Maternal urinary concentrations of bisphenol A during pregnancy and birth size in children from the Odense Child Cohort
Abstract Background Bisphenol A (BPA) is widely used in the manufacturing of plastics. BPA can pass the placental barrier and influence fetal development. Due to its estrogenic and anti-androgenic properties, BPA may contribute sex-specific differences in developmental effects. We examined associati...
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2025-04-01
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| Series: | Environmental Health |
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| Online Access: | https://doi.org/10.1186/s12940-025-01169-4 |
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| author | Astrid L. Beck Elvira V. Bräuner Cecilie S. Uldbjerg Youn-Hee Lim Henriette Boye Hanne Frederiksen Anna-Maria Andersson Tina Kold Jensen |
| author_facet | Astrid L. Beck Elvira V. Bräuner Cecilie S. Uldbjerg Youn-Hee Lim Henriette Boye Hanne Frederiksen Anna-Maria Andersson Tina Kold Jensen |
| author_sort | Astrid L. Beck |
| collection | DOAJ |
| description | Abstract Background Bisphenol A (BPA) is widely used in the manufacturing of plastics. BPA can pass the placental barrier and influence fetal development. Due to its estrogenic and anti-androgenic properties, BPA may contribute sex-specific differences in developmental effects. We examined associations between maternal urinary concentrations of BPA and birth size. Methods In this cohort study of 832 mother-child pairs from the Odense Child Cohort, pregnant women provided spot urine samples at gestational week 28, which were analyzed for BPA by isotope diluted LC-MS/MS. Osmolality adjusted urinary BPA concentrations were categorized into quartiles. Mother-child characteristics were obtained from hospital records and questionnaires. Linear regression analyses examining the association between BPA concentrations and offspring birth size (weight, length, head, and abdominal circumference) were performed for the full cohort and stratified by offspring sex. Results BPA was detected above the limit of detection in 85% of the urine samples with a median concentration of 1.33 ng/ml. In the full cohort, birth weight decreased significantly across increasing quartiles of maternal urinary BPA concentration, with the exception of the third quartile, which showed no significant association. In sex-stratified analyses, statistically significant decreases in birth weight were observed among male offspring in the highest quartile of maternal urinary BPA concentrations (β: -115 g, 95% CI: − 225, -4, p = 0.04) compared to male offspring of the lowest quartile and a possible dose-response association was suggested (p-trend = 0.06). No statistically significant associations were observed for birth weight amongst female offspring. Conclusions Our findings suggest a negative association between maternal urinary BPA exposure and birth weight, driven by a lower birth weight in male offspring. Further research is required to explore the underlying mechanisms of BPA’s possible sex-specific associations. |
| format | Article |
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| institution | OA Journals |
| issn | 1476-069X |
| language | English |
| publishDate | 2025-04-01 |
| publisher | BMC |
| record_format | Article |
| series | Environmental Health |
| spelling | doaj-art-8b061af6b0cf47d88f77d63c3707e0ca2025-08-20T01:56:09ZengBMCEnvironmental Health1476-069X2025-04-012411910.1186/s12940-025-01169-4Maternal urinary concentrations of bisphenol A during pregnancy and birth size in children from the Odense Child CohortAstrid L. Beck0Elvira V. Bräuner1Cecilie S. Uldbjerg2Youn-Hee Lim3Henriette Boye4Hanne Frederiksen5Anna-Maria Andersson6Tina Kold Jensen7Department of Growth and Reproduction, Copenhagen University Hospital - RigshospitaletDepartment of Growth and Reproduction, Copenhagen University Hospital - RigshospitaletDepartment of Growth and Reproduction, Copenhagen University Hospital - RigshospitaletSection of Environmental Health, Department of Public Health, University of CopenhagenOdense University Hospital, Hans Christian Andersen Children’s Hospital, Odense Child CohortDepartment of Growth and Reproduction, Copenhagen University Hospital - RigshospitaletDepartment of Growth and Reproduction, Copenhagen University Hospital - RigshospitaletDepartment of Growth and Reproduction, Copenhagen University Hospital - RigshospitaletAbstract Background Bisphenol A (BPA) is widely used in the manufacturing of plastics. BPA can pass the placental barrier and influence fetal development. Due to its estrogenic and anti-androgenic properties, BPA may contribute sex-specific differences in developmental effects. We examined associations between maternal urinary concentrations of BPA and birth size. Methods In this cohort study of 832 mother-child pairs from the Odense Child Cohort, pregnant women provided spot urine samples at gestational week 28, which were analyzed for BPA by isotope diluted LC-MS/MS. Osmolality adjusted urinary BPA concentrations were categorized into quartiles. Mother-child characteristics were obtained from hospital records and questionnaires. Linear regression analyses examining the association between BPA concentrations and offspring birth size (weight, length, head, and abdominal circumference) were performed for the full cohort and stratified by offspring sex. Results BPA was detected above the limit of detection in 85% of the urine samples with a median concentration of 1.33 ng/ml. In the full cohort, birth weight decreased significantly across increasing quartiles of maternal urinary BPA concentration, with the exception of the third quartile, which showed no significant association. In sex-stratified analyses, statistically significant decreases in birth weight were observed among male offspring in the highest quartile of maternal urinary BPA concentrations (β: -115 g, 95% CI: − 225, -4, p = 0.04) compared to male offspring of the lowest quartile and a possible dose-response association was suggested (p-trend = 0.06). No statistically significant associations were observed for birth weight amongst female offspring. Conclusions Our findings suggest a negative association between maternal urinary BPA exposure and birth weight, driven by a lower birth weight in male offspring. Further research is required to explore the underlying mechanisms of BPA’s possible sex-specific associations.https://doi.org/10.1186/s12940-025-01169-4BPAOdense child cohortBirth characteristicsExposureEDCsUrine |
| spellingShingle | Astrid L. Beck Elvira V. Bräuner Cecilie S. Uldbjerg Youn-Hee Lim Henriette Boye Hanne Frederiksen Anna-Maria Andersson Tina Kold Jensen Maternal urinary concentrations of bisphenol A during pregnancy and birth size in children from the Odense Child Cohort Environmental Health BPA Odense child cohort Birth characteristics Exposure EDCs Urine |
| title | Maternal urinary concentrations of bisphenol A during pregnancy and birth size in children from the Odense Child Cohort |
| title_full | Maternal urinary concentrations of bisphenol A during pregnancy and birth size in children from the Odense Child Cohort |
| title_fullStr | Maternal urinary concentrations of bisphenol A during pregnancy and birth size in children from the Odense Child Cohort |
| title_full_unstemmed | Maternal urinary concentrations of bisphenol A during pregnancy and birth size in children from the Odense Child Cohort |
| title_short | Maternal urinary concentrations of bisphenol A during pregnancy and birth size in children from the Odense Child Cohort |
| title_sort | maternal urinary concentrations of bisphenol a during pregnancy and birth size in children from the odense child cohort |
| topic | BPA Odense child cohort Birth characteristics Exposure EDCs Urine |
| url | https://doi.org/10.1186/s12940-025-01169-4 |
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