Optimization and Implication of Adipose-Derived Stem Cells in Craniofacial Bone Regeneration and Repair
Adipose-derived stem cells (ADSCs) have emerged as a promising resource for craniofacial bone regeneration due to their high abundance and easy accessibility, significant osteogenic potential, versatile applications, and potential for personalized medicine, which underscore their importance in this...
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MDPI AG
2024-10-01
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| Series: | Bioengineering |
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| Online Access: | https://www.mdpi.com/2306-5354/11/11/1100 |
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| author | Cong Gu Qinghuang Tang Liwen Li YiPing Chen |
| author_facet | Cong Gu Qinghuang Tang Liwen Li YiPing Chen |
| author_sort | Cong Gu |
| collection | DOAJ |
| description | Adipose-derived stem cells (ADSCs) have emerged as a promising resource for craniofacial bone regeneration due to their high abundance and easy accessibility, significant osteogenic potential, versatile applications, and potential for personalized medicine, which underscore their importance in this field. This article reviews the current progress of preclinical studies that describe the careful selection of specific ADSC subpopulations, key signaling pathways involved, and usage of various strategies to enhance the osteogenic potential of ADSCs. Additionally, clinical case reports regarding the application of ADSCs in the repair of calvarial defects, cranio-maxillofacial defects, and alveolar bone defects are also discussed. |
| format | Article |
| id | doaj-art-8b395c4d4cd643eba11a8190228c9d4d |
| institution | OA Journals |
| issn | 2306-5354 |
| language | English |
| publishDate | 2024-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Bioengineering |
| spelling | doaj-art-8b395c4d4cd643eba11a8190228c9d4d2025-08-20T02:28:01ZengMDPI AGBioengineering2306-53542024-10-011111110010.3390/bioengineering11111100Optimization and Implication of Adipose-Derived Stem Cells in Craniofacial Bone Regeneration and RepairCong Gu0Qinghuang Tang1Liwen Li2YiPing Chen3Department of Cell and Molecular Biology, Tulane University, New Orleans, LA 70118, USADepartment of Cell and Molecular Biology, Tulane University, New Orleans, LA 70118, USADepartment of Cell and Molecular Biology, Tulane University, New Orleans, LA 70118, USADepartment of Cell and Molecular Biology, Tulane University, New Orleans, LA 70118, USAAdipose-derived stem cells (ADSCs) have emerged as a promising resource for craniofacial bone regeneration due to their high abundance and easy accessibility, significant osteogenic potential, versatile applications, and potential for personalized medicine, which underscore their importance in this field. This article reviews the current progress of preclinical studies that describe the careful selection of specific ADSC subpopulations, key signaling pathways involved, and usage of various strategies to enhance the osteogenic potential of ADSCs. Additionally, clinical case reports regarding the application of ADSCs in the repair of calvarial defects, cranio-maxillofacial defects, and alveolar bone defects are also discussed.https://www.mdpi.com/2306-5354/11/11/1100adipose-derived stem cellsADSCscraniofacial bone regeneration |
| spellingShingle | Cong Gu Qinghuang Tang Liwen Li YiPing Chen Optimization and Implication of Adipose-Derived Stem Cells in Craniofacial Bone Regeneration and Repair Bioengineering adipose-derived stem cells ADSCs craniofacial bone regeneration |
| title | Optimization and Implication of Adipose-Derived Stem Cells in Craniofacial Bone Regeneration and Repair |
| title_full | Optimization and Implication of Adipose-Derived Stem Cells in Craniofacial Bone Regeneration and Repair |
| title_fullStr | Optimization and Implication of Adipose-Derived Stem Cells in Craniofacial Bone Regeneration and Repair |
| title_full_unstemmed | Optimization and Implication of Adipose-Derived Stem Cells in Craniofacial Bone Regeneration and Repair |
| title_short | Optimization and Implication of Adipose-Derived Stem Cells in Craniofacial Bone Regeneration and Repair |
| title_sort | optimization and implication of adipose derived stem cells in craniofacial bone regeneration and repair |
| topic | adipose-derived stem cells ADSCs craniofacial bone regeneration |
| url | https://www.mdpi.com/2306-5354/11/11/1100 |
| work_keys_str_mv | AT conggu optimizationandimplicationofadiposederivedstemcellsincraniofacialboneregenerationandrepair AT qinghuangtang optimizationandimplicationofadiposederivedstemcellsincraniofacialboneregenerationandrepair AT liwenli optimizationandimplicationofadiposederivedstemcellsincraniofacialboneregenerationandrepair AT yipingchen optimizationandimplicationofadiposederivedstemcellsincraniofacialboneregenerationandrepair |