Progressive gut microbiota shifts and functional alterations across aging stages and frailty in mice

Progressive gut microbiota shifts and functional alterations across aging stages and frailty in mice

Summary: The gut microbiota modulates aging through metabolic and immune interactions. To characterize microbial changes during aging, we profiled gut microbiota across four stages in male C57BL/6J mice: young-adult, middle-aged, senescent, and frailty. Using 16S rRNA sequencing and targeted metabol...

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Bibliographic Details
Main Authors: Xinwei Jiao, Hongyu Li, Ting Wang, Hongchen Fu, Shiwu Wang, Hong Liu, Lei Wang, Xiuyun Li, Aijun Deng, Zhijie Li
Format: Article
Language:English
Published: Elsevier 2025-07-01
Series:iScience
Subjects:
Microbiology
Microbiome
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004225012465
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