Physiological Changes in the Levels of Anti-Cytokine Autoantibodies in Early Pregnancy Are Missing in Pregnant Women with Hashimoto’s Thyroiditis
T helper type 1 (Th1) and inflammatory cytokines play essential roles in early pregnancy and also in the pathogenesis of Hashimoto’s thyroiditis (HT). Changes in the serum level of autoantibodies to cytokines, which may be able to modulate their availability and actions have been described in severa...
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| Format: | Article |
| Language: | English |
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Wiley
2023-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2023/5221658 |
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| author | Szabina Erdő-Bonyár Diána Simon Anna Bajnok Jasper Nörenberg Tímea Serény-Litvai Ákos Várnagy Kálmán Kovács Eszter Hantosi Emese Mezősi Tímea Berki |
| author_facet | Szabina Erdő-Bonyár Diána Simon Anna Bajnok Jasper Nörenberg Tímea Serény-Litvai Ákos Várnagy Kálmán Kovács Eszter Hantosi Emese Mezősi Tímea Berki |
| author_sort | Szabina Erdő-Bonyár |
| collection | DOAJ |
| description | T helper type 1 (Th1) and inflammatory cytokines play essential roles in early pregnancy and also in the pathogenesis of Hashimoto’s thyroiditis (HT). Changes in the serum level of autoantibodies to cytokines, which may be able to modulate their availability and actions have been described in several autoimmune disorders. Yet, no data are available on anti-cytokine autoantibodies either during early pregnancy or in patients with HT. The aim of the study was to measure autoantibodies to inflammatory-, Th1- and Th22-cytokines in serum samples in healthy pregnancy (HP) and in pregnant women with HT (HTP). As pathological autoantibodies are hallmarks of HT, in addition we also measured anti-B-cell activator factor (BAFF) autoantibodies. The measurement was carried out with a Luminex multiplex assay and the Luminex MAGPIX Instrument, age-matched healthy women (HC) and women with HT (HT) were used as controls. In the first trimester of HP, anti-TNFα, anti-IL-8, and anti-IFNγ autoantibodies were significantly decreased, while autoantibodies to BAFF were significantly elevated compared to the HC. However, these alterations were not present in the HTP. Moreover, the levels of autoantibodies to IL-22 and TNFα were significantly increased in HTP compared to the HP. All differences in the levels of the investigated autoantibodies could be detected in the first trimester of pregnancies except for anti-IL-22 autoantibodies. According to our results we can conclude that alterations in the levels of autoantibodies to inflammatory and Th1 cytokines are physiological in the first trimester of pregnancy and their disturbance can be associated with autoimmune conditions such as HT. |
| format | Article |
| id | doaj-art-8b50b2d4a744490db44bb16d837603dc |
| institution | Kabale University |
| issn | 2314-7156 |
| language | English |
| publishDate | 2023-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-8b50b2d4a744490db44bb16d837603dc2025-08-20T03:37:34ZengWileyJournal of Immunology Research2314-71562023-01-01202310.1155/2023/5221658Physiological Changes in the Levels of Anti-Cytokine Autoantibodies in Early Pregnancy Are Missing in Pregnant Women with Hashimoto’s ThyroiditisSzabina Erdő-Bonyár0Diána Simon1Anna Bajnok2Jasper Nörenberg3Tímea Serény-Litvai4Ákos Várnagy5Kálmán Kovács6Eszter Hantosi7Emese Mezősi8Tímea Berki9Department of Immunology and BiotechnologyDepartment of Immunology and BiotechnologyNational Laboratory on Human ReproductionNational Laboratory on Human ReproductionDepartment of Immunology and BiotechnologyNational Laboratory on Human ReproductionNational Laboratory on Human ReproductionDepartment of Obstetrics and GynecologyNational Laboratory on Human ReproductionDepartment of Immunology and BiotechnologyT helper type 1 (Th1) and inflammatory cytokines play essential roles in early pregnancy and also in the pathogenesis of Hashimoto’s thyroiditis (HT). Changes in the serum level of autoantibodies to cytokines, which may be able to modulate their availability and actions have been described in several autoimmune disorders. Yet, no data are available on anti-cytokine autoantibodies either during early pregnancy or in patients with HT. The aim of the study was to measure autoantibodies to inflammatory-, Th1- and Th22-cytokines in serum samples in healthy pregnancy (HP) and in pregnant women with HT (HTP). As pathological autoantibodies are hallmarks of HT, in addition we also measured anti-B-cell activator factor (BAFF) autoantibodies. The measurement was carried out with a Luminex multiplex assay and the Luminex MAGPIX Instrument, age-matched healthy women (HC) and women with HT (HT) were used as controls. In the first trimester of HP, anti-TNFα, anti-IL-8, and anti-IFNγ autoantibodies were significantly decreased, while autoantibodies to BAFF were significantly elevated compared to the HC. However, these alterations were not present in the HTP. Moreover, the levels of autoantibodies to IL-22 and TNFα were significantly increased in HTP compared to the HP. All differences in the levels of the investigated autoantibodies could be detected in the first trimester of pregnancies except for anti-IL-22 autoantibodies. According to our results we can conclude that alterations in the levels of autoantibodies to inflammatory and Th1 cytokines are physiological in the first trimester of pregnancy and their disturbance can be associated with autoimmune conditions such as HT.http://dx.doi.org/10.1155/2023/5221658 |
| spellingShingle | Szabina Erdő-Bonyár Diána Simon Anna Bajnok Jasper Nörenberg Tímea Serény-Litvai Ákos Várnagy Kálmán Kovács Eszter Hantosi Emese Mezősi Tímea Berki Physiological Changes in the Levels of Anti-Cytokine Autoantibodies in Early Pregnancy Are Missing in Pregnant Women with Hashimoto’s Thyroiditis Journal of Immunology Research |
| title | Physiological Changes in the Levels of Anti-Cytokine Autoantibodies in Early Pregnancy Are Missing in Pregnant Women with Hashimoto’s Thyroiditis |
| title_full | Physiological Changes in the Levels of Anti-Cytokine Autoantibodies in Early Pregnancy Are Missing in Pregnant Women with Hashimoto’s Thyroiditis |
| title_fullStr | Physiological Changes in the Levels of Anti-Cytokine Autoantibodies in Early Pregnancy Are Missing in Pregnant Women with Hashimoto’s Thyroiditis |
| title_full_unstemmed | Physiological Changes in the Levels of Anti-Cytokine Autoantibodies in Early Pregnancy Are Missing in Pregnant Women with Hashimoto’s Thyroiditis |
| title_short | Physiological Changes in the Levels of Anti-Cytokine Autoantibodies in Early Pregnancy Are Missing in Pregnant Women with Hashimoto’s Thyroiditis |
| title_sort | physiological changes in the levels of anti cytokine autoantibodies in early pregnancy are missing in pregnant women with hashimoto s thyroiditis |
| url | http://dx.doi.org/10.1155/2023/5221658 |
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