Establishing a Prediction Model for Weight Loss Outcomes After LSG in Chinese Obese Patients with BMI ≥ 32.5 Kg/m2 Using Body Composition Data
Liang Wang,* Yilan Sun,* Qing Sang,* Zheng Wang, Chengyuan Yu, Zhehong Li, Mingyue Shang, Nengwei Zhang, Dexiao Du Surgery Centre of Diabetes Mellitus, Capital Medical University Affiliated Beijing Shijitan Hospital, Beijing, 100038, People’s Republic of China&...
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Dove Medical Press
2025-05-01
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| Series: | Diabetes, Metabolic Syndrome and Obesity |
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| author | Wang L Sun Y Sang Q Wang Z Yu C Li Z Shang M Zhang N Du D |
| author_facet | Wang L Sun Y Sang Q Wang Z Yu C Li Z Shang M Zhang N Du D |
| author_sort | Wang L |
| collection | DOAJ |
| description | Liang Wang,* Yilan Sun,* Qing Sang,* Zheng Wang, Chengyuan Yu, Zhehong Li, Mingyue Shang, Nengwei Zhang, Dexiao Du Surgery Centre of Diabetes Mellitus, Capital Medical University Affiliated Beijing Shijitan Hospital, Beijing, 100038, People’s Republic of China*These authors contributed equally to this workCorrespondence: Nengwei Zhang, Shijitan Hospital, Tieyi Road, Haidian District, Beijing, People’s Republic of China, Tel +8613801068802, Email zhangnw@ccmu.edu.cn Dexiao Du, Shijitan Hospital, Tieyi Road, Haidian District, Beijing, People’s Republic of China, Tel +8613581753721, Email dudexiao@sohu.comBackground: Laparoscopic sleeve gastrectomy (LSG) is associated with sustained and substantial weight loss. However, suboptimal results are observed in certain patients.Objective: Drawing from body composition data at our center, clinically accessible predictive factors for weight loss outcomes were identified, leading to the development and validation of a preoperative predictive model for weight loss following LSG.Methods and Materials: A retrospective analysis was conducted on the general clinical baseline and body composition data of obese patients (body mass index [BMI] ≥ 32.5 kg/m2) who underwent LSG between December 2016 and December 2022. Independent predictors for weight loss outcomes were selected through univariate logistic regression, random forest analysis, and multivariate logistic regression. Subsequently, a nomogram was developed to predict weight loss outcomes and was evaluated for discrimination, accuracy, and clinical utility, with validation performed in a separate cohort.Results: A total of 473 patients with mean BMI were included. The preoperative resting energy expenditure to body weight ratio (REE/BW), fat-free mass index (FFMI), and waist circumference (WC) emerged as independent predictive factors for weight loss outcomes at one year post-LSG. These body composition parameters were incorporated into the construction of an Inbody predictive nomogram, which yielded area under the curve (AUC) values of 0.868 (95% CI: 0.826– 0.902) for the modeling cohort and 0.829 (95% CI: 0.756– 0.887) for the validation cohort. Calibration curves, decision curve analysis (DCA), and clinical impact curves (CIC) from both groups demonstrated the model’s robust discrimination, accuracy, and clinical utility.Conclusion: In obese Chinese patients with a BMI ≥ 32.5 kg/m2, the Inbody-based nomogram integrating REE/BW, FFMI, and WC offers an effective preoperative tool for predicting weight loss outcomes one year after LSG, facilitating surgical planning and postoperative management.Keywords: laparoscopic sleeve gastrectomy, prognostic prediction, metabolic bariatric surgery, obesity, body composition data |
| format | Article |
| id | doaj-art-8af5ca6f77b44050906a44d9d4e4c96a |
| institution | DOAJ |
| issn | 1178-7007 |
| language | English |
| publishDate | 2025-05-01 |
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| series | Diabetes, Metabolic Syndrome and Obesity |
