A novel scoring system for evaluating mortality risk of patients with sepsis during early hospitalization
Abstract Background Sepsis is a complex life-threatening condition. Early initiation of treatment is crucial in reducing mortality. Current scoring systems have a lack of reliability in the emergency department (ED) or during early hospitalization (EH). Thus, a quick, reliable, and objective scoring...
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BMC
2025-07-01
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| Series: | BMC Infectious Diseases |
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| Online Access: | https://doi.org/10.1186/s12879-025-10920-8 |
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| author | Ivan Aranza Miro Vuković Valentina Biloš Alen Juginović |
| author_facet | Ivan Aranza Miro Vuković Valentina Biloš Alen Juginović |
| author_sort | Ivan Aranza |
| collection | DOAJ |
| description | Abstract Background Sepsis is a complex life-threatening condition. Early initiation of treatment is crucial in reducing mortality. Current scoring systems have a lack of reliability in the emergency department (ED) or during early hospitalization (EH). Thus, a quick, reliable, and objective scoring system for assessing mortality risk during EH or ED could significantly reduce sepsis mortality. Methods Using the MIMIC-IV database, we identified 7546 patients hospitalized due to septicemia. We included 13 comorbidity groups and the first chronologically available values of 75 laboratory parameters from the ED or EH. To create and validate our scoring system for early prediction of in-hospital mortality (e-SEPSS), patients were assigned to model development (MD) (N = 1004) or model validation (MV) group (N = 6542), with the latter serving as internal validation of e-SEPSS. Each risk factor that contributed significantly to mortality was assigned one point. Groups with different numbers of points were compared according to mortality and hospitalization duration. Results Decreased chlorides, increased mean corpuscular hemoglobin, increased red blood cell distribution width, increased phosphates, decreased pH, increased partial thromboplastin time, and increased lactate dehydrogenase were included in e-SEPSS due to the highest reliability in predicting mortality. Patients received 1 point for each parameter, creating 8 mortality risk groups. A significant linear increase in mortality with each additional point was shown, ranging from 4.1% (0 points) to 100% (7 points) in the MD group. Similar trends were observed in the MV group. High power in discriminating patients with different mortality risks was shown (MD (ROC AUC = 0.718, CI 0.682–0.754), MV (ROC AUC = 0.798, CI 0.783–0.813)). Decreased survival time and shorter time-to-death with each additional point strengthened the validity of e-SEPSS (Mantel-Cox χ2(7) = 994.2, p-value < 0.001). Conclusion e-SEPSS provides a simple, objective, reliable, and accessible way of predicting mortality in septic patients in the ED or during EH.. After external and clinical validation of e-SEPSS, it could become a useful additional tool in reducing sepsis mortality. |
| format | Article |
| id | doaj-art-8b0ab2b3aafd484fa88e7831129def93 |
| institution | DOAJ |
| issn | 1471-2334 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Infectious Diseases |
| spelling | doaj-art-8b0ab2b3aafd484fa88e7831129def932025-08-20T03:03:27ZengBMCBMC Infectious Diseases1471-23342025-07-0125111210.1186/s12879-025-10920-8A novel scoring system for evaluating mortality risk of patients with sepsis during early hospitalizationIvan Aranza0Miro Vuković1Valentina Biloš2Alen Juginović3Department of Cardiology, University Hospital SplitCenter for Evidence-Based Medicine, University of Split School of MedicineUniversity of Split School of MedicineDepartment of Neurobiology, Harvard Medical SchoolAbstract Background Sepsis is a complex life-threatening condition. Early initiation of treatment is crucial in reducing mortality. Current scoring systems have a lack of reliability in the emergency department (ED) or during early hospitalization (EH). Thus, a quick, reliable, and objective scoring system for assessing mortality risk during EH or ED could significantly reduce sepsis mortality. Methods Using the MIMIC-IV database, we identified 7546 patients hospitalized due to septicemia. We included 13 comorbidity groups and the first chronologically available values of 75 laboratory parameters from the ED or EH. To create and validate our scoring system for early prediction of in-hospital mortality (e-SEPSS), patients were assigned to model development (MD) (N = 1004) or model validation (MV) group (N = 6542), with the latter serving as internal validation of e-SEPSS. Each risk factor that contributed significantly to mortality was assigned one point. Groups with different numbers of points were compared according to mortality and hospitalization duration. Results Decreased chlorides, increased mean corpuscular hemoglobin, increased red blood cell distribution width, increased phosphates, decreased pH, increased partial thromboplastin time, and increased lactate dehydrogenase were included in e-SEPSS due to the highest reliability in predicting mortality. Patients received 1 point for each parameter, creating 8 mortality risk groups. A significant linear increase in mortality with each additional point was shown, ranging from 4.1% (0 points) to 100% (7 points) in the MD group. Similar trends were observed in the MV group. High power in discriminating patients with different mortality risks was shown (MD (ROC AUC = 0.718, CI 0.682–0.754), MV (ROC AUC = 0.798, CI 0.783–0.813)). Decreased survival time and shorter time-to-death with each additional point strengthened the validity of e-SEPSS (Mantel-Cox χ2(7) = 994.2, p-value < 0.001). Conclusion e-SEPSS provides a simple, objective, reliable, and accessible way of predicting mortality in septic patients in the ED or during EH.. After external and clinical validation of e-SEPSS, it could become a useful additional tool in reducing sepsis mortality.https://doi.org/10.1186/s12879-025-10920-8SepsisEarly hospitalizationEmergency departmentChloridesMean corpuscular hemoglobinRed blood cell distribution width |
| spellingShingle | Ivan Aranza Miro Vuković Valentina Biloš Alen Juginović A novel scoring system for evaluating mortality risk of patients with sepsis during early hospitalization BMC Infectious Diseases Sepsis Early hospitalization Emergency department Chlorides Mean corpuscular hemoglobin Red blood cell distribution width |
| title | A novel scoring system for evaluating mortality risk of patients with sepsis during early hospitalization |
| title_full | A novel scoring system for evaluating mortality risk of patients with sepsis during early hospitalization |
| title_fullStr | A novel scoring system for evaluating mortality risk of patients with sepsis during early hospitalization |
| title_full_unstemmed | A novel scoring system for evaluating mortality risk of patients with sepsis during early hospitalization |
| title_short | A novel scoring system for evaluating mortality risk of patients with sepsis during early hospitalization |
| title_sort | novel scoring system for evaluating mortality risk of patients with sepsis during early hospitalization |
| topic | Sepsis Early hospitalization Emergency department Chlorides Mean corpuscular hemoglobin Red blood cell distribution width |
| url | https://doi.org/10.1186/s12879-025-10920-8 |
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