Cancer-associated fibroblast-mediated immune evasion: molecular mechanisms of stromal-immune crosstalk in the tumor microenvironment

Cancer-associated fibroblast-mediated immune evasion: molecular mechanisms of stromal-immune crosstalk in the tumor microenvironment

The tumor microenvironment (TME) is a complex ecosystem and cancer-associated fibroblasts (CAFs) are critical drivers of the immunosuppressive TME. The dynamic interactions between CAFs and immune cells play a crucial role in tumor progression and immune evasion. This review systematically investiga...

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Bibliographic Details
Main Authors: Junling Luo, Xuehua Xiang, Guangyuan Gong, Lang Jiang
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Immunology
Subjects:
cancer-associated fibroblasts
immune evasion
immune cells
tumor microenvironment
CAFs
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1617662/full
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