FXR promotes clear cell renal cell carcinoma carcinogenesis via MMP-7-regulated EMT pathway

FXR promotes clear cell renal cell carcinoma carcinogenesis via MMP-7-regulated EMT pathway

Abstract Renal cell carcinoma (RCC) ranks as a prevalent malignant neoplasm, with clear cell renal cell carcinoma (ccRCC, also known as KIRC) accounting for approximately 75% of all RCC cases. The farnesoid X receptor (FXR, encoded by NR1H4), functioning as a nuclear receptor, plays a crucial role i...

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Bibliographic Details
Main Authors: Jiachen Liu, Shiyu Huang, Yanguang Hou, Shujie Fu, Lei Wang, Juncheng Hu, Cheng Liu, Xiuheng Liu
Format: Article
Language:English
Published: Nature Portfolio 2024-11-01
Series:Scientific Reports
Subjects:
FXR
MMP-7
EMT
ccRCC
Online Access:https://doi.org/10.1038/s41598-024-80368-4
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