Dissecting PTPN7‐driven aggressiveness in IDH‐wildtype astrocytomas: multi‐omics, clinical validation, and spatial transcriptomics for prognostic insights

Dissecting PTPN7‐driven aggressiveness in IDH‐wildtype astrocytomas: multi‐omics, clinical validation, and spatial transcriptomics for prognostic insights

Abstract Background Gliomas, particularly IDH‐wildtype astrocytomas, remain highly aggressive and resistant to current therapies. Despite advances in molecular classification, effective therapeutic targets are still limited. Consequently, identifying new targets is essential to improve patient survi...

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Bibliographic Details
Main Authors: Tung Liu, Yu-Chieh Lin, Pei-Chi Chang, Dueng-Yuan Hueng, Yao-Feng Li
Format: Article
Language:English
Published: Springer 2025-05-01
Series:Discover Oncology
Subjects:
PTPN7
Glioma
Glioblastoma
TCGA
CGGA
Ivy dataset
Online Access:https://doi.org/10.1007/s12672-025-02662-5
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