| spelling | doaj-art-8af5ca6f77b44050906a44d9d4e4c96a2025-08-20T03:09:32ZengDove Medical PressDiabetes, Metabolic Syndrome and Obesity1178-70072025-05-01Volume 18Issue 114671487102753Establishing a Prediction Model for Weight Loss Outcomes After LSG in Chinese Obese Patients with BMI ≥ 32.5 Kg/m2 Using Body Composition DataWang LSun Y0Sang QWang ZYu CLi ZShang MZhang N1Du DCapital Medical UniversitySurgery Centre of Diabetes MellitusLiang Wang,* Yilan Sun,* Qing Sang,* Zheng Wang, Chengyuan Yu, Zhehong Li, Mingyue Shang, Nengwei Zhang, Dexiao Du Surgery Centre of Diabetes Mellitus, Capital Medical University Affiliated Beijing Shijitan Hospital, Beijing, 100038, People’s Republic of China*These authors contributed equally to this workCorrespondence: Nengwei Zhang, Shijitan Hospital, Tieyi Road, Haidian District, Beijing, People’s Republic of China, Tel +8613801068802, Email zhangnw@ccmu.edu.cn Dexiao Du, Shijitan Hospital, Tieyi Road, Haidian District, Beijing, People’s Republic of China, Tel +8613581753721, Email dudexiao@sohu.comBackground: Laparoscopic sleeve gastrectomy (LSG) is associated with sustained and substantial weight loss. However, suboptimal results are observed in certain patients.Objective: Drawing from body composition data at our center, clinically accessible predictive factors for weight loss outcomes were identified, leading to the development and validation of a preoperative predictive model for weight loss following LSG.Methods and Materials: A retrospective analysis was conducted on the general clinical baseline and body composition data of obese patients (body mass index [BMI] ≥ 32.5 kg/m2) who underwent LSG between December 2016 and December 2022. Independent predictors for weight loss outcomes were selected through univariate logistic regression, random forest analysis, and multivariate logistic regression. Subsequently, a nomogram was developed to predict weight loss outcomes and was evaluated for discrimination, accuracy, and clinical utility, with validation performed in a separate cohort.Results: A total of 473 patients with mean BMI were included. The preoperative resting energy expenditure to body weight ratio (REE/BW), fat-free mass index (FFMI), and waist circumference (WC) emerged as independent predictive factors for weight loss outcomes at one year post-LSG. These body composition parameters were incorporated into the construction of an Inbody predictive nomogram, which yielded area under the curve (AUC) values of 0.868 (95% CI: 0.826– 0.902) for the modeling cohort and 0.829 (95% CI: 0.756– 0.887) for the validation cohort. Calibration curves, decision curve analysis (DCA), and clinical impact curves (CIC) from both groups demonstrated the model’s robust discrimination, accuracy, and clinical utility.Conclusion: In obese Chinese patients with a BMI ≥ 32.5 kg/m2, the Inbody-based nomogram integrating REE/BW, FFMI, and WC offers an effective preoperative tool for predicting weight loss outcomes one year after LSG, facilitating surgical planning and postoperative management.Keywords: laparoscopic sleeve gastrectomy, prognostic prediction, metabolic bariatric surgery, obesity, body composition datahttps://www.dovepress.com/establishing-a-prediction-model-for-weight-loss-outcomes-after-lsg-in--peer-reviewed-fulltext-article-DMSOLaparoscopic Sleeve GastrectomyPrognostic PredictionMetabolic bariatric sutgeryObesityBody Composition Data. |
| spellingShingle | Wang L Sun Y Sang Q Wang Z Yu C Li Z Shang M Zhang N Du D Establishing a Prediction Model for Weight Loss Outcomes After LSG in Chinese Obese Patients with BMI ≥ 32.5 Kg/m2 Using Body Composition Data Diabetes, Metabolic Syndrome and Obesity Laparoscopic Sleeve Gastrectomy Prognostic Prediction Metabolic bariatric sutgery Obesity Body Composition Data. |
| title | Establishing a Prediction Model for Weight Loss Outcomes After LSG in Chinese Obese Patients with BMI ≥ 32.5 Kg/m2 Using Body Composition Data |
| title_full | Establishing a Prediction Model for Weight Loss Outcomes After LSG in Chinese Obese Patients with BMI ≥ 32.5 Kg/m2 Using Body Composition Data |
| title_fullStr | Establishing a Prediction Model for Weight Loss Outcomes After LSG in Chinese Obese Patients with BMI ≥ 32.5 Kg/m2 Using Body Composition Data |
| title_full_unstemmed | Establishing a Prediction Model for Weight Loss Outcomes After LSG in Chinese Obese Patients with BMI ≥ 32.5 Kg/m2 Using Body Composition Data |
| title_short | Establishing a Prediction Model for Weight Loss Outcomes After LSG in Chinese Obese Patients with BMI ≥ 32.5 Kg/m2 Using Body Composition Data |
| title_sort | establishing a prediction model for weight loss outcomes after lsg in chinese obese patients with bmi amp ge 32 5 kg m2 using body composition data |
| topic | Laparoscopic Sleeve Gastrectomy Prognostic Prediction Metabolic bariatric sutgery Obesity Body Composition Data. |
| url | https://www.dovepress.com/establishing-a-prediction-model-for-weight-loss-outcomes-after-lsg-in--peer-reviewed-fulltext-article-DMSO |
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