Water-Solubilization of P(V) and Sb(V) Porphyrins and Their Photobiological Application
Porphyrins have been widely utilized as biochemical and biological functional chromophores which can operate under visible-light irradiation. Water-soluble porphyrins have been used as the drug for photodynamic therapy (PDT) and photodynamic inactivation (PDI). Although usual water-solubilization of...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | International Journal of Photoenergy |
| Online Access: | http://dx.doi.org/10.1155/2015/148964 |
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| author | Jin Matsumoto Tsutomu Shiragami Kazutaka Hirakawa Masahide Yasuda |
| author_facet | Jin Matsumoto Tsutomu Shiragami Kazutaka Hirakawa Masahide Yasuda |
| author_sort | Jin Matsumoto |
| collection | DOAJ |
| description | Porphyrins have been widely utilized as biochemical and biological functional chromophores which can operate under visible-light irradiation. Water-soluble porphyrins have been used as the drug for photodynamic therapy (PDT) and photodynamic inactivation (PDI). Although usual water-solubilization of porphyrins has been achieved by an introduction of an ionic group such as ammonium, pyridinium, sulfonate, phosphonium, or carboxyl to porphyrin ring, we proposed the preparation of water-soluble P and Sb porphyrins by modification of axial ligands. Alkyl (type A), ethylenedioxy (type E), pyridinium (type P), and glucosyl groups (type G) were introduced to axial ligands of Sb and P porphyrins to achieve water-solubilization of Sb porphyrin and P porphyrins. Here, we review their water-soluble P and Sb porphyrins from the standpoints of preparation, bioaffinity, and photosensitized inactivation. |
| format | Article |
| id | doaj-art-8b13b5ce81f6444481fa57960323aea1 |
| institution | Kabale University |
| issn | 1110-662X 1687-529X |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Photoenergy |
| spelling | doaj-art-8b13b5ce81f6444481fa57960323aea12025-08-20T03:37:35ZengWileyInternational Journal of Photoenergy1110-662X1687-529X2015-01-01201510.1155/2015/148964148964Water-Solubilization of P(V) and Sb(V) Porphyrins and Their Photobiological ApplicationJin Matsumoto0Tsutomu Shiragami1Kazutaka Hirakawa2Masahide Yasuda3Department of Applied Chemistry, Faculty of Engineering, University of Miyazaki, Gakuen-Kibanadai, Miyazaki 889-2192, JapanDepartment of Applied Chemistry, Faculty of Engineering, University of Miyazaki, Gakuen-Kibanadai, Miyazaki 889-2192, JapanDepartment of Applied Chemistry and Biochemical Engineering, Graduate School of Engineering, Shizuoka University, Johoku 3-5-1, Hamamatsu, Shizuoka 432-8561, JapanDepartment of Applied Chemistry, Faculty of Engineering, University of Miyazaki, Gakuen-Kibanadai, Miyazaki 889-2192, JapanPorphyrins have been widely utilized as biochemical and biological functional chromophores which can operate under visible-light irradiation. Water-soluble porphyrins have been used as the drug for photodynamic therapy (PDT) and photodynamic inactivation (PDI). Although usual water-solubilization of porphyrins has been achieved by an introduction of an ionic group such as ammonium, pyridinium, sulfonate, phosphonium, or carboxyl to porphyrin ring, we proposed the preparation of water-soluble P and Sb porphyrins by modification of axial ligands. Alkyl (type A), ethylenedioxy (type E), pyridinium (type P), and glucosyl groups (type G) were introduced to axial ligands of Sb and P porphyrins to achieve water-solubilization of Sb porphyrin and P porphyrins. Here, we review their water-soluble P and Sb porphyrins from the standpoints of preparation, bioaffinity, and photosensitized inactivation.http://dx.doi.org/10.1155/2015/148964 |
| spellingShingle | Jin Matsumoto Tsutomu Shiragami Kazutaka Hirakawa Masahide Yasuda Water-Solubilization of P(V) and Sb(V) Porphyrins and Their Photobiological Application International Journal of Photoenergy |
| title | Water-Solubilization of P(V) and Sb(V) Porphyrins and Their Photobiological Application |
| title_full | Water-Solubilization of P(V) and Sb(V) Porphyrins and Their Photobiological Application |
| title_fullStr | Water-Solubilization of P(V) and Sb(V) Porphyrins and Their Photobiological Application |
| title_full_unstemmed | Water-Solubilization of P(V) and Sb(V) Porphyrins and Their Photobiological Application |
| title_short | Water-Solubilization of P(V) and Sb(V) Porphyrins and Their Photobiological Application |
| title_sort | water solubilization of p v and sb v porphyrins and their photobiological application |
| url | http://dx.doi.org/10.1155/2015/148964 |
| work_keys_str_mv | AT jinmatsumoto watersolubilizationofpvandsbvporphyrinsandtheirphotobiologicalapplication AT tsutomushiragami watersolubilizationofpvandsbvporphyrinsandtheirphotobiologicalapplication AT kazutakahirakawa watersolubilizationofpvandsbvporphyrinsandtheirphotobiologicalapplication AT masahideyasuda watersolubilizationofpvandsbvporphyrinsandtheirphotobiologicalapplication |