mRNA‐Engineered CD5‐CAR‐γδTCD5‐ Cells for the Immunotherapy of T‐Cell Acute Lymphoblastic Leukemia

mRNA‐Engineered CD5‐CAR‐γδTCD5‐ Cells for the Immunotherapy of T‐Cell Acute Lymphoblastic Leukemia

Abstract Clinical trials of Chimeric Antigen Receptor T‐cell (CAR‐T) therapy have demonstrated remarkable success in treating both solid tumors and hematological malignancies. Nanobodies (Nbs) have emerged as promising antigen‐targeting domains for CARs, owing to their high specificity, robust stabi...

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Main Authors: Zhixiong Zhu, Hexian Li, Qizhong Lu, Zongliang Zhang, Jia Li, Zeng Wang, Nian Yang, Zhengyu Yu, Chen Yang, Yongdong Chen, Huaqing Lu, Wei Wang, Ting Niu, Chunlai Nie, Aiping Tong
Format: Article
Language:English
Published: Wiley 2024-09-01
Series:Advanced Science
Subjects:
CAR‐T
IVT‐mRNA
T‐ALL
γδT cells
Online Access:https://doi.org/10.1002/advs.202400024
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