Metagenomic next-generation sequencing assisted in the successful treatment of pneumonia caused by Talaromyces marneffei in an immunocompetent patient
Introduction: Talaromyces marneffei (T. marneffei), a kind of endemic opportunistic pathogen, was previously thought to occur in HIV-positive individuals and non-HIV hosts with impaired immune function. However, the infection of T. marneffei in patient with normal immune function was rarely reporte...
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The Journal of Infection in Developing Countries
2024-08-01
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| Series: | Journal of Infection in Developing Countries |
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| Online Access: | https://jidc.org/index.php/journal/article/view/19061 |
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| author | Ling-Yan Ye Xu-Ling Zhao Jia-Jia Qin Jian Lin |
| author_facet | Ling-Yan Ye Xu-Ling Zhao Jia-Jia Qin Jian Lin |
| author_sort | Ling-Yan Ye |
| collection | DOAJ |
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Introduction: Talaromyces marneffei (T. marneffei), a kind of endemic opportunistic pathogen, was previously thought to occur in HIV-positive individuals and non-HIV hosts with impaired immune function. However, the infection of T. marneffei in patient with normal immune function was rarely reported.
Case Presentation: We report a case of severe pneumonia caused by T. marneffei in an immunocompetent and HIV-negative patient, which was rapidly confirmed by metagenomics next-generation sequencing (mNGS) and treated successfully. The patient was a previously healthy 63-year-old male, who was admitted to hospital with fever for 11 days, cough and sputum for 1 week, and chest distress for 4 days. The infection of T. marneffei was quickly determined by alveolar lavage under bedside bronchoscope and mNGS test.
Results: Patient’s condition improved rapidly after voriconazole treatment, and he was evaluated as a HIV-negative case of T. marneffei infection with normal immune function. This is a sporadic case of T. marneffei in non-endemic areas, and mNGS played a very important role in the treatment of the disease. The patient’s immune function was relatively normal which was rare in clinical practice.
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| format | Article |
| id | doaj-art-8b470ff29f2b402aad9e680dd5ec1a25 |
| institution | Kabale University |
| issn | 1972-2680 |
| language | English |
| publishDate | 2024-08-01 |
| publisher | The Journal of Infection in Developing Countries |
| record_format | Article |
| series | Journal of Infection in Developing Countries |
| spelling | doaj-art-8b470ff29f2b402aad9e680dd5ec1a252025-08-20T03:52:38ZengThe Journal of Infection in Developing CountriesJournal of Infection in Developing Countries1972-26802024-08-01180810.3855/jidc.19061Metagenomic next-generation sequencing assisted in the successful treatment of pneumonia caused by Talaromyces marneffei in an immunocompetent patientLing-Yan Ye0Xu-Ling Zhao1Jia-Jia Qin2Jian Lin3Department of Respiratory and Critical Care Medicine, Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University, Linhai, Zhejiang, P. R. ChinaGeneral Medical Ward (9A), East Branch, Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University, Linhai, Zhejiang, P. R. ChinaDepartment of Clinical Laboratory, Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University, Linhai, Zhejiang, P. R. ChinaDepartment of Respiratory and Critical Care Medicine, Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University, Linhai, Zhejiang, P. R. China Introduction: Talaromyces marneffei (T. marneffei), a kind of endemic opportunistic pathogen, was previously thought to occur in HIV-positive individuals and non-HIV hosts with impaired immune function. However, the infection of T. marneffei in patient with normal immune function was rarely reported. Case Presentation: We report a case of severe pneumonia caused by T. marneffei in an immunocompetent and HIV-negative patient, which was rapidly confirmed by metagenomics next-generation sequencing (mNGS) and treated successfully. The patient was a previously healthy 63-year-old male, who was admitted to hospital with fever for 11 days, cough and sputum for 1 week, and chest distress for 4 days. The infection of T. marneffei was quickly determined by alveolar lavage under bedside bronchoscope and mNGS test. Results: Patient’s condition improved rapidly after voriconazole treatment, and he was evaluated as a HIV-negative case of T. marneffei infection with normal immune function. This is a sporadic case of T. marneffei in non-endemic areas, and mNGS played a very important role in the treatment of the disease. The patient’s immune function was relatively normal which was rare in clinical practice. https://jidc.org/index.php/journal/article/view/19061Talaromyces marneffeimetagenomic next-generation sequencing (mNGS)immune function |
| spellingShingle | Ling-Yan Ye Xu-Ling Zhao Jia-Jia Qin Jian Lin Metagenomic next-generation sequencing assisted in the successful treatment of pneumonia caused by Talaromyces marneffei in an immunocompetent patient Journal of Infection in Developing Countries Talaromyces marneffei metagenomic next-generation sequencing (mNGS) immune function |
| title | Metagenomic next-generation sequencing assisted in the successful treatment of pneumonia caused by Talaromyces marneffei in an immunocompetent patient |
| title_full | Metagenomic next-generation sequencing assisted in the successful treatment of pneumonia caused by Talaromyces marneffei in an immunocompetent patient |
| title_fullStr | Metagenomic next-generation sequencing assisted in the successful treatment of pneumonia caused by Talaromyces marneffei in an immunocompetent patient |
| title_full_unstemmed | Metagenomic next-generation sequencing assisted in the successful treatment of pneumonia caused by Talaromyces marneffei in an immunocompetent patient |
| title_short | Metagenomic next-generation sequencing assisted in the successful treatment of pneumonia caused by Talaromyces marneffei in an immunocompetent patient |
| title_sort | metagenomic next generation sequencing assisted in the successful treatment of pneumonia caused by talaromyces marneffei in an immunocompetent patient |
| topic | Talaromyces marneffei metagenomic next-generation sequencing (mNGS) immune function |
| url | https://jidc.org/index.php/journal/article/view/19061 |
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