ADVANCED HODGKIN LYMPHOMA: A NEW ERA OF THERAPY
Therapy of advanced Hodgkin lymphoma (HL) is a rapidly changing field due to a lot of currently emerging data. Treatment approaches are presently based on either the Kairos principle of giving aggressive therapy upfront and considering de-escalation of therapy if the interim PET/CT is negative or th...
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| Format: | Article |
| Language: | English |
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PAGEPress Publications
2014-09-01
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| Series: | Mediterranean Journal of Hematology and Infectious Diseases |
| Online Access: | http://www.mjhid.org/index.php/mjhid/article/view/2039 |
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| author | Eldad J Dann |
| author_facet | Eldad J Dann |
| author_sort | Eldad J Dann |
| collection | DOAJ |
| description | Therapy of advanced Hodgkin lymphoma (HL) is a rapidly changing field due to a lot of currently emerging data. Treatment approaches are presently based on either the Kairos principle of giving aggressive therapy upfront and considering de-escalation of therapy if the interim PET/CT is negative or the Chronos principle of starting with ABVD followed by escalation of therapy for patients with positive interim PET/CT. The International Prognostic Score (IPS) is still valid for decision-making regarding the type of initial therapy, since patients with a high score do have an inferior progression free survival (PFS) with ABVD compared to those with a low score. Escalated BEACOPP administered upfront improves PFS; however, increase in the overall survival (OS) has not been confirmed yet, and this therapy is accompanied by elevated toxicity and fertility impairment. Completion of ongoing and currently initiated trials could elucidate multiple issues related to the management of HL patients. |
| format | Article |
| id | doaj-art-8b4e877f04ff449985f612bd2669f5f2 |
| institution | DOAJ |
| issn | 2035-3006 |
| language | English |
| publishDate | 2014-09-01 |
| publisher | PAGEPress Publications |
| record_format | Article |
| series | Mediterranean Journal of Hematology and Infectious Diseases |
| spelling | doaj-art-8b4e877f04ff449985f612bd2669f5f22025-08-20T02:51:59ZengPAGEPress PublicationsMediterranean Journal of Hematology and Infectious Diseases2035-30062014-09-0161e2014063e201406310.4084/mjhid.2014.0631495ADVANCED HODGKIN LYMPHOMA: A NEW ERA OF THERAPYEldad J Dann0JTherapy of advanced Hodgkin lymphoma (HL) is a rapidly changing field due to a lot of currently emerging data. Treatment approaches are presently based on either the Kairos principle of giving aggressive therapy upfront and considering de-escalation of therapy if the interim PET/CT is negative or the Chronos principle of starting with ABVD followed by escalation of therapy for patients with positive interim PET/CT. The International Prognostic Score (IPS) is still valid for decision-making regarding the type of initial therapy, since patients with a high score do have an inferior progression free survival (PFS) with ABVD compared to those with a low score. Escalated BEACOPP administered upfront improves PFS; however, increase in the overall survival (OS) has not been confirmed yet, and this therapy is accompanied by elevated toxicity and fertility impairment. Completion of ongoing and currently initiated trials could elucidate multiple issues related to the management of HL patients.http://www.mjhid.org/index.php/mjhid/article/view/2039 |
| spellingShingle | Eldad J Dann ADVANCED HODGKIN LYMPHOMA: A NEW ERA OF THERAPY Mediterranean Journal of Hematology and Infectious Diseases |
| title | ADVANCED HODGKIN LYMPHOMA: A NEW ERA OF THERAPY |
| title_full | ADVANCED HODGKIN LYMPHOMA: A NEW ERA OF THERAPY |
| title_fullStr | ADVANCED HODGKIN LYMPHOMA: A NEW ERA OF THERAPY |
| title_full_unstemmed | ADVANCED HODGKIN LYMPHOMA: A NEW ERA OF THERAPY |
| title_short | ADVANCED HODGKIN LYMPHOMA: A NEW ERA OF THERAPY |
| title_sort | advanced hodgkin lymphoma a new era of therapy |
| url | http://www.mjhid.org/index.php/mjhid/article/view/2039 |
| work_keys_str_mv | AT eldadjdann advancedhodgkinlymphomaaneweraoftherapy |