Chemotherapy toxicity in elderly population ≥65 years: A tertiary care hospital experience from India
Context: Trials in the elderly have established that older individuals may benefit from chemotherapy to the same extent as younger individuals. Although the elderly patient is a prototype for cancer, very few clinical trials focus on the therapeutic decisions most directly facing older adults. Aims:...
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| Format: | Article |
| Language: | English |
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Thieme Medical and Scientific Publishers Pvt. Ltd.
2019-01-01
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| Series: | Indian Journal of Medical and Paediatric Oncology |
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| Online Access: | http://www.ijmpo.org/article.asp?issn=0971-5851;year=2019;volume=40;issue=4;spage=531;epage=535;aulast=Mittal |
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| author | Aditi Mittal Amit Agrawal Sandeep Batra Chandragouda Dodagoudar Suhail Qureshi |
| author_facet | Aditi Mittal Amit Agrawal Sandeep Batra Chandragouda Dodagoudar Suhail Qureshi |
| author_sort | Aditi Mittal |
| collection | DOAJ |
| description | Context: Trials in the elderly have established that older individuals may benefit from chemotherapy to the same extent as younger individuals. Although the elderly patient is a prototype for cancer, very few clinical trials focus on the therapeutic decisions most directly facing older adults. Aims: This study was undertaken to study the chemotherapy-induced severe toxicity among elderly. Settings and Design: This study was a prospective, observational cohort study. The study commenced in October 2014 after obtaining clearance from the hospital ethics and protocol committee. Subjects and Methods: A total of 100 patients were included in the study. All patients were of age ≥65 years, had malignancy, and were planned to start with chemotherapy. Development of Grade 3/4/5 nonhematologic (NH) or Grade 4/5 hematologic (H) toxicities was taken as the development of severe toxicity. Statistical Analysis Used: The quantitative variables were expressed as a mean ± standard deviation and compared using unpaired t-test. P < 0.05 was considered statistically significant. Results: Overall, 64 (64%) patients were able to complete their prescribed treatment. Forty-four patients (44%) of our study cohort experienced Grade 4 H or Grade 3/4 NH toxicity. The most common H Grade 4 toxicities were neutropenia (6%) and thrombocytopenia (5%). The most common NH toxicities were fatigue (18%), infection (10%), and cardiac abnormalities (4%). Conclusions: Less than 50% of elderly patients experience severe chemotherapy-related toxicity. First 30 days are most important for toxicity assessment as 45% of patients experienced toxicity in this time frame. |
| format | Article |
| id | doaj-art-8b12c789ce7c476eb3f9febb13ae1fed |
| institution | Kabale University |
| issn | 0971-5851 0975-2129 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Thieme Medical and Scientific Publishers Pvt. Ltd. |
| record_format | Article |
| series | Indian Journal of Medical and Paediatric Oncology |
| spelling | doaj-art-8b12c789ce7c476eb3f9febb13ae1fed2025-08-20T03:37:35ZengThieme Medical and Scientific Publishers Pvt. Ltd.Indian Journal of Medical and Paediatric Oncology0971-58510975-21292019-01-0140453153510.4103/ijmpo.ijmpo_62_18Chemotherapy toxicity in elderly population ≥65 years: A tertiary care hospital experience from IndiaAditi MittalAmit AgrawalSandeep BatraChandragouda DodagoudarSuhail QureshiContext: Trials in the elderly have established that older individuals may benefit from chemotherapy to the same extent as younger individuals. Although the elderly patient is a prototype for cancer, very few clinical trials focus on the therapeutic decisions most directly facing older adults. Aims: This study was undertaken to study the chemotherapy-induced severe toxicity among elderly. Settings and Design: This study was a prospective, observational cohort study. The study commenced in October 2014 after obtaining clearance from the hospital ethics and protocol committee. Subjects and Methods: A total of 100 patients were included in the study. All patients were of age ≥65 years, had malignancy, and were planned to start with chemotherapy. Development of Grade 3/4/5 nonhematologic (NH) or Grade 4/5 hematologic (H) toxicities was taken as the development of severe toxicity. Statistical Analysis Used: The quantitative variables were expressed as a mean ± standard deviation and compared using unpaired t-test. P < 0.05 was considered statistically significant. Results: Overall, 64 (64%) patients were able to complete their prescribed treatment. Forty-four patients (44%) of our study cohort experienced Grade 4 H or Grade 3/4 NH toxicity. The most common H Grade 4 toxicities were neutropenia (6%) and thrombocytopenia (5%). The most common NH toxicities were fatigue (18%), infection (10%), and cardiac abnormalities (4%). Conclusions: Less than 50% of elderly patients experience severe chemotherapy-related toxicity. First 30 days are most important for toxicity assessment as 45% of patients experienced toxicity in this time frame.http://www.ijmpo.org/article.asp?issn=0971-5851;year=2019;volume=40;issue=4;spage=531;epage=535;aulast=Mittalchemotherapyelderlyhematologicnonhematologictoxicity |
| spellingShingle | Aditi Mittal Amit Agrawal Sandeep Batra Chandragouda Dodagoudar Suhail Qureshi Chemotherapy toxicity in elderly population ≥65 years: A tertiary care hospital experience from India Indian Journal of Medical and Paediatric Oncology chemotherapy elderly hematologic nonhematologic toxicity |
| title | Chemotherapy toxicity in elderly population ≥65 years: A tertiary care hospital experience from India |
| title_full | Chemotherapy toxicity in elderly population ≥65 years: A tertiary care hospital experience from India |
| title_fullStr | Chemotherapy toxicity in elderly population ≥65 years: A tertiary care hospital experience from India |
| title_full_unstemmed | Chemotherapy toxicity in elderly population ≥65 years: A tertiary care hospital experience from India |
| title_short | Chemotherapy toxicity in elderly population ≥65 years: A tertiary care hospital experience from India |
| title_sort | chemotherapy toxicity in elderly population ≥65 years a tertiary care hospital experience from india |
| topic | chemotherapy elderly hematologic nonhematologic toxicity |
| url | http://www.ijmpo.org/article.asp?issn=0971-5851;year=2019;volume=40;issue=4;spage=531;epage=535;aulast=Mittal |
| work_keys_str_mv | AT aditimittal chemotherapytoxicityinelderlypopulation65yearsatertiarycarehospitalexperiencefromindia AT amitagrawal chemotherapytoxicityinelderlypopulation65yearsatertiarycarehospitalexperiencefromindia AT sandeepbatra chemotherapytoxicityinelderlypopulation65yearsatertiarycarehospitalexperiencefromindia AT chandragoudadodagoudar chemotherapytoxicityinelderlypopulation65yearsatertiarycarehospitalexperiencefromindia AT suhailqureshi chemotherapytoxicityinelderlypopulation65yearsatertiarycarehospitalexperiencefromindia |