Evaluation of combination of ALA-PDT and interferon for cervical low-grade squamous intraepithelial lesion (LSIL)
Background: Cervical LSIL is a precancerous disease which requires regular follow-up. High risk patients need active interventions. Interferon and topical PDT have been used in the treatment of cervical LSIL. The aim of this study was to evaluate the combination use of topical PDT and interferon in...
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Elsevier
2024-02-01
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| Series: | Photodiagnosis and Photodynamic Therapy |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1572100024000061 |
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| author | Sijing Li Min Zhao Ming Luo Jin Wu Zhaoning Duan Xiaoling Huang Shan Lu Qiao Zu Qun Xiao Jia Ying |
| author_facet | Sijing Li Min Zhao Ming Luo Jin Wu Zhaoning Duan Xiaoling Huang Shan Lu Qiao Zu Qun Xiao Jia Ying |
| author_sort | Sijing Li |
| collection | DOAJ |
| description | Background: Cervical LSIL is a precancerous disease which requires regular follow-up. High risk patients need active interventions. Interferon and topical PDT have been used in the treatment of cervical LSIL. The aim of this study was to evaluate the combination use of topical PDT and interferon in the treatment of cervical LSIL. Materials and methods: A prospective study was carried out involving 159 women with cervical LSIL and high risk human papillomaviruses (hr-HPV) infection. Patients were divided into three groups. Group 1-receiving interferon suppository only, Group 2-receiving 19 mg/cm2 ALA plus post PDT interferon, and Group 3-receiving 38 mg/cm2 ALA plus post PDT interferon. The primary endpoint was pathological regression. The secondary endpoints were the HPV negative conversion rate and the adverse effects of treatment. Results: At 6–12 months after PDT, for Group 1, the effective rate, CR rate and HPV negative conversion rate was 48.3 %, 43.3 % and 24.0 %, respectively. For Group 2, the effective rate, CR rate and HPV negative conversion rate were 89.3 %, 71.4 %, and 72.4 %, respectively. For Group 3, the effective rate, CR rate and HPV negative conversion rate were 91.5 %, 66.1 %, and 64.4 %, respectively, significantly higher than those of interferon only group. Two ALA dose group study showed similar efficacy. No patient experienced serious adverse effects. Conclusions: ALA-PDT combined with interferon therapy was feasible and tolerable. Two ALA dose groups showed similar outcomes in treating cervical LSIL. |
| format | Article |
| id | doaj-art-8b3efc0ced7644ec8f4bb2885caacd09 |
| institution | OA Journals |
| issn | 1572-1000 |
| language | English |
| publishDate | 2024-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Photodiagnosis and Photodynamic Therapy |
| spelling | doaj-art-8b3efc0ced7644ec8f4bb2885caacd092025-08-20T01:54:51ZengElsevierPhotodiagnosis and Photodynamic Therapy1572-10002024-02-014510396710.1016/j.pdpdt.2024.103967Evaluation of combination of ALA-PDT and interferon for cervical low-grade squamous intraepithelial lesion (LSIL)Sijing Li0Min Zhao1Ming Luo2Jin Wu3Zhaoning Duan4Xiaoling Huang5Shan Lu6Qiao Zu7Qun Xiao8Jia Ying9Department of Obstetrics and Gynecology, The First Affiliated Hospital of Chongqing Medical University, Yuzhong District, Chongqing 400000, ChinaDepartment of Pathology, The First Affiliated Hospital of Chongqing Medical University, Yuzhong District, Chongqing 400000, ChinaDepartment of Obstetrics and Gynecology, The First Affiliated Hospital of Chongqing Medical University, Yuzhong District, Chongqing 400000, ChinaDepartment of Obstetrics and Gynecology, The First Affiliated Hospital of Chongqing Medical University, Yuzhong District, Chongqing 400000, ChinaDepartment of Obstetrics and Gynecology, The First Affiliated Hospital of Chongqing Medical University, Yuzhong District, Chongqing 400000, ChinaDepartment of Obstetrics and Gynecology, The First