Beyond boundaries: extended temporal flexibility in synaptic tagging and capture
Abstract Synaptic tagging and capture (STC) is a mechanism that enables the formation of associative synaptic plasticity by marking activated synapses with “tags” to capture plasticity-related products (PRPs) essential for plasticity stabilization. Experimental evidence using long-term potentiation...
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| Format: | Article |
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Nature Portfolio
2025-04-01
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| Series: | Communications Biology |
| Online Access: | https://doi.org/10.1038/s42003-025-07998-w |
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| author | Yee Song Chong Sheila Ruixia Ang Sreedharan Sajikumar |
| author_facet | Yee Song Chong Sheila Ruixia Ang Sreedharan Sajikumar |
| author_sort | Yee Song Chong |
| collection | DOAJ |
| description | Abstract Synaptic tagging and capture (STC) is a mechanism that enables the formation of associative synaptic plasticity by marking activated synapses with “tags” to capture plasticity-related products (PRPs) essential for plasticity stabilization. Experimental evidence using long-term potentiation (LTP), a widely studied cellular correlate of memory, shows that the duration of synaptic tags varies, lasting up to 90 minutes in ex vivo hippocampal slices but shorter in in vivo conditions, likely due to higher metabolic activity. In this study, we investigate the time window for tag-PRP interactions in STC using a strong-before-weak paradigm, where protein synthesis-dependent late-LTP precedes protein synthesis-independent early-LTP at various intervals. Surprisingly, successful STC is observed even with a 9-hour interval in the strong-before-weak paradigm, suggesting a broader temporal flexibility for tag-PRP interactions than previously understood. This unexpected finding offers alternative explanations for associative memory formation by cataloguing memory events, allowing weaker memories to be strengthened when preceded by stronger ones. |
| format | Article |
| id | doaj-art-8b0dc192609e4a99b2bd87659540ed5c |
| institution | DOAJ |
| issn | 2399-3642 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Communications Biology |
| spelling | doaj-art-8b0dc192609e4a99b2bd87659540ed5c2025-08-20T03:07:44ZengNature PortfolioCommunications Biology2399-36422025-04-01811710.1038/s42003-025-07998-wBeyond boundaries: extended temporal flexibility in synaptic tagging and captureYee Song Chong0Sheila Ruixia Ang1Sreedharan Sajikumar2Department of Physiology, Yong Loo Lin School of Medicine, National University of SingaporeDepartment of Physiology, Yong Loo Lin School of Medicine, National University of SingaporeDepartment of Physiology, Yong Loo Lin School of Medicine, National University of SingaporeAbstract Synaptic tagging and capture (STC) is a mechanism that enables the formation of associative synaptic plasticity by marking activated synapses with “tags” to capture plasticity-related products (PRPs) essential for plasticity stabilization. Experimental evidence using long-term potentiation (LTP), a widely studied cellular correlate of memory, shows that the duration of synaptic tags varies, lasting up to 90 minutes in ex vivo hippocampal slices but shorter in in vivo conditions, likely due to higher metabolic activity. In this study, we investigate the time window for tag-PRP interactions in STC using a strong-before-weak paradigm, where protein synthesis-dependent late-LTP precedes protein synthesis-independent early-LTP at various intervals. Surprisingly, successful STC is observed even with a 9-hour interval in the strong-before-weak paradigm, suggesting a broader temporal flexibility for tag-PRP interactions than previously understood. This unexpected finding offers alternative explanations for associative memory formation by cataloguing memory events, allowing weaker memories to be strengthened when preceded by stronger ones.https://doi.org/10.1038/s42003-025-07998-w |
| spellingShingle | Yee Song Chong Sheila Ruixia Ang Sreedharan Sajikumar Beyond boundaries: extended temporal flexibility in synaptic tagging and capture Communications Biology |
| title | Beyond boundaries: extended temporal flexibility in synaptic tagging and capture |
| title_full | Beyond boundaries: extended temporal flexibility in synaptic tagging and capture |
| title_fullStr | Beyond boundaries: extended temporal flexibility in synaptic tagging and capture |
| title_full_unstemmed | Beyond boundaries: extended temporal flexibility in synaptic tagging and capture |
| title_short | Beyond boundaries: extended temporal flexibility in synaptic tagging and capture |
| title_sort | beyond boundaries extended temporal flexibility in synaptic tagging and capture |
| url | https://doi.org/10.1038/s42003-025-07998-w |
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