Bile Acids and Their Value for Central Nervous System
Aim. A review to highlight the bile acids importance as steroid mediators of nervous system activity and show the nervous system involvement in cholesterol metabolism and bile acids production.Key points. Presence of bile acid membrane and nuclear receptors and their activation role in mediating man...
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| Format: | Article |
| Language: | Russian |
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Gastro LLC
2022-01-01
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| Series: | Российский журнал гастроэнтерологии, гепатологии, колопроктологии |
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| Online Access: | https://www.gastro-j.ru/jour/article/view/645 |
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| _version_ | 1823860057212715008 |
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| author | Yu. O. Shulpekova P. E. Tkachenko E. N. Shirokova I. V. Damulin |
| author_facet | Yu. O. Shulpekova P. E. Tkachenko E. N. Shirokova I. V. Damulin |
| author_sort | Yu. O. Shulpekova |
| collection | DOAJ |
| description | Aim. A review to highlight the bile acids importance as steroid mediators of nervous system activity and show the nervous system involvement in cholesterol metabolism and bile acids production.Key points. Presence of bile acid membrane and nuclear receptors and their activation role in mediating manifold metabolic processes have been established in various organs and tissues. Bile acid transporters are discovered in CNS. The animal brain under physiological conditions was found to contain about 20 bile acid types of likely innate origin suggested by their high contents; the bile acids spectrum in CNS differs significantly from blood plasma. Clinical and experimental works are conclusive about the CNS bile acids influence on mitochondrial membrane, their antioxidative role and, probably, steroid-mediator involvement in indirect regulation of memory, attention, motor functions and appetite.Conclusion. Bile acids act as pleiotropic signalling molecules affecting various tissues. The presence in CNS of various bile acid synthesis-related receptors and enzymes indicates their value in brain functioning and warrants research into their metabolism. |
| format | Article |
| id | doaj-art-8b19cdab173a4a0786e096d8d9114060 |
| institution | Kabale University |
| issn | 1382-4376 2658-6673 |
| language | Russian |
| publishDate | 2022-01-01 |
| publisher | Gastro LLC |
| record_format | Article |
| series | Российский журнал гастроэнтерологии, гепатологии, колопроктологии |
| spelling | doaj-art-8b19cdab173a4a0786e096d8d91140602025-02-10T16:14:37ZrusGastro LLCРоссийский журнал гастроэнтерологии, гепатологии, колопроктологии1382-43762658-66732022-01-0131571510.22416/1382-4376-2021-31-5-7-15443Bile Acids and Their Value for Central Nervous SystemYu. O. Shulpekova0P. E. Tkachenko1E. N. Shirokova2I. V. Damulin3Sechenov First Moscow State Medical University (Sechenov University)Sechenov First Moscow State Medical University (Sechenov University)Sechenov First Moscow State Medical University (Sechenov University)Moscow Research Institute of Psychiatry — Branch of Serbsky Federal Medical Research Centre of Psychiatry and Narcology, Ministry of Health of the Russian FederationAim. A review to highlight the bile acids importance as steroid mediators of nervous system activity and show the nervous system involvement in cholesterol metabolism and bile acids production.Key points. Presence of bile acid membrane and nuclear receptors and their activation role in mediating manifold metabolic processes have been established in various organs and tissues. Bile acid transporters are discovered in CNS. The animal brain under physiological conditions was found to contain about 20 bile acid types of likely innate origin suggested by their high contents; the bile acids spectrum in CNS differs significantly from blood plasma. Clinical and experimental works are conclusive about the CNS bile acids influence on mitochondrial membrane, their antioxidative role and, probably, steroid-mediator involvement in indirect regulation of memory, attention, motor functions and appetite.Conclusion. Bile acids act as pleiotropic signalling molecules affecting various tissues. The presence in CNS of various bile acid synthesis-related receptors and enzymes indicates their value in brain functioning and warrants research into their metabolism.https://www.gastro-j.ru/jour/article/view/645bile acidsfarnesoid x receptormitochondria |
| spellingShingle | Yu. O. Shulpekova P. E. Tkachenko E. N. Shirokova I. V. Damulin Bile Acids and Their Value for Central Nervous System Российский журнал гастроэнтерологии, гепатологии, колопроктологии bile acids farnesoid x receptor mitochondria |
| title | Bile Acids and Their Value for Central Nervous System |
| title_full | Bile Acids and Their Value for Central Nervous System |
| title_fullStr | Bile Acids and Their Value for Central Nervous System |
| title_full_unstemmed | Bile Acids and Their Value for Central Nervous System |
| title_short | Bile Acids and Their Value for Central Nervous System |
| title_sort | bile acids and their value for central nervous system |
| topic | bile acids farnesoid x receptor mitochondria |
| url | https://www.gastro-j.ru/jour/article/view/645 |
| work_keys_str_mv | AT yuoshulpekova bileacidsandtheirvalueforcentralnervoussystem AT petkachenko bileacidsandtheirvalueforcentralnervoussystem AT enshirokova bileacidsandtheirvalueforcentralnervoussystem AT ivdamulin bileacidsandtheirvalueforcentralnervoussystem |