Affiliated Hospital of Chongqing Medical University, Yuzhong District, Chongqing 400000, ChinaDepartment of Obstetrics and Gynecology, The First Affiliated Hospital of Chongqing Medical University, Yuzhong District, Chongqing 400000, ChinaDepartment of Obstetrics and Gynecology, The First Affiliated Hospital of Chongqing Medical University, Yuzhong District, Chongqing 400000, ChinaDepartment of Obstetrics and Gynecology, The People's Hospital of Nanchuan, Nanchuan District, Chongqing 408400, ChinaDepartment of Obstetrics and Gynecology, The First Affiliated Hospital of Chongqing Medical University, Yuzhong District, Chongqing 400000, China; Corresponding author.Background: Cervical LSIL is a precancerous disease which requires regular follow-up. High risk patients need active interventions. Interferon and topical PDT have been used in the treatment of cervical LSIL. The aim of this study was to evaluate the combination use of topical PDT and interferon in the treatment of cervical LSIL. Materials and methods: A prospective study was carried out involving 159 women with cervical LSIL and high risk human papillomaviruses (hr-HPV) infection. Patients were divided into three groups. Group 1-receiving interferon suppository only, Group 2-receiving 19 mg/cm2 ALA plus post PDT interferon, and Group 3-receiving 38 mg/cm2 ALA plus post PDT interferon. The primary endpoint was pathological regression. The secondary endpoints were the HPV negative conversion rate and the adverse effects of treatment. Results: At 6–12 months after PDT, for Group 1, the effective rate, CR rate and HPV negative conversion rate was 48.3 %, 43.3 % and 24.0 %, respectively. For Group 2, the effective rate, CR rate and HPV negative conversion rate were 89.3 %, 71.4 %, and 72.4 %, respectively. For Group 3, the effective rate, CR rate and HPV negative conversion rate were 91.5 %, 66.1 %, and 64.4 %, respectively, significantly higher than those of interferon only group. Two ALA dose group study showed similar efficacy. No patient experienced serious adverse effects. Conclusions: ALA-PDT combined with interferon therapy was feasible and tolerable. Two ALA dose groups showed similar outcomes in treating cervical LSIL.http://www.sciencedirect.com/science/article/pii/S1572100024000061Cervical low-grade squamous intraepithelial lesionHigh risk human papillomavirus5-Aminolevulinic acid photodynamic therapyInterferonSILPhotodynamic therapy |
| spellingShingle | Sijing Li Min Zhao Ming Luo Jin Wu Zhaoning Duan Xiaoling Huang Shan Lu Qiao Zu Qun Xiao Jia Ying Evaluation of combination of ALA-PDT and interferon for cervical low-grade squamous intraepithelial lesion (LSIL) Photodiagnosis and Photodynamic Therapy Cervical low-grade squamous intraepithelial lesion High risk human papillomavirus 5-Aminolevulinic acid photodynamic therapy Interferon SIL Photodynamic therapy |
| title | Evaluation of combination of ALA-PDT and interferon for cervical low-grade squamous intraepithelial lesion (LSIL) |
| title_full | Evaluation of combination of ALA-PDT and interferon for cervical low-grade squamous intraepithelial lesion (LSIL) |
| title_fullStr | Evaluation of combination of ALA-PDT and interferon for cervical low-grade squamous intraepithelial lesion (LSIL) |
| title_full_unstemmed | Evaluation of combination of ALA-PDT and interferon for cervical low-grade squamous intraepithelial lesion (LSIL) |
| title_short | Evaluation of combination of ALA-PDT and interferon for cervical low-grade squamous intraepithelial lesion (LSIL) |
| title_sort | evaluation of combination of ala pdt and interferon for cervical low grade squamous intraepithelial lesion lsil |
| topic | Cervical low-grade squamous intraepithelial lesion High risk human papillomavirus 5-Aminolevulinic acid photodynamic therapy Interferon SIL Photodynamic therapy |
| url | http://www.sciencedirect.com/science/article/pii/S1572100024000061 |
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