Serious generalized pustular psoriasis with evolution to plaque psoriasis: approach with spesolimab
Generalized pustular psoriasis (GPP) is characterized by an acute and severe variant of psoriasis, often accompanied by systemic symptoms, with the eruption of multiple sterile pustules over an area of erythema, associated or not with the form of plaque psoriasis. Epidemiological data on disease are...
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| Format: | Article |
| Language: | English |
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Sociedade Portuguesa de Dermatologia e Venereologia
2024-10-01
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| Series: | Revista da Sociedade Portuguesa de Dermatologia e Venereologia |
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| Online Access: | https://www.portuguesejournalofdermatology.com/frame_eng.php?id=177 |
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| author | Liz S. Gea Julia C. K. El Dib Omar Algazal Eduardo C.N. Constantino Vera L. A. Nasser João R. Antonio |
| author_facet | Liz S. Gea Julia C. K. El Dib Omar Algazal Eduardo C.N. Constantino Vera L. A. Nasser João R. Antonio |
| author_sort | Liz S. Gea |
| collection | DOAJ |
| description | Generalized pustular psoriasis (GPP) is characterized by an acute and severe variant of psoriasis, often accompanied by systemic symptoms, with the eruption of multiple sterile pustules over an area of erythema, associated or not with the form of plaque psoriasis. Epidemiological data on disease are limited, but a global prevalence is estimated at around 1-7 cases per million people, affecting mainly females, with a higher incidence in the fourth and fifth decades of life. Exacerbations are marked by varying degrees of inflammation and systemic symptoms and have an unpredictable evolution. Hyperactivity of the interleukin-36 (IL-36) inflammatory pathway was discovered as the main pathway responsible for causing the disease. Recently, the active substance spesolimab has shown excellent results in the treatment of GPP, with a mechanism of blocking IL-36 receptor activation, leading to the suppression of pro-inflammatory and profibrotic pathways in inflammatory skin and intestinal diseases.
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| format | Article |
| id | doaj-art-8b4ebf12212544cab6d9ad60d04dc25b |
| institution | DOAJ |
| issn | 2182-2395 2182-2409 |
| language | English |
| publishDate | 2024-10-01 |
| publisher | Sociedade Portuguesa de Dermatologia e Venereologia |
| record_format | Article |
| series | Revista da Sociedade Portuguesa de Dermatologia e Venereologia |
| spelling | doaj-art-8b4ebf12212544cab6d9ad60d04dc25b2025-08-20T02:49:34ZengSociedade Portuguesa de Dermatologia e VenereologiaRevista da Sociedade Portuguesa de Dermatologia e Venereologia2182-23952182-24092024-10-01824Serious generalized pustular psoriasis with evolution to plaque psoriasis: approach with spesolimabLiz S. Gea0Julia C. K. El Dib1Omar Algazal2Eduardo C.N. Constantino3Vera L. A. Nasser4João R. Antonio5Department of Dermatology, Hospital de Base, Faculdade de Medicina de São José do Rio Preto, São José do Rio Preto, São José do Rio Preto, São Paulo, BrazilDepartment of Dermatology, Hospital de Base, Faculdade de Medicina de São José do Rio Preto, São José do Rio Preto, São Paulo, BrazilDepartment of Dermatology and Department of Pathology, Hospital de Base, Faculdade de Medicina de São José do Rio Preto, São José do Rio Preto, São Paulo, BrazilDepartment of Pathology, Hospital de Base, Faculdade de Medicina de São José do Rio Preto. São José do Rio Preto, São Paulo, BrazilDepartment of Dermatology and Department of Pathology, Hospital de Base, Faculdade de Medicina de São José do Rio Preto, São José do Rio Preto, São Paulo, BrazilDepartment of Dermatology and Department of Pathology, Hospital de Base, Faculdade de Medicina de São José do Rio Preto, São José do Rio Preto, São Paulo, BrazilGeneralized pustular psoriasis (GPP) is characterized by an acute and severe variant of psoriasis, often accompanied by systemic symptoms, with the eruption of multiple sterile pustules over an area of erythema, associated or not with the form of plaque psoriasis. Epidemiological data on disease are limited, but a global prevalence is estimated at around 1-7 cases per million people, affecting mainly females, with a higher incidence in the fourth and fifth decades of life. Exacerbations are marked by varying degrees of inflammation and systemic symptoms and have an unpredictable evolution. Hyperactivity of the interleukin-36 (IL-36) inflammatory pathway was discovered as the main pathway responsible for causing the disease. Recently, the active substance spesolimab has shown excellent results in the treatment of GPP, with a mechanism of blocking IL-36 receptor activation, leading to the suppression of pro-inflammatory and profibrotic pathways in inflammatory skin and intestinal diseases. https://www.portuguesejournalofdermatology.com/frame_eng.php?id=177Psoriasis. Pustular psoriasis. Generalized pustular psoriasis. Plaque psoriasis. Spesolimab. Anti interleukin-36. |
| spellingShingle | Liz S. Gea Julia C. K. El Dib Omar Algazal Eduardo C.N. Constantino Vera L. A. Nasser João R. Antonio Serious generalized pustular psoriasis with evolution to plaque psoriasis: approach with spesolimab Revista da Sociedade Portuguesa de Dermatologia e Venereologia Psoriasis. Pustular psoriasis. Generalized pustular psoriasis. Plaque psoriasis. Spesolimab. Anti interleukin-36. |
| title | Serious generalized pustular psoriasis with evolution to plaque psoriasis: approach with spesolimab |
| title_full | Serious generalized pustular psoriasis with evolution to plaque psoriasis: approach with spesolimab |
| title_fullStr | Serious generalized pustular psoriasis with evolution to plaque psoriasis: approach with spesolimab |
| title_full_unstemmed | Serious generalized pustular psoriasis with evolution to plaque psoriasis: approach with spesolimab |
| title_short | Serious generalized pustular psoriasis with evolution to plaque psoriasis: approach with spesolimab |
| title_sort | serious generalized pustular psoriasis with evolution to plaque psoriasis approach with spesolimab |
| topic | Psoriasis. Pustular psoriasis. Generalized pustular psoriasis. Plaque psoriasis. Spesolimab. Anti interleukin-36. |
| url | https://www.portuguesejournalofdermatology.com/frame_eng.php?id=177 |
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