Resveratrol attenuates the priapism phenotype in sickle cell mice by restoring NO-cGMP-PDE5 signaling and reducing NADPH oxidase 2 expression

Resveratrol attenuates the priapism phenotype in sickle cell mice by restoring NO-cGMP-PDE5 signaling and reducing NADPH oxidase 2 expression

The pathogenesis of priapism in sickle cell disease (SCD) is closely linked to oxidative stress and reduced bioavailability of nitric oxide (NO) in penile tissue. Resveratrol, a potent natural antioxidant, has demonstrated protective effects in various vascular disorders. To evaluate the therapeutic...

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Main Authors: Carolina Oliveira Splendore, Tammyris Helena Rebecchi Silveira, Dalila Andrade Pereira, Beatriz Pereira Bossarino, Mariana Gonçalves de Oliveira, Fabiano Beraldi Calmasini, Arthur L. Burnett, Fernando Ferreira Costa, Fábio Henrique Silva
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-04-01
Series:Frontiers in Pharmacology
Subjects:
3-nitrotyrosine
cGMP
hemoglobin
reactive oxygen species
corpus cavernosum
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1551533/full
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