Research progress of sarcopenia: Diagnostic advancements, molecular mechanisms, and therapeutic strategies
Muscle atrophy or loss is an important sign of human aging. As the aging society approaches and human lifespan prolongs, sarcopenia has emerged as one of the significant risks influencing the quality of life of the elderly. Sarcopenia is a progressive geriatric syndrome characterized by the deterior...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-09-01
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| Series: | Experimental and Molecular Pathology |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0014480025000425 |
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| author | Hao-lin Wang Long-long Liu Ze-yu Tan Yuan Zhou Jing Zhang Lin Zhai Qian Xie Rong-hua Liu |
| author_facet | Hao-lin Wang Long-long Liu Ze-yu Tan Yuan Zhou Jing Zhang Lin Zhai Qian Xie Rong-hua Liu |
| author_sort | Hao-lin Wang |
| collection | DOAJ |
| description | Muscle atrophy or loss is an important sign of human aging. As the aging society approaches and human lifespan prolongs, sarcopenia has emerged as one of the significant risks influencing the quality of life of the elderly. Sarcopenia is a progressive geriatric syndrome characterized by the deterioration of skeletal muscle mass and function, which can result in an increased risk of falls, fractures, restricted physical activity, disability, mortality, and a remarkable escalation in the risk of cardiovascular diseases among the elderly. This work synthesizes recent advances in sarcopenia research, critically evaluating diagnostic frameworks, histopathological hallmarks, and molecular pathways driving disease progression. Additionally, we provide an in-depth analysis of evidence-based exercise and nutritional interventions, identifying key research gaps. These insights offer valuable references for future research on sarcopenia and clinical management, as well as lifestyle interventions such as exercise and nutrition. |
| format | Article |
| id | doaj-art-8b4b20f088024a6d9e26d19574b87422 |
| institution | Kabale University |
| issn | 1096-0945 |
| language | English |
| publishDate | 2025-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Experimental and Molecular Pathology |
| spelling | doaj-art-8b4b20f088024a6d9e26d19574b874222025-08-20T04:01:02ZengElsevierExperimental and Molecular Pathology1096-09452025-09-0114310499210.1016/j.yexmp.2025.104992Research progress of sarcopenia: Diagnostic advancements, molecular mechanisms, and therapeutic strategiesHao-lin Wang0Long-long Liu1Ze-yu Tan2Yuan Zhou3Jing Zhang4Lin Zhai5Qian Xie6Rong-hua Liu7School of Physical Education, Shaanxi Normal University, Xi'an 710119, ChinaSchool of Physical Education, Shaanxi Normal University, Xi'an 710119, ChinaDepartment of Integrative Biology and Physiology, University of California, Los Angeles, Los Angeles, CA 90095-1606, USASchool of Physical Education, Shaanxi Normal University, Xi'an 710119, ChinaSchool of Physical Education, Shaanxi Normal University, Xi'an 710119, China; Corresponding author.School of Physical Education, Shaanxi Normal University, Xi'an 710119, ChinaSchool of Physical Education, Shaanxi Normal University, Xi'an 710119, ChinaSchool of Physical Education, Shaanxi Normal University, Xi'an 710119, ChinaMuscle atrophy or loss is an important sign of human aging. As the aging society approaches and human lifespan prolongs, sarcopenia has emerged as one of the significant risks influencing the quality of life of the elderly. Sarcopenia is a progressive geriatric syndrome characterized by the deterioration of skeletal muscle mass and function, which can result in an increased risk of falls, fractures, restricted physical activity, disability, mortality, and a remarkable escalation in the risk of cardiovascular diseases among the elderly. This work synthesizes recent advances in sarcopenia research, critically evaluating diagnostic frameworks, histopathological hallmarks, and molecular pathways driving disease progression. Additionally, we provide an in-depth analysis of evidence-based exercise and nutritional interventions, identifying key research gaps. These insights offer valuable references for future research on sarcopenia and clinical management, as well as lifestyle interventions such as exercise and nutrition.http://www.sciencedirect.com/science/article/pii/S0014480025000425SarcopeniaDiagnosticMolecular mechanismsTherapeutic strategiesAging |
| spellingShingle | Hao-lin Wang Long-long Liu Ze-yu Tan Yuan Zhou Jing Zhang Lin Zhai Qian Xie Rong-hua Liu Research progress of sarcopenia: Diagnostic advancements, molecular mechanisms, and therapeutic strategies Experimental and Molecular Pathology Sarcopenia Diagnostic Molecular mechanisms Therapeutic strategies Aging |
| title | Research progress of sarcopenia: Diagnostic advancements, molecular mechanisms, and therapeutic strategies |
| title_full | Research progress of sarcopenia: Diagnostic advancements, molecular mechanisms, and therapeutic strategies |
| title_fullStr | Research progress of sarcopenia: Diagnostic advancements, molecular mechanisms, and therapeutic strategies |
| title_full_unstemmed | Research progress of sarcopenia: Diagnostic advancements, molecular mechanisms, and therapeutic strategies |
| title_short | Research progress of sarcopenia: Diagnostic advancements, molecular mechanisms, and therapeutic strategies |
| title_sort | research progress of sarcopenia diagnostic advancements molecular mechanisms and therapeutic strategies |
| topic | Sarcopenia Diagnostic Molecular mechanisms Therapeutic strategies Aging |
| url | http://www.sciencedirect.com/science/article/pii/S0014480025000425 |
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