Longitudinal association between DNA methylation and type 2 diabetes: findings from the KORA F4/FF4 study

Longitudinal association between DNA methylation and type 2 diabetes: findings from the KORA F4/FF4 study

Abstract Background Type 2 diabetes (T2D) has been linked to changes in DNA methylation levels, which can, in turn, alter transcriptional activity. However, most studies for epigenome-wide associations between T2D and DNA methylation comes from cross-sectional design. Few large-scale investigations...

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Main Authors: Liye Lai, Dave Laurence Juntilla, Monica Del C Gomez-Alonso, Harald Grallert, Barbara Thorand, Aiman Farzeen, Wolfgang Rathmann, Juliane Winkelmann, Holger Prokisch, Christian Gieger, Christian Herder, Annette Peters, Melanie Waldenberger
Format: Article
Language:English
Published: BMC 2025-01-01
Series:Cardiovascular Diabetology
Subjects:
DNA methylation
Type 2 diabetes
Glycemic traits
Diabetes progression
Gene expression
Online Access:https://doi.org/10.1186/s12933-024-02558-8
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