Limited research investigating the value of MRI in predicting future cognitive morbidity in survivors of paediatric brain tumours: A systematic-review and call to action for clinical neuroimaging researchers.

Survivors of pediatric brain tumours are at a high risk of cognitive morbidity. Reliable individual-level predictions regarding the likelihood, degree, and affected domains of cognitive impairment would be clinically beneficial. While established risk factors exist, quantitative MRI analysis may enh...

Full description

Saved in:
Bibliographic Details
Main Authors: Daniel J Griffiths-King, Christopher Delivett, Andrew Peet, Jane Waite, Jan Novak
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2025-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0314721
Tags: Add Tag
No Tags, Be the first to tag this record!
_version_ 1825206801608474624
author Daniel J Griffiths-King
Christopher Delivett
Andrew Peet
Jane Waite
Jan Novak
author_facet Daniel J Griffiths-King
Christopher Delivett
Andrew Peet
Jane Waite
Jan Novak
author_sort Daniel J Griffiths-King
collection DOAJ
description Survivors of pediatric brain tumours are at a high risk of cognitive morbidity. Reliable individual-level predictions regarding the likelihood, degree, and affected domains of cognitive impairment would be clinically beneficial. While established risk factors exist, quantitative MRI analysis may enhance predictive value, above and beyond current clinical risk models. This systematic review addresses the question: "Do MRI markers predict future cognitive functioning in pediatric brain tumour survivors?" We conducted a comprehensive search for studies published up to March 2024 that assessed MRI variables as predictors of later neuropsychological outcomes in pediatric brain tumour patients. Only studies that acquired MRI scans at an earlier timepoint to predict subsequent cognitive test performance were included. Surprisingly, few studies met these criteria, with identified research focusing primarily on MRI measures of cerebellar and white matter damage as features in predicting cognitive outcomes. Ultimately, this review reveals a limited literature, characterized by small sample sizes and poor-quality studies, placing findings at high risk of bias. Consequently, the quality and conclusions drawn from the existing research are constrained, especially in the context of prediction studies. Given the significant implications for this clinical population, this review highlights the urgent need for further investigation and a 'call to action' for medical imaging researchers in pediatric neuro-oncology.
format Article
id doaj-art-8b16277c261b4b04886854169cecd36a
institution Kabale University
issn 1932-6203
language English
publishDate 2025-01-01
publisher Public Library of Science (PLoS)
record_format Article
series PLoS ONE
spelling doaj-art-8b16277c261b4b04886854169cecd36a2025-02-07T05:30:49ZengPublic Library of Science (PLoS)PLoS ONE1932-62032025-01-01201e031472110.1371/journal.pone.0314721Limited research investigating the value of MRI in predicting future cognitive morbidity in survivors of paediatric brain tumours: A systematic-review and call to action for clinical neuroimaging researchers.Daniel J Griffiths-KingChristopher DelivettAndrew PeetJane WaiteJan NovakSurvivors of pediatric brain tumours are at a high risk of cognitive morbidity. Reliable individual-level predictions regarding the likelihood, degree, and affected domains of cognitive impairment would be clinically beneficial. While established risk factors exist, quantitative MRI analysis may enhance predictive value, above and beyond current clinical risk models. This systematic review addresses the question: "Do MRI markers predict future cognitive functioning in pediatric brain tumour survivors?" We conducted a comprehensive search for studies published up to March 2024 that assessed MRI variables as predictors of later neuropsychological outcomes in pediatric brain tumour patients. Only studies that acquired MRI scans at an earlier timepoint to predict subsequent cognitive test performance were included. Surprisingly, few studies met these criteria, with identified research focusing primarily on MRI measures of cerebellar and white matter damage as features in predicting cognitive outcomes. Ultimately, this review reveals a limited literature, characterized by small sample sizes and poor-quality studies, placing findings at high risk of bias. Consequently, the quality and conclusions drawn from the existing research are constrained, especially in the context of prediction studies. Given the significant implications for this clinical population, this review highlights the urgent need for further investigation and a 'call to action' for medical imaging researchers in pediatric neuro-oncology.https://doi.org/10.1371/journal.pone.0314721
spellingShingle Daniel J Griffiths-King
Christopher Delivett
Andrew Peet
Jane Waite
Jan Novak
Limited research investigating the value of MRI in predicting future cognitive morbidity in survivors of paediatric brain tumours: A systematic-review and call to action for clinical neuroimaging researchers.
PLoS ONE
title Limited research investigating the value of MRI in predicting future cognitive morbidity in survivors of paediatric brain tumours: A systematic-review and call to action for clinical neuroimaging researchers.
title_full Limited research investigating the value of MRI in predicting future cognitive morbidity in survivors of paediatric brain tumours: A systematic-review and call to action for clinical neuroimaging researchers.
title_fullStr Limited research investigating the value of MRI in predicting future cognitive morbidity in survivors of paediatric brain tumours: A systematic-review and call to action for clinical neuroimaging researchers.
title_full_unstemmed Limited research investigating the value of MRI in predicting future cognitive morbidity in survivors of paediatric brain tumours: A systematic-review and call to action for clinical neuroimaging researchers.
title_short Limited research investigating the value of MRI in predicting future cognitive morbidity in survivors of paediatric brain tumours: A systematic-review and call to action for clinical neuroimaging researchers.
title_sort limited research investigating the value of mri in predicting future cognitive morbidity in survivors of paediatric brain tumours a systematic review and call to action for clinical neuroimaging researchers
url https://doi.org/10.1371/journal.pone.0314721
work_keys_str_mv AT danieljgriffithsking limitedresearchinvestigatingthevalueofmriinpredictingfuturecognitivemorbidityinsurvivorsofpaediatricbraintumoursasystematicreviewandcalltoactionforclinicalneuroimagingresearchers
AT christopherdelivett limitedresearchinvestigatingthevalueofmriinpredictingfuturecognitivemorbidityinsurvivorsofpaediatricbraintumoursasystematicreviewandcalltoactionforclinicalneuroimagingresearchers
AT andrewpeet limitedresearchinvestigatingthevalueofmriinpredictingfuturecognitivemorbidityinsurvivorsofpaediatricbraintumoursasystematicreviewandcalltoactionforclinicalneuroimagingresearchers
AT janewaite limitedresearchinvestigatingthevalueofmriinpredictingfuturecognitivemorbidityinsurvivorsofpaediatricbraintumoursasystematicreviewandcalltoactionforclinicalneuroimagingresearchers
AT jannovak limitedresearchinvestigatingthevalueofmriinpredictingfuturecognitivemorbidityinsurvivorsofpaediatricbraintumoursasystematicreviewandcalltoactionforclinicalneuroimagingresearchers