Ciliary Ion Channels in Polycystic Kidney Disease
Polycystic kidney disease (PKD) is the most common hereditary disorder that disrupts renal function and frequently progresses to end-stage renal disease. Recent advances have elucidated the critical role of primary cilia and ciliary ion channels, including transient receptor potential (TRP) channels...
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MDPI AG
2025-03-01
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| author | Lubna A. Alshriem Raghad Buqaileh Qasim Alorjani Wissam AbouAlaiwi |
| author_facet | Lubna A. Alshriem Raghad Buqaileh Qasim Alorjani Wissam AbouAlaiwi |
| author_sort | Lubna A. Alshriem |
| collection | DOAJ |
| description | Polycystic kidney disease (PKD) is the most common hereditary disorder that disrupts renal function and frequently progresses to end-stage renal disease. Recent advances have elucidated the critical role of primary cilia and ciliary ion channels, including transient receptor potential (TRP) channels, cystic fibrosis transmembrane conductance regulator (CFTR), and polycystin channels, in the pathogenesis of PKD. While some channels primarily function as chloride conductance channels (e.g., CFTR), others primarily regulate calcium (Ca<sup>+2</sup>) homeostasis. These ion channels are essential for cellular signaling and maintaining the normal kidney architecture. Dysregulation of these pathways due to genetic mutations in <i>PKD1</i> and <i>PKD2</i> leads to disrupted Ca<sup>+2</sup> and cAMP signaling, aberrant fluid secretion, and uncontrolled cellular proliferation, resulting in tubular cystogenesis. Understanding the molecular mechanisms underlying these dysfunctions has opened the door for innovative therapeutic strategies, including TRPV4 activators, CFTR inhibitors, and calcimimetics, to mitigate cyst growth and preserve renal function. This review summarizes the current knowledge on the roles of ciliary ion channels in PKD pathophysiology, highlights therapeutic interventions targeting these channels, and identifies future research directions for improving patient outcomes. |
| format | Article |
| id | doaj-art-8af110669adc4b2e93c252000e77b6e7 |
| institution | DOAJ |
| issn | 2073-4409 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj-art-8af110669adc4b2e93c252000e77b6e72025-08-20T02:42:35ZengMDPI AGCells2073-44092025-03-0114645910.3390/cells14060459Ciliary Ion Channels in Polycystic Kidney DiseaseLubna A. Alshriem0Raghad Buqaileh1Qasim Alorjani2Wissam AbouAlaiwi3Department of Pharmacology and Experimental Therapeutics, University of Toledo, Toledo, OH 43614, USADepartment of Pharmacology and Experimental Therapeutics, University of Toledo, Toledo, OH 43614, USADepartment of Pharmacology and Experimental Therapeutics, University of Toledo, Toledo, OH 43614, USADepartment of Pharmacology and Experimental Therapeutics, University of Toledo, Toledo, OH 43614, USAPolycystic kidney disease (PKD) is the most common hereditary disorder that disrupts renal function and frequently progresses to end-stage renal disease. Recent advances have elucidated the critical role of primary cilia and ciliary ion channels, including transient receptor potential (TRP) channels, cystic fibrosis transmembrane conductance regulator (CFTR), and polycystin channels, in the pathogenesis of PKD. While some channels primarily function as chloride conductance channels (e.g., CFTR), others primarily regulate calcium (Ca<sup>+2</sup>) homeostasis. These ion channels are essential for cellular signaling and maintaining the normal kidney architecture. Dysregulation of these pathways due to genetic mutations in <i>PKD1</i> and <i>PKD2</i> leads to disrupted Ca<sup>+2</sup> and cAMP signaling, aberrant fluid secretion, and uncontrolled cellular proliferation, resulting in tubular cystogenesis. Understanding the molecular mechanisms underlying these dysfunctions has opened the door for innovative therapeutic strategies, including TRPV4 activators, CFTR inhibitors, and calcimimetics, to mitigate cyst growth and preserve renal function. This review summarizes the current knowledge on the roles of ciliary ion channels in PKD pathophysiology, highlights therapeutic interventions targeting these channels, and identifies future research directions for improving patient outcomes.https://www.mdpi.com/2073-4409/14/6/459polycystic kidney diseaseprimary ciliaion channelspolycystinCa<sup>+2</sup>TRPV4 |
| spellingShingle | Lubna A. Alshriem Raghad Buqaileh