Novel thiophene derivatives with sulfonamide, isoxazole, benzothiazole, quinoline and anthracene moieties as potential anticancer agents
A novel series of thiophenes having biologically active sulfonamide 2-11, 3-methylisoxazole 12, 4-methoxybenzo[d] thiazole 13, quinoline 14, 15, benzoylphenylamino 16, and anthracene-9,10-dione 17 moieties were prepared. Structures of the newly synthesized compounds were established by elemental ana...
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| Format: | Article |
| Language: | English |
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Sciendo
2014-12-01
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| Series: | Acta Pharmaceutica |
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| Online Access: | https://doi.org/10.2478/acph-2014-0035 |
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| author | Ghorab Mostafa M. Bashandy Mahmoud S. Alsaid Mansour S. |
| author_facet | Ghorab Mostafa M. Bashandy Mahmoud S. Alsaid Mansour S. |
| author_sort | Ghorab Mostafa M. |
| collection | DOAJ |
| description | A novel series of thiophenes having biologically active sulfonamide 2-11, 3-methylisoxazole 12, 4-methoxybenzo[d] thiazole 13, quinoline 14, 15, benzoylphenylamino 16, and anthracene-9,10-dione 17 moieties were prepared. Structures of the newly synthesized compounds were established by elemental analysis and spectral data. All newly synthesized compounds were evaluated for their in vitro anticancer activity against human breast cancer cell line (MCF7). Most of the screened compounds showed cytotoxic activities compared to doxorubicin as a positive control. Compounds 6, 7, 9 and 13 (IC50 values 10.25, 9.70, 9.55 and 9.39 μmol L-1) revealed higher cytotoxic activities than that of doxorubicin (IC50 = 32.00 μmol L-1). Also, compounds 5, 8 and 10 were found nearly as active as doxorubicin (IC50 28.85, 23.48 and 27.51 μmol L-1). |
| format | Article |
| id | doaj-art-8b1b124ad7ed4d8c8b7db236f80dbe30 |
| institution | Kabale University |
| issn | 1846-9558 |
| language | English |
| publishDate | 2014-12-01 |
| publisher | Sciendo |
| record_format | Article |
| series | Acta Pharmaceutica |
| spelling | doaj-art-8b1b124ad7ed4d8c8b7db236f80dbe302025-02-02T17:46:43ZengSciendoActa Pharmaceutica1846-95582014-12-0164441943110.2478/acph-2014-0035acph-2014-0035Novel thiophene derivatives with sulfonamide, isoxazole, benzothiazole, quinoline and anthracene moieties as potential anticancer agentsGhorab Mostafa M.0Bashandy Mahmoud S.1Alsaid Mansour S.2Department of Pharmacognosy College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Kingdom of Saudi ArabiaDepartment of Chemistry, Faculty of Science (Boy’s), Al-Azhar University Nasr City, Cairo, EgyptDepartment of Pharmacognosy College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Kingdom of Saudi ArabiaA novel series of thiophenes having biologically active sulfonamide 2-11, 3-methylisoxazole 12, 4-methoxybenzo[d] thiazole 13, quinoline 14, 15, benzoylphenylamino 16, and anthracene-9,10-dione 17 moieties were prepared. Structures of the newly synthesized compounds were established by elemental analysis and spectral data. All newly synthesized compounds were evaluated for their in vitro anticancer activity against human breast cancer cell line (MCF7). Most of the screened compounds showed cytotoxic activities compared to doxorubicin as a positive control. Compounds 6, 7, 9 and 13 (IC50 values 10.25, 9.70, 9.55 and 9.39 μmol L-1) revealed higher cytotoxic activities than that of doxorubicin (IC50 = 32.00 μmol L-1). Also, compounds 5, 8 and 10 were found nearly as active as doxorubicin (IC50 28.85, 23.48 and 27.51 μmol L-1).https://doi.org/10.2478/acph-2014-0035thiophenessulfonamidesisoxazolebenzothiazolequinolineanthraceneanticancer activity |
| spellingShingle | Ghorab Mostafa M. Bashandy Mahmoud S. Alsaid Mansour S. Novel thiophene derivatives with sulfonamide, isoxazole, benzothiazole, quinoline and anthracene moieties as potential anticancer agents Acta Pharmaceutica thiophenes sulfonamides isoxazole benzothiazole quinoline anthracene anticancer activity |
| title | Novel thiophene derivatives with sulfonamide, isoxazole, benzothiazole, quinoline and anthracene moieties as potential anticancer agents |
| title_full | Novel thiophene derivatives with sulfonamide, isoxazole, benzothiazole, quinoline and anthracene moieties as potential anticancer agents |
| title_fullStr | Novel thiophene derivatives with sulfonamide, isoxazole, benzothiazole, quinoline and anthracene moieties as potential anticancer agents |
| title_full_unstemmed | Novel thiophene derivatives with sulfonamide, isoxazole, benzothiazole, quinoline and anthracene moieties as potential anticancer agents |
| title_short | Novel thiophene derivatives with sulfonamide, isoxazole, benzothiazole, quinoline and anthracene moieties as potential anticancer agents |
| title_sort | novel thiophene derivatives with sulfonamide isoxazole benzothiazole quinoline and anthracene moieties as potential anticancer agents |
| topic | thiophenes sulfonamides isoxazole benzothiazole quinoline anthracene anticancer activity |
| url | https://doi.org/10.2478/acph-2014-0035 |
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