N-glycans in lung tissue specimens: a prospective target for enhanced cancer diagnosis and prognosis

N-glycans in lung tissue specimens: a prospective target for enhanced cancer diagnosis and prognosis

Abstract Background It is well established that the cancerous transformation of cells is accompanied by profound alterations in glycosylation. In this study, we demonstrate the diagnostic potential of N-glycan profiling in tissue specimens from patients, primarily representing the two major types of...

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Bibliographic Details
Main Authors: Erika Lattova, Jana Skrickova, Jitka Hausnerova, Karolina Krystofova, Zbynek Zdrahal, Leos Kren, Mikulas Popovic
Format: Article
Language:English
Published: BMC 2025-08-01
Series:Journal of Translational Medicine
Subjects:
Lung cancer
Glycosylation
N-glycans
Branched glycans
Fucosylation
MALDI-MS
Online Access:https://doi.org/10.1186/s12967-025-06904-6
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