Evaluation of the effect of subclinical hypothyroidism on retinal blood flow. OCT angiography study
Purpose: To evaluate retinal blood flow and retinal nerve fiber layer (RNFL) thickness in untreated subclinical hypothyroid patients by optical coherence tomography angiography (OCT-A). Methods: Forty-four eyes of 44 patients in the subclinical hypothyroidism group (SCHG) and 42 eyes of 42 healthy s...
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Elsevier
2025-04-01
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| Series: | Photodiagnosis and Photodynamic Therapy |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1572100025000602 |
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| author | Irfan Botan Gunes Eda Demir Onal |
| author_facet | Irfan Botan Gunes Eda Demir Onal |
| author_sort | Irfan Botan Gunes |
| collection | DOAJ |
| description | Purpose: To evaluate retinal blood flow and retinal nerve fiber layer (RNFL) thickness in untreated subclinical hypothyroid patients by optical coherence tomography angiography (OCT-A). Methods: Forty-four eyes of 44 patients in the subclinical hypothyroidism group (SCHG) and 42 eyes of 42 healthy subjects in the control group (CG) were included in the study. Macular superficial retinal blood flow (SRBF), peripapillary RNFL thickness and optic nerve head cup to disk ratio (C/D) were measured and recorded by OCT angiography and compared between the patient and control groups. Correlation analysis between disease duration and SRBF and RNFL thickness was also performed. Results: Mean SRBF was 37.23 ± 2.11 in the SCH group and 38.45±1.20 in the control group. Mean SRBF was significantly lower in the SCH group (p=0.003). Mean Peripapillary RNFL thickness was 98.18±7.77 in the SCH group and 100.07 ± 7.71 in control group. Peripapillary RNFL thickness was not significantly different between groups (p=0.290). There was no significant difference in mean C/D between the groups (p=0.708). Correlation analysis showed a moderate negative correlation between duration of disease diagnosis and SRBF in the SCH group (p<0.001, r=-0.564). There was also a weak to moderate negative correlation between disease duration and RNFL thickness in SCH group (p=0.002, r=-0.489). Conclusions: A reduction in SRBF was observed in patients with subclinical hypothyroidism. Additionally, a negative correlation was identified between disease duration and RNFL thickness. Patients with subclinical hypothyroidism should be monitored for potential retinal vascular disease and the development of normotensive glaucoma. |
| format | Article |
| id | doaj-art-8b215907a2224f5f933a7ec03206fa4b |
| institution | DOAJ |
| issn | 1572-1000 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Elsevier |
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| series | Photodiagnosis and Photodynamic Therapy |
| spelling | doaj-art-8b215907a2224f5f933a7ec03206fa4b2025-08-20T03:16:26ZengElsevierPhotodiagnosis and Photodynamic Therapy1572-10002025-04-015210453010.1016/j.pdpdt.2025.104530Evaluation of the effect of subclinical hypothyroidism on retinal blood flow. OCT angiography studyIrfan Botan Gunes0Eda Demir Onal1Department of Ophthalmology, Medicalpark Kocaeli Hospital, Kocaeli Health and Technology University, Kocaeli, Turkey; Corresponding author at: Department of Ophthalmology, Medicalpark Kocaeli Hospital, Kocaeli Health and Technology University, Kocaeli, Turkey.Department of Endocrinology, Medicalpark Kocaeli Hospital, Kocaeli, TurkeyPurpose: To evaluate retinal blood flow and retinal nerve fiber layer (RNFL) thickness in untreated subclinical hypothyroid patients by optical coherence tomography angiography (OCT-A). Methods: Forty-four eyes of 44 patients in the subclinical hypothyroidism group (SCHG) and 42 eyes of 42 healthy subjects in the control group (CG) were included in the study. Macular superficial retinal blood flow (SRBF), peripapillary RNFL thickness and optic nerve head cup to disk ratio (C/D) were measured and recorded by OCT angiography and compared between the patient and control groups. Correlation analysis between disease duration and SRBF and RNFL thickness was also performed. Results: Mean SRBF was 37.23 ± 2.11 in the SCH group and 38.45±1.20 in the control group. Mean SRBF was significantly lower in the SCH group (p=0.003). Mean Peripapillary RNFL thickness was 98.18±7.77 in the SCH group and 100.07 ± 7.71 in control group. Peripapillary RNFL thickness was not significantly different between groups (p=0.290). There was no significant difference in mean C/D between the groups (p=0.708). Correlation analysis showed a moderate negative correlation between duration of disease diagnosis and SRBF in the SCH group (p<0.001, r=-0.564). There was also a weak to moderate negative correlation between disease duration and RNFL thickness in SCH group (p=0.002, r=-0.489). Conclusions: A reduction in SRBF was observed in patients with subclinical hypothyroidism. Additionally, a negative correlation was identified between disease duration and RNFL thickness. Patients with subclinical hypothyroidism should be monitored for potential retinal vascular disease and the development of normotensive glaucoma.http://www.sciencedirect.com/science/article/pii/S1572100025000602HypothyroidismTomographyOptical coherenceNerve fibersRetinaBlood circulation |
| spellingShingle | Irfan Botan Gunes Eda Demir Onal Evaluation of the effect of subclinical hypothyroidism on retinal blood flow. OCT angiography study Photodiagnosis and Photodynamic Therapy Hypothyroidism Tomography Optical coherence Nerve fibers Retina Blood circulation |
| title | Evaluation of the effect of subclinical hypothyroidism on retinal blood flow. OCT angiography study |
| title_full | Evaluation of the effect of subclinical hypothyroidism on retinal blood flow. OCT angiography study |
| title_fullStr | Evaluation of the effect of subclinical hypothyroidism on retinal blood flow. OCT angiography study |
| title_full_unstemmed | Evaluation of the effect of subclinical hypothyroidism on retinal blood flow. OCT angiography study |
| title_short | Evaluation of the effect of subclinical hypothyroidism on retinal blood flow. OCT angiography study |
| title_sort | evaluation of the effect of subclinical hypothyroidism on retinal blood flow oct angiography study |
| topic | Hypothyroidism Tomography Optical coherence Nerve fibers Retina Blood circulation |
| url | http://www.sciencedirect.com/science/article/pii/S1572100025000602 |
| work_keys_str_mv | AT irfanbotangunes evaluationoftheeffectofsubclinicalhypothyroidismonretinalbloodflowoctangiographystudy AT edademironal evaluationoftheeffectofsubclinicalhypothyroidismonretinalbloodflowoctangiographystudy |