Gingipain regulates isoform switches of PD-L1 in macrophages infected with Porphyromonas gingivalis

Gingipain regulates isoform switches of PD-L1 in macrophages infected with Porphyromonas gingivalis

Abstract Periodontal pathogen Porphyromonas gingivalis (P. gingivalis) is believed to possess immune evasion capabilities, but it remains unclear whether this immune evasion is related to host gene alternative splicing (AS). In this study, RNA-sequencing revealed significant changes in both AS lands...

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Bibliographic Details
Main Authors: Yilin Zheng, Ziyi Wang, Yao Weng, Heriati Sitosari, Yuhan He, Xiu Zhang, Noriko Shiotsu, Yoko Fukuhara, Mika Ikegame, Hirohiko Okamura
Format: Article
Language:English
Published: Nature Portfolio 2025-03-01
Series:Scientific Reports
Subjects:
Porphyromonas gingivalis
Gingipain
Macrophage
Alternative splicing
PD-L1
Immune evasion
Online Access:https://doi.org/10.1038/s41598-025-94954-7
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