Unilateral Cervical Polyneuropathies following Concurrent Bortezomib, Cetuximab, and Radiotherapy for Head and Neck Cancer
We report a constellation of cervical polyneuropathies in a patient treated with concurrent bortezomib, cetuximab, and cisplatin alongside intensity modulated radiotherapy for carcinoma of the tonsil with neck metastasis. The described deficits include brachial plexopathy, cervical sensory neuropath...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Case Reports in Otolaryngology |
| Online Access: | http://dx.doi.org/10.1155/2016/2313714 |
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| author | Alhasan Elghouche Tom Shokri Yewen Qin Susannah Wargo Deborah Citrin Carter Van Waes |
| author_facet | Alhasan Elghouche Tom Shokri Yewen Qin Susannah Wargo Deborah Citrin Carter Van Waes |
| author_sort | Alhasan Elghouche |
| collection | DOAJ |
| description | We report a constellation of cervical polyneuropathies in a patient treated with concurrent bortezomib, cetuximab, and cisplatin alongside intensity modulated radiotherapy for carcinoma of the tonsil with neck metastasis. The described deficits include brachial plexopathy, cervical sensory neuropathy, and oculosympathetic, recurrent laryngeal, and phrenic nerve palsies within the ipsilateral radiation field. Radiation neuropathy involving the brachial plexus is typically associated with treatment of breast or lung cancer; however, increased awareness of this entity in the context of investigational agents with potential neuropathic effects in head and neck cancer has recently emerged. With this report, we highlight radiation neuropathy in the setting of investigational therapy for head and neck cancer, particularly since these sequelae may present years after therapy and entail significant and often irreversible morbidity. |
| format | Article |
| id | doaj-art-8b2d4bf9710543dfb5e65a9f13b522de |
| institution | Kabale University |
| issn | 2090-6765 2090-6773 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Otolaryngology |
| spelling | doaj-art-8b2d4bf9710543dfb5e65a9f13b522de2025-08-20T03:37:34ZengWileyCase Reports in Otolaryngology2090-67652090-67732016-01-01201610.1155/2016/23137142313714Unilateral Cervical Polyneuropathies following Concurrent Bortezomib, Cetuximab, and Radiotherapy for Head and Neck CancerAlhasan Elghouche0Tom Shokri1Yewen Qin2Susannah Wargo3Deborah Citrin4Carter Van Waes5Indiana University School of Medicine, 1120 W. Michigan Street, Suite 200, Indianapolis, IN 46202, USADivision of Otolaryngology, Penn State Milton S. Hershey Medical Center, 100 Campus Drive, Suite 400, Hershey, PA 17033, USAKing’s College London School of Medicine, Strand, London WC2R 2LS, UKHead and Neck Surgery Branch, National Institute on Deafness and Other Communication Disorders, 9000 Rockville Pike, Bethesda, MD 20892, USARadiation Oncology Branch, Center for Cancer Research, National Cancer Institute, 9000 Rockville Pike, Bethesda, MD 20892, USAHead and Neck Surgery Branch, National Institute on Deafness and Other Communication Disorders, 9000 Rockville Pike, Bethesda, MD 20892, USAWe report a constellation of cervical polyneuropathies in a patient treated with concurrent bortezomib, cetuximab, and cisplatin alongside intensity modulated radiotherapy for carcinoma of the tonsil with neck metastasis. The described deficits include brachial plexopathy, cervical sensory neuropathy, and oculosympathetic, recurrent laryngeal, and phrenic nerve palsies within the ipsilateral radiation field. Radiation neuropathy involving the brachial plexus is typically associated with treatment of breast or lung cancer; however, increased awareness of this entity in the context of investigational agents with potential neuropathic effects in head and neck cancer has recently emerged. With this report, we highlight radiation neuropathy in the setting of investigational therapy for head and neck cancer, particularly since these sequelae may present years after therapy and entail significant and often irreversible morbidity.http://dx.doi.org/10.1155/2016/2313714 |
| spellingShingle | Alhasan Elghouche Tom Shokri Yewen Qin Susannah Wargo Deborah Citrin Carter Van Waes Unilateral Cervical Polyneuropathies following Concurrent Bortezomib, Cetuximab, and Radiotherapy for Head and Neck Cancer Case Reports in Otolaryngology |
| title | Unilateral Cervical Polyneuropathies following Concurrent Bortezomib, Cetuximab, and Radiotherapy for Head and Neck Cancer |
| title_full | Unilateral Cervical Polyneuropathies following Concurrent Bortezomib, Cetuximab, and Radiotherapy for Head and Neck Cancer |
| title_fullStr | Unilateral Cervical Polyneuropathies following Concurrent Bortezomib, Cetuximab, and Radiotherapy for Head and Neck Cancer |
| title_full_unstemmed | Unilateral Cervical Polyneuropathies following Concurrent Bortezomib, Cetuximab, and Radiotherapy for Head and Neck Cancer |
| title_short | Unilateral Cervical Polyneuropathies following Concurrent Bortezomib, Cetuximab, and Radiotherapy for Head and Neck Cancer |
| title_sort | unilateral cervical polyneuropathies following concurrent bortezomib cetuximab and radiotherapy for head and neck cancer |
| url | http://dx.doi.org/10.1155/2016/2313714 |
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