Role of astrocytes in the pathogenesis of perinatal brain injury

Role of astrocytes in the pathogenesis of perinatal brain injury

Abstract Astrocytes, the most abundant glial cells in the central nervous system (CNS), play critical roles in blood–brain barrier (BBB) maintenance, synaptogenesis, neurotransmission, and metabolic regulation. In response to perinatal brain injury, astrocytes release inflammatory mediators that dri...

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Bibliographic Details
Main Authors: Ling Li, Xuewei Cui, Baoli Zhu, Lele Zhou, Yaya Guo, Tianjing Liu, Yongyan Shi
Format: Article
Language:English
Published: BMC 2025-08-01
Series:Molecular Medicine
Subjects:
Astrocytes
Perinatal brain injury
JAK/STAT
Notch
NF-κB
Glutamate transporter
Online Access:https://doi.org/10.1186/s10020-025-01328-w
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