COMPARATIVE ASSESSMENT OF AERODYNAMIC PROPERTIES OF SALBUTAMOL PRESSURIZED METERED DOSE INHALERS
The aerodynamic properties of the developed generic product Salbutamol metered dose inhaler 100 μg/dose and Salbutamol-Teva metered dose inhaler 100 μg/dose using apparatuses A, C, D and E in accordance with the general article 2.9.18 of the European Pharmacopoeia have been studied. In vitro equival...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | Russian |
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LLC Center of Pharmaceutical Analytics (LLC «CPHA»)
2019-01-01
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| Series: | Разработка и регистрация лекарственных средств |
| Subjects: | |
| Online Access: | https://www.pharmjournal.ru/jour/article/view/545 |
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| author | N. A. Lyapunov E. P. Bezuglaya V. A. Bovtenko Yu. M. Stolper |
| author_facet | N. A. Lyapunov E. P. Bezuglaya V. A. Bovtenko Yu. M. Stolper |
| author_sort | N. A. Lyapunov |
| collection | DOAJ |
| description | The aerodynamic properties of the developed generic product Salbutamol metered dose inhaler 100 μg/dose and Salbutamol-Teva metered dose inhaler 100 μg/dose using apparatuses A, C, D and E in accordance with the general article 2.9.18 of the European Pharmacopoeia have been studied. In vitro equivalence of the generic product and the comparator with regard to such aerodynamic characteristics as the fine particle dose, the particle size distribution, the relative amount of salbutamol passed through the apparatus stages, the mass median aerodynamic diameter (MMAD), and the geometric standard deviation (GSD) has been shown. It is shown that the device A is useful for testing of the respirable fraction, and the apparatuses D and E are suitable for the assessment of the particle size distribution, MMAD and GSD. |
| format | Article |
| id | doaj-art-8b2dfed2da0e40a1b635ba1b7c6eec3b |
| institution | DOAJ |
| issn | 2305-2066 2658-5049 |
| language | Russian |
| publishDate | 2019-01-01 |
| publisher | LLC Center of Pharmaceutical Analytics (LLC «CPHA») |
| record_format | Article |
| series | Разработка и регистрация лекарственных средств |
| spelling | doaj-art-8b2dfed2da0e40a1b635ba1b7c6eec3b2025-08-20T02:54:19ZrusLLC Center of Pharmaceutical Analytics (LLC «CPHA»)Разработка и регистрация лекарственных средств2305-20662658-50492019-01-01015461545COMPARATIVE ASSESSMENT OF AERODYNAMIC PROPERTIES OF SALBUTAMOL PRESSURIZED METERED DOSE INHALERSN. A. Lyapunov0E. P. Bezuglaya1V. A. Bovtenko2Yu. M. Stolper3Institute for Single Crystals of the National Academy of Sciences of UkraineInstitute for Single Crystals of the National Academy of Sciences of UkraineInstitute for Single Crystals of the National Academy of Sciences of UkraineInstitute for Single Crystals of the National Academy of Sciences of UkraineThe aerodynamic properties of the developed generic product Salbutamol metered dose inhaler 100 μg/dose and Salbutamol-Teva metered dose inhaler 100 μg/dose using apparatuses A, C, D and E in accordance with the general article 2.9.18 of the European Pharmacopoeia have been studied. In vitro equivalence of the generic product and the comparator with regard to such aerodynamic characteristics as the fine particle dose, the particle size distribution, the relative amount of salbutamol passed through the apparatus stages, the mass median aerodynamic diameter (MMAD), and the geometric standard deviation (GSD) has been shown. It is shown that the device A is useful for testing of the respirable fraction, and the apparatuses D and E are suitable for the assessment of the particle size distribution, MMAD and GSD.https://www.pharmjournal.ru/jour/article/view/545salbutamolpressurized metered dose inhalerimpingerimpactorfine particle doseparticle size distribution |
| spellingShingle | N. A. Lyapunov E. P. Bezuglaya V. A. Bovtenko Yu. M. Stolper COMPARATIVE ASSESSMENT OF AERODYNAMIC PROPERTIES OF SALBUTAMOL PRESSURIZED METERED DOSE INHALERS Разработка и регистрация лекарственных средств salbutamol pressurized metered dose inhaler impinger impactor fine particle dose particle size distribution |
| title | COMPARATIVE ASSESSMENT OF AERODYNAMIC PROPERTIES OF SALBUTAMOL PRESSURIZED METERED DOSE INHALERS |
| title_full | COMPARATIVE ASSESSMENT OF AERODYNAMIC PROPERTIES OF SALBUTAMOL PRESSURIZED METERED DOSE INHALERS |
| title_fullStr | COMPARATIVE ASSESSMENT OF AERODYNAMIC PROPERTIES OF SALBUTAMOL PRESSURIZED METERED DOSE INHALERS |
| title_full_unstemmed | COMPARATIVE ASSESSMENT OF AERODYNAMIC PROPERTIES OF SALBUTAMOL PRESSURIZED METERED DOSE INHALERS |
| title_short | COMPARATIVE ASSESSMENT OF AERODYNAMIC PROPERTIES OF SALBUTAMOL PRESSURIZED METERED DOSE INHALERS |
| title_sort | comparative assessment of aerodynamic properties of salbutamol pressurized metered dose inhalers |
| topic | salbutamol pressurized metered dose inhaler impinger impactor fine particle dose particle size distribution |
| url | https://www.pharmjournal.ru/jour/article/view/545 |
| work_keys_str_mv | AT nalyapunov comparativeassessmentofaerodynamicpropertiesofsalbutamolpressurizedmetereddoseinhalers AT epbezuglaya comparativeassessmentofaerodynamicpropertiesofsalbutamolpressurizedmetereddoseinhalers AT vabovtenko comparativeassessmentofaerodynamicpropertiesofsalbutamolpressurizedmetereddoseinhalers AT yumstolper comparativeassessmentofaerodynamicpropertiesofsalbutamolpressurizedmetereddoseinhalers |