Epigenetic control of tissue resident memory T cells
Tissue-resident memory T cells (TRM) represent a heterogeneous population of T cells that exhibit both effector and memory functionalities. They express specific gene signatures that enable them to occupy tissues without recirculating, thus providing a first response against reencountered pathogens...
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Frontiers Media S.A.
2025-08-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1605972/full |
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| author | Zhiyi Lan Zhiyi Lan Zhiyi Lan Zeyu Chen Zeyu Chen Nan Yang Nan Yang Tong Liu Tong Liu Siqi Li Siqi Li Yuling Shi Yuling Shi Jun Gu Jun Gu |
| author_facet | Zhiyi Lan Zhiyi Lan Zhiyi Lan Zeyu Chen Zeyu Chen Nan Yang Nan Yang Tong Liu Tong Liu Siqi Li Siqi Li Yuling Shi Yuling Shi Jun Gu Jun Gu |
| author_sort | Zhiyi Lan |
| collection | DOAJ |
| description | Tissue-resident memory T cells (TRM) represent a heterogeneous population of T cells that exhibit both effector and memory functionalities. They express specific gene signatures that enable them to occupy tissues without recirculating, thus providing a first response against reencountered pathogens or antigens. TRM have been implicated in the pathogenesis of various diseases, including autoimmune disorders, infections, and cancers. This has prompted interest in targeting TRM as a potential therapeutic strategy. Epigenetic modifications, which frequently occur in immune cells across various disease states, play a significant role not only in tissue homeostasis but also in disease progression. Emerging evidence suggests that the epigenetic landscape of TRM is altered in pathogenic conditions, impacting their differentiation, maintenance, and function. Nevertheless, the precise mechanisms remain poorly understood. This review seeks to provide a comprehensive overview of the epigenetic regulation of TRM, focusing on key areas such as chromatin accessibility, DNA methylation, histone modifications, and non-coding RNAs. Importantly, a deeper understanding of these epigenetic mechanisms will pave the way for novel therapeutic strategies, such as modulating TRM activity in autoimmune diseases, enhancing tissue-specific immunity through vaccines, or improving immunotherapeutic efficacy in cancer. |
| format | Article |
| id | doaj-art-8b017bcc95ee4eb1812e460ecf8843a8 |
| institution | DOAJ |
| issn | 1664-3224 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj-art-8b017bcc95ee4eb1812e460ecf8843a82025-08-20T03:05:45ZengFrontiers Media S.A.Frontiers in Immunology1664-32242025-08-011610.3389/fimmu.2025.16059721605972Epigenetic control of tissue resident memory T cellsZhiyi Lan0Zhiyi Lan1Zhiyi Lan2Zeyu Chen3Zeyu Chen4Nan Yang5Nan Yang6Tong Liu7Tong Liu8Siqi Li9Siqi Li10Yuling Shi11Yuling Shi12Jun Gu13Jun Gu14Department of Dermatology, Shanghai Skin Disease Hospital, Tongji University School of Medicine, Shanghai, ChinaInstitute of Psoriasis, Tongji University School of Medicine, Shanghai, ChinaDepartment of Dermatology, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai, ChinaDepartment of Dermatology, Shanghai Skin Disease Hospital, Tongji University School of Medicine, Shanghai, ChinaInstitute of Psoriasis, Tongji University School of Medicine, Shanghai, ChinaDepartment of Dermatology, Shanghai Skin Disease Hospital, Tongji University School of Medicine, Shanghai, ChinaInstitute of Psoriasis, Tongji University School of Medicine, Shanghai, ChinaDepartment of Dermatology, Shanghai Skin Disease Hospital, Tongji University School of Medicine, Shanghai, ChinaInstitute of Psoriasis, Tongji University School of Medicine, Shanghai, ChinaDepartment of Dermatology, Shanghai Skin Disease Hospital, Tongji University School of Medicine, Shanghai, ChinaInstitute of Psoriasis, Tongji University School of Medicine, Shanghai, ChinaDepartment of Dermatology, Shanghai Skin Disease Hospital, Tongji University School of Medicine, Shanghai, ChinaInstitute of Psoriasis, Tongji University School of Medicine, Shanghai, ChinaInstitute of Psoriasis, Tongji University School of Medicine, Shanghai, ChinaDepartment of Dermatology, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai, ChinaTissue-resident memory T cells (TRM) represent a heterogeneous population of T cells that exhibit both effector and memory functionalities. They express specific gene signatures that enable them to occupy tissues without recirculating, thus providing a first response against reencountered pathogens or antigens. TRM have been implicated in the pathogenesis of various diseases, including autoimmune disorders, infections, and cancers. This has prompted interest in targeting TRM as a potential therapeutic strategy. Epigenetic modifications, which frequently occur in immune cells across various disease states, play a significant role not only in tissue homeostasis but also in disease progression. Emerging evidence suggests that the epigenetic landscape of TRM is altered in pathogenic conditions, impacting their differentiation, maintenance, and function. Nevertheless, the precise mechanisms remain poorly understood. This review seeks to provide a comprehensive overview of the epigenetic regulation of TRM, focusing on key areas such as chromatin accessibility, DNA methylation, histone modifications, and non-coding RNAs. Importantly, a deeper understanding of these epigenetic mechanisms will pave the way for novel therapeutic strategies, such as modulating TRM activity in autoimmune diseases, enhancing tissue-specific immunity through vaccines, or improving immunotherapeutic efficacy in cancer.https://www.frontiersin.org/articles/10.3389/fimmu.2025.1605972/fulltissue resident memory T cellsepigeneticschromatin accessibilityDNA methylationhistone modificationnon-coding RNAs |
| spellingShingle | Zhiyi Lan Zhiyi Lan Zhiyi Lan Zeyu Chen Zeyu Chen Nan Yang Nan Yang Tong Liu Tong Liu Siqi Li Siqi Li Yuling Shi Yuling Shi Jun Gu Jun Gu Epigenetic control of tissue resident memory T cells Frontiers in Immunology tissue resident memory T cells epigenetics chromatin accessibility DNA methylation histone modification non-coding RNAs |
| title | Epigenetic control of tissue resident memory T cells |
| title_full | Epigenetic control of tissue resident memory T cells |
| title_fullStr | Epigenetic control of tissue resident memory T cells |
| title_full_unstemmed | Epigenetic control of tissue resident memory T cells |
| title_short | Epigenetic control of tissue resident memory T cells |
| title_sort | epigenetic control of tissue resident memory t cells |
| topic | tissue resident memory T cells epigenetics chromatin accessibility DNA methylation histone modification non-coding RNAs |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1605972/full |
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