rats divided into six groups: normal control, negative control (CFA-only), positive control (triamcinolone 0.72 mg), and three treatment groups receiving noni fruit extract (150, 300, 600 mg/200 g BW). Edema volume was measured using a plethysmometer, and histopathological analysis of joint tissues was conducted. Noni fruit extract significantly reduced edema volume, with 600 mg/200 g BW being the most effective dose. However, histopathological analysis revealed persistent inflammatory cell infiltration and synovial hyperplasia in treated groups, indicating incomplete tissue repair compared to triamcinolone. Ethanol extract of noni fruit demonstrates significant anti-inflammatory effects, particularly at higher doses, but is less effective than triamcinolone in resolving tissue inflammation. |
| format | Article |
| id | doaj-art-8b5be8f753ee48b5a59ae8d1da9bb84e |
| institution | Kabale University |
| issn | 2338-5634 2580-0191 |
| language | Indonesian |
| publishDate | 2024-12-01 |
| publisher | Poltekkes Kemenkes Yogyakarta |
| record_format | Article |
| series | Jurnal Teknologi Laboratorium |
| spelling | doaj-art-8b5be8f753ee48b5a59ae8d1da9bb84e2025-01-03T15:40:12ZindPoltekkes Kemenkes YogyakartaJurnal Teknologi Laboratorium2338-56342580-01912024-12-0113210611610.29238/teknolabjournal.v13i2.493445Effectiveness of ethanol extract of Morinda citrifolia L. as an anti-inflammatory: A preclinical studyMega Hayati0Ali Napiah Nasution1Ermi Girsang2Adek Amansyah3Fioni4Universitas Prima IndonesiaUniversitas Prima IndonesiaDepartment of Biomedical Sciences, Faculty of Medicine, Dentistry, and Health Sciences, Universitas Prima Indonesia, Medan, IndonesiaDepartment of Biomedical Sciences, Faculty of Medicine, Dentistry, and Health Sciences, Universitas Prima Indonesia, Medan, IndonesiaDepartment of Biomedical Sciences, Faculty of Medicine, Dentistry, and Health Sciences, Universitas Prima Indonesia, Medan, IndonesiaThe inflammatory response is triggered by infections or tissue damage, often requiring effective anti-inflammatory treatments. Morinda citrifolia L. (noni fruit) contains bioactive compounds such as flavonoids, steroids, and triterpenoids with potential anti-inflammatory properties. The aims of this research to evaluate the anti-inflammatory effects and optimal dosing of ethanol extract of noni fruit in reducing paw edema and improving histopathological conditions in male rats induced with Complete Freund's Adjuvant (CFA). This experimental study involved 30 male rats divided into six groups: normal control, negative control (CFA-only), positive control (triamcinolone 0.72 mg), and three treatment groups receiving noni fruit extract (150, 300, 600 mg/200 g BW). Edema volume was measured using a plethysmometer, and histopathological analysis of joint tissues was conducted. Noni fruit extract significantly reduced edema volume, with 600 mg/200 g BW being the most effective dose. However, histopathological analysis revealed persistent inflammatory cell infiltration and synovial hyperplasia in treated groups, indicating incomplete tissue repair compared to triamcinolone. Ethanol extract of noni fruit demonstrates significant anti-inflammatory effects, particularly at higher doses, but is less effective than triamcinolone in resolving tissue inflammation.https://teknolabjournal.com/index.php/Jtl/article/view/493noni fruit, complete freund's adjuvant, ethanol extract, anti-inflammatory |
| spellingShingle | Mega Hayati Ali Napiah Nasution Ermi Girsang Adek Amansyah Fioni Effectiveness of ethanol extract of Morinda citrifolia L. as an anti-inflammatory: A preclinical study Jurnal Teknologi Laboratorium noni fruit, complete freund's adjuvant, ethanol extract, anti-inflammatory |
| title | Effectiveness of ethanol extract of Morinda citrifolia L. as an anti-inflammatory: A preclinical study |
| title_full | Effectiveness of ethanol extract of Morinda citrifolia L. as an anti-inflammatory: A preclinical study |
| title_fullStr | Effectiveness of ethanol extract of Morinda citrifolia L. as an anti-inflammatory: A preclinical study |
| title_full_unstemmed | Effectiveness of ethanol extract of Morinda citrifolia L. as an anti-inflammatory: A preclinical study |
| title_short | Effectiveness of ethanol extract of Morinda citrifolia L. as an anti-inflammatory: A preclinical study |
| title_sort | effectiveness of ethanol extract of morinda citrifolia l as an anti inflammatory a preclinical study |
| topic | noni fruit, complete freund's adjuvant, ethanol extract, anti-inflammatory |
| url | https://teknolabjournal.com/index.php/Jtl/article/view/493 |
| work_keys_str_mv | AT megahayati effectivenessofethanolextractofmorindacitrifolialasanantiinflammatoryapreclinicalstudy AT alinapiahnasution effectivenessofethanolextractofmorindacitrifolialasanantiinflammatoryapreclinicalstudy AT ermigirsang effectivenessofethanolextractofmorindacitrifolialasanantiinflammatoryapreclinicalstudy AT adekamansyah effectivenessofethanolextractofmorindacitrifolialasanantiinflammatoryapreclinicalstudy AT fioni effectivenessofethanolextractofmorindacitrifolialasanantiinflammatoryapreclinicalstudy |