An update on adverse health effects from exposure to PM2.5
The impact of fine particulate matter (PM2.5) on public health has become a global concern due to the mortality and morbidity it entails. Pathophysiological and epidemiological studies have demonstrated an association between PM2.5 and respiratory diseases, cardiovascular diseases, and neurological...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-12-01
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| Series: | Environmental Advances |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666765724001212 |
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| author | Sarawut Sangkham Worradorn Phairuang Samendra P. Sherchan Nattapon Pansakun Narongsuk Munkong Kritsada Sarndhong Md. Aminul Islam Pornpun Sakunkoo |
| author_facet | Sarawut Sangkham Worradorn Phairuang Samendra P. Sherchan Nattapon Pansakun Narongsuk Munkong Kritsada Sarndhong Md. Aminul Islam Pornpun Sakunkoo |
| author_sort | Sarawut Sangkham |
| collection | DOAJ |
| description | The impact of fine particulate matter (PM2.5) on public health has become a global concern due to the mortality and morbidity it entails. Pathophysiological and epidemiological studies have demonstrated an association between PM2.5 and respiratory diseases, cardiovascular diseases, and neurological disorders. The underlying mechanisms through which PM2.5 adversely affects human health include the induction of oxidative stress, cytokine release, deoxyribonucleic acid (DNA) damage, altered gene expression, immune toxicity, inflammatory responses, and apoptosis. These outcomes drive the initiation and progression of various diseases. Notably, exposure to PM2.5 containing chemical compounds may translocate and induce unbalanced intracellular functions at the genetic and epigenetic levels, leading to mutations, carcinogenesis, and multiple diseases. This review aims to summarise and discuss recent updates on the mechanisms linking PM2.5 exposure to adverse health, highlighting the critical connection between PM2.5 and health outcomes, with the hope of raising awareness and promoting measures to reduce PM2.5 levels worldwide. |
| format | Article |
| id | doaj-art-8b3fbfc13856427b99c2521077417248 |
| institution | OA Journals |
| issn | 2666-7657 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Environmental Advances |
| spelling | doaj-art-8b3fbfc13856427b99c25210774172482025-08-20T02:21:01ZengElsevierEnvironmental Advances2666-76572024-12-011810060310.1016/j.envadv.2024.100603An update on adverse health effects from exposure to PM2.5Sarawut Sangkham0Worradorn Phairuang1Samendra P. Sherchan2Nattapon Pansakun3Narongsuk Munkong4Kritsada Sarndhong5Md. Aminul Islam6Pornpun Sakunkoo7Department of Environmental Health, School of Public Health, University of Phayao, Muang District, Phayao 56000, Thailand; Corresponding authors.Faculty of Geosciences and Civil Engineering, Institute of Science and Engineering, Kanazawa University, Kanazawa, Ishikawa 920-1192, Japan; Department of Geography, Faculty of Social Sciences, Chiang Mai University, Muang, Chiang Mai 50200, ThailandDepartment of Environmental Health Sciences, Tulane University, 1440 Canal Street, Suite 2100, New Orleans, LA 70112, USA; Center of Research Excellence in Wastewater based Epidemiology, Morgan State University, Baltimore, MD, USADepartment of Health Promotion, School of Public Health, University of Phayao, Muang District, Phayao 56000, ThailandDepartment of Pathology, School of Medicine, University of Phayao, Muang District, Phayao 56000, ThailandDepartment of Community Health, School of Public Health, University of Phayao, Phayao 56000, ThailandCOVID-19 Diagnostic Lab, Department of Microbiology, Noakhali Science and Technology University, Noakhali 3814, Bangladesh; Advanced Molecular Lab, Department of Microbiology, President Abdul Hamid Medical College, Karimganj, Kishoreganj, BangladeshDepartment of Environmental Health Occupational Health and Safety, Faculty of Public Health, Khon Kaen University, Muang District, Khon Kaen 40002, Thailand; Corresponding authors.The impact of fine particulate matter (PM2.5) on public health has become a global concern due to the mortality and morbidity it entails. Pathophysiological and epidemiological studies have demonstrated an association between PM2.5 and respiratory diseases, cardiovascular diseases, and neurological disorders. The underlying mechanisms through which PM2.5 adversely affects human health include the induction of oxidative stress, cytokine release, deoxyribonucleic acid (DNA) damage, altered gene expression, immune toxicity, inflammatory responses, and apoptosis. These outcomes drive the initiation and progression of various diseases. Notably, exposure to PM2.5 containing chemical compounds may translocate and induce unbalanced intracellular functions at the genetic and epigenetic levels, leading to mutations, carcinogenesis, and multiple diseases. This review aims to summarise and discuss recent updates on the mechanisms linking PM2.5 exposure to adverse health, highlighting the critical connection between PM2.5 and health outcomes, with the hope of raising awareness and promoting measures to reduce PM2.5 levels worldwide.http://www.sciencedirect.com/science/article/pii/S2666765724001212Air pollutionAsthmaCarcinogenesisChronic obstructive pulmonary diseaseDNA methylationFine particulate matter |
| spellingShingle | Sarawut Sangkham Worradorn Phairuang Samendra P. Sherchan Nattapon Pansakun Narongsuk Munkong Kritsada Sarndhong Md. Aminul Islam Pornpun Sakunkoo An update on adverse health effects from exposure to PM2.5 Environmental Advances Air pollution Asthma Carcinogenesis Chronic obstructive pulmonary disease DNA methylation Fine particulate matter |
| title | An update on adverse health effects from exposure to PM2.5 |
| title_full | An update on adverse health effects from exposure to PM2.5 |
| title_fullStr | An update on adverse health effects from exposure to PM2.5 |
| title_full_unstemmed | An update on adverse health effects from exposure to PM2.5 |
| title_short | An update on adverse health effects from exposure to PM2.5 |
| title_sort | update on adverse health effects from exposure to pm2 5 |
| topic | Air pollution Asthma Carcinogenesis Chronic obstructive pulmonary disease DNA methylation Fine particulate matter |
| url | http://www.sciencedirect.com/science/article/pii/S2666765724001212 |
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