Impacts of Oxidative Stress and Antioxidants on Semen Functions
Oxidative stress (OS) has been considered a major contributory factor to the infertility. Oxidative stress is the result of imbalance between the reactive oxygen species (ROS) and antioxidants in the body which can lead to sperm damage, deformity, and eventually male infertility. Although high conce...
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| Format: | Article |
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Wiley
2011-01-01
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| Series: | Veterinary Medicine International |
| Online Access: | http://dx.doi.org/10.4061/2011/686137 |
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| author | Amrit Kaur Bansal G. S. Bilaspuri |
| author_facet | Amrit Kaur Bansal G. S. Bilaspuri |
| author_sort | Amrit Kaur Bansal |
| collection | DOAJ |
| description | Oxidative stress (OS) has been considered a major contributory factor to the infertility. Oxidative stress is the result of imbalance between the reactive oxygen species (ROS) and antioxidants in the body which can lead to sperm damage, deformity, and eventually male infertility. Although high concentrations of the ROS cause sperm pathology (ATP depletion) leading to insufficient axonemal phosphorylation, lipid peroxidation, and loss of motility and viability but, many evidences demonstrate that low and controlled concentrations of these ROS play an important role in sperm physiological processes such as capacitation, acrosome reaction, and signaling processes to ensure fertilization. The supplementation of a cryopreservation extender with antioxidant has been shown to provide a cryoprotective effect on mammalian sperm quality. This paper reviews the impacts of oxidative stress and reactive oxygen species on spermatozoa functions, causes of ROS generation, and antioxidative strategies to reduce OS. In addition, we also highlight the emerging concept of utilizing OS as a tool of contraception. |
| format | Article |
| id | doaj-art-8b4988a1d3e045d2a032937e5a0d8494 |
| institution | Kabale University |
| issn | 2042-0048 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Veterinary Medicine International |
| spelling | doaj-art-8b4988a1d3e045d2a032937e5a0d84942025-08-20T03:37:33ZengWileyVeterinary Medicine International2042-00482011-01-01201110.4061/2011/686137686137Impacts of Oxidative Stress and Antioxidants on Semen FunctionsAmrit Kaur Bansal0G. S. Bilaspuri1Department of Veterinary Gynaecology and Obstetrics, Guru Angad Dev Veterinary and Animal Sciences University, Ludhiana 141004, IndiaDepartment of Veterinary Gynaecology and Obstetrics, Guru Angad Dev Veterinary and Animal Sciences University, Ludhiana 141004, IndiaOxidative stress (OS) has been considered a major contributory factor to the infertility. Oxidative stress is the result of imbalance between the reactive oxygen species (ROS) and antioxidants in the body which can lead to sperm damage, deformity, and eventually male infertility. Although high concentrations of the ROS cause sperm pathology (ATP depletion) leading to insufficient axonemal phosphorylation, lipid peroxidation, and loss of motility and viability but, many evidences demonstrate that low and controlled concentrations of these ROS play an important role in sperm physiological processes such as capacitation, acrosome reaction, and signaling processes to ensure fertilization. The supplementation of a cryopreservation extender with antioxidant has been shown to provide a cryoprotective effect on mammalian sperm quality. This paper reviews the impacts of oxidative stress and reactive oxygen species on spermatozoa functions, causes of ROS generation, and antioxidative strategies to reduce OS. In addition, we also highlight the emerging concept of utilizing OS as a tool of contraception.http://dx.doi.org/10.4061/2011/686137 |
| spellingShingle | Amrit Kaur Bansal G. S. Bilaspuri Impacts of Oxidative Stress and Antioxidants on Semen Functions Veterinary Medicine International |
| title | Impacts of Oxidative Stress and Antioxidants on Semen Functions |
| title_full | Impacts of Oxidative Stress and Antioxidants on Semen Functions |
| title_fullStr | Impacts of Oxidative Stress and Antioxidants on Semen Functions |
| title_full_unstemmed | Impacts of Oxidative Stress and Antioxidants on Semen Functions |
| title_short | Impacts of Oxidative Stress and Antioxidants on Semen Functions |
| title_sort | impacts of oxidative stress and antioxidants on semen functions |
| url | http://dx.doi.org/10.4061/2011/686137 |
| work_keys_str_mv | AT amritkaurbansal impactsofoxidativestressandantioxidantsonsemenfunctions AT gsbilaspuri impactsofoxidativestressandantioxidantsonsemenfunctions |