Lipomembranous fat necrosis of the subcutaneous tissue − a distinct entity with diverse etiologies: A case report with review of the literature
Lipomembranous fat necrosis (LFN) is a term used to describe a distinctive alteration of the fatty tissue, which may be primary or associated with other systemic diseases. It is characterized by fatty cysts of various sizes in the subcutaneous tissue lined by a wavy eosinophilic hyaline membrane, fo...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2024-08-01
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| Series: | Journal of the Egyptian Women’s Dermatologic Society |
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| Online Access: | https://journals.lww.com/10.4103/jewd.jewd_10_24 |
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| author | Padubidri Kombettu Ashwini Namratha Ravishankar Prathyusha Papishetty Veeranna Shastry |
| author_facet | Padubidri Kombettu Ashwini Namratha Ravishankar Prathyusha Papishetty Veeranna Shastry |
| author_sort | Padubidri Kombettu Ashwini |
| collection | DOAJ |
| description | Lipomembranous fat necrosis (LFN) is a term used to describe a distinctive alteration of the fatty tissue, which may be primary or associated with other systemic diseases. It is characterized by fatty cysts of various sizes in the subcutaneous tissue lined by a wavy eosinophilic hyaline membrane, forming pseudopapillary membrane projections into the cysts. This specialized type of necrosis of the adipose tissue has been reported as a focal phenomenon and, rarely, as an extensive one in several pathologies of the subcutaneous tissue. We describe a case of a 41-year-old female with systemic sclerosis who was incidentally also found to have venous insufficiency, who presented with painful dark raised lesions over both legs associated with thickening of the subcutaneous fat tissue. Biopsy and histopathological examination revealed LFN with features of stasis dermatitis. Through this case report, we discuss the clinicopathological features of this phenomenon to highlight this presentation of LFN in association with two predisposing conditions, to review the associated literature and to postulate the pathogenic mechanisms leading to this phenomenon. |
| format | Article |
| id | doaj-art-8b02a67f567449d795ae9f4416e40153 |
| institution | OA Journals |
| issn | 2090-2565 |
| language | English |
| publishDate | 2024-08-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of the Egyptian Women’s Dermatologic Society |
| spelling | doaj-art-8b02a67f567449d795ae9f4416e401532025-08-20T02:01:19ZengWolters Kluwer Medknow PublicationsJournal of the Egyptian Women’s Dermatologic Society2090-25652024-08-0121325025510.4103/jewd.jewd_10_24Lipomembranous fat necrosis of the subcutaneous tissue − a distinct entity with diverse etiologies: A case report with review of the literaturePadubidri Kombettu AshwiniNamratha RavishankarPrathyusha PapishettyVeeranna ShastryLipomembranous fat necrosis (LFN) is a term used to describe a distinctive alteration of the fatty tissue, which may be primary or associated with other systemic diseases. It is characterized by fatty cysts of various sizes in the subcutaneous tissue lined by a wavy eosinophilic hyaline membrane, forming pseudopapillary membrane projections into the cysts. This specialized type of necrosis of the adipose tissue has been reported as a focal phenomenon and, rarely, as an extensive one in several pathologies of the subcutaneous tissue. We describe a case of a 41-year-old female with systemic sclerosis who was incidentally also found to have venous insufficiency, who presented with painful dark raised lesions over both legs associated with thickening of the subcutaneous fat tissue. Biopsy and histopathological examination revealed LFN with features of stasis dermatitis. Through this case report, we discuss the clinicopathological features of this phenomenon to highlight this presentation of LFN in association with two predisposing conditions, to review the associated literature and to postulate the pathogenic mechanisms leading to this phenomenon.https://journals.lww.com/10.4103/jewd.jewd_10_24panniculitisskin biopsysystemic sclerosisvenous insufficiency |
| spellingShingle | Padubidri Kombettu Ashwini Namratha Ravishankar Prathyusha Papishetty Veeranna Shastry Lipomembranous fat necrosis of the subcutaneous tissue − a distinct entity with diverse etiologies: A case report with review of the literature Journal of the Egyptian Women’s Dermatologic Society panniculitis skin biopsy systemic sclerosis venous insufficiency |
| title | Lipomembranous fat necrosis of the subcutaneous tissue − a distinct entity with diverse etiologies: A case report with review of the literature |
| title_full | Lipomembranous fat necrosis of the subcutaneous tissue − a distinct entity with diverse etiologies: A case report with review of the literature |
| title_fullStr | Lipomembranous fat necrosis of the subcutaneous tissue − a distinct entity with diverse etiologies: A case report with review of the literature |
| title_full_unstemmed | Lipomembranous fat necrosis of the subcutaneous tissue − a distinct entity with diverse etiologies: A case report with review of the literature |
| title_short | Lipomembranous fat necrosis of the subcutaneous tissue − a distinct entity with diverse etiologies: A case report with review of the literature |
| title_sort | lipomembranous fat necrosis of the subcutaneous tissue a distinct entity with diverse etiologies a case report with review of the literature |
| topic | panniculitis skin biopsy systemic sclerosis venous insufficiency |
| url | https://journals.lww.com/10.4103/jewd.jewd_10_24 |
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