Obesity Increases Prevalence of Colonic Adenomas at Screening Colonoscopy: A Canadian Community-Based Study
Background and Aims. Obesity is a risk factor for colorectal neoplasia. We examined the influence of obesity and metabolic syndrome (MetS) on prevalence of neoplasia at screening colonoscopy. Methods. We evaluated 2020 subjects undergoing first screening colonoscopy. Body mass index (BMI) was calcul...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Canadian Journal of Gastroenterology and Hepatology |
| Online Access: | http://dx.doi.org/10.1155/2017/8750967 |
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| author | Theodore F. Shapero Grant I. Chen Tim Devlin Alison Gibbs Iain C. Murray Stanley Tran Corey Weigensberg |
| author_facet | Theodore F. Shapero Grant I. Chen Tim Devlin Alison Gibbs Iain C. Murray Stanley Tran Corey Weigensberg |
| author_sort | Theodore F. Shapero |
| collection | DOAJ |
| description | Background and Aims. Obesity is a risk factor for colorectal neoplasia. We examined the influence of obesity and metabolic syndrome (MetS) on prevalence of neoplasia at screening colonoscopy. Methods. We evaluated 2020 subjects undergoing first screening colonoscopy. Body mass index (BMI) was calculated at enrolment. Hyperlipidemia (HL), hypertension (HT), and diabetes mellitus (DM) were identified. Details of colonoscopy, polypectomy, and histology were recorded. Odds for adenomas (A) and advanced adenomas (ADV) in overweight (BMI 25.1–30) and obese (BMI > 30) subjects were assessed by multinomial regression, adjusted for covariates. Analyses included relationships between HL, HT, DM, age, tobacco usage, and neoplasia. Discriminatory power of HT, HL, DM, and BMI for neoplasia was assessed by binary logistic regression. Odds were calculated for neoplasia in each colonic segment related to BMI. Results. A and ADV were commoner in overweight and obese males, obese females, older subjects, and smokers. HL, HT, and DM were associated with increased odds for neoplasia, significantly for A with hypertension. BMI alone predicted neoplasia as well as HT, HL, DM, or combinations thereof. All segments of the colon were affected. Multiple polyps were particularly prevalent in the obese. Conclusions. Obesity and MetS are risk factors for colonic neoplasia in a Canadian population. |
| format | Article |
| id | doaj-art-8af84a3c18814abe991c95082d6b8484 |
| institution | Kabale University |
| issn | 2291-2789 2291-2797 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Canadian Journal of Gastroenterology and Hepatology |
| spelling | doaj-art-8af84a3c18814abe991c95082d6b84842025-02-03T01:08:59ZengWileyCanadian Journal of Gastroenterology and Hepatology2291-27892291-27972017-01-01201710.1155/2017/87509678750967Obesity Increases Prevalence of Colonic Adenomas at Screening Colonoscopy: A Canadian Community-Based StudyTheodore F. Shapero0Grant I. Chen1Tim Devlin2Alison Gibbs3Iain C. Murray4Stanley Tran5Corey Weigensberg6Department of Medicine, The Scarborough Hospital, Scarborough, ON, CanadaDepartment of Medicine, The Scarborough Hospital, Scarborough, ON, CanadaDepartment of Medicine, The Scarborough Hospital, Scarborough, ON, CanadaDepartment of Statistical Sciences, University of Toronto, Toronto, ON, CanadaIntestinal Health Institute, Markham, ON, CanadaDepartment of Medicine, The Scarborough Hospital and North Toronto Endoscopy Clinic, Scarborough, ON, CanadaDepartment of Pathology, The Scarborough Hospital, Scarborough, ON, CanadaBackground and Aims. Obesity is a risk factor for colorectal neoplasia. We examined the influence of obesity and metabolic syndrome (MetS) on prevalence of neoplasia at screening colonoscopy. Methods. We evaluated 2020 subjects undergoing first screening colonoscopy. Body mass index (BMI) was calculated at enrolment. Hyperlipidemia (HL), hypertension (HT), and diabetes mellitus (DM) were identified. Details of colonoscopy, polypectomy, and histology were recorded. Odds for adenomas (A) and advanced adenomas (ADV) in overweight (BMI 25.1–30) and obese (BMI > 30) subjects were assessed by multinomial regression, adjusted for covariates. Analyses included relationships between HL, HT, DM, age, tobacco usage, and neoplasia. Discriminatory power of HT, HL, DM, and BMI for neoplasia was assessed by binary logistic regression. Odds were calculated for neoplasia in each colonic segment related to BMI. Results. A and ADV were commoner in overweight and obese males, obese females, older subjects, and smokers. HL, HT, and DM were associated with increased odds for neoplasia, significantly for A with hypertension. BMI alone predicted neoplasia as well as HT, HL, DM, or combinations thereof. All segments of the colon were affected. Multiple polyps were particularly prevalent in the obese. Conclusions. Obesity and MetS are risk factors for colonic neoplasia in a Canadian population.http://dx.doi.org/10.1155/2017/8750967 |
| spellingShingle | Theodore F. Shapero Grant I. Chen Tim Devlin Alison Gibbs Iain C. Murray Stanley Tran Corey Weigensberg Obesity Increases Prevalence of Colonic Adenomas at Screening Colonoscopy: A Canadian Community-Based Study Canadian Journal of Gastroenterology and Hepatology |
| title | Obesity Increases Prevalence of Colonic Adenomas at Screening Colonoscopy: A Canadian Community-Based Study |
| title_full | Obesity Increases Prevalence of Colonic Adenomas at Screening Colonoscopy: A Canadian Community-Based Study |
| title_fullStr | Obesity Increases Prevalence of Colonic Adenomas at Screening Colonoscopy: A Canadian Community-Based Study |
| title_full_unstemmed | Obesity Increases Prevalence of Colonic Adenomas at Screening Colonoscopy: A Canadian Community-Based Study |
| title_short | Obesity Increases Prevalence of Colonic Adenomas at Screening Colonoscopy: A Canadian Community-Based Study |
| title_sort | obesity increases prevalence of colonic adenomas at screening colonoscopy a canadian community based study |
| url | http://dx.doi.org/10.1155/2017/8750967 |
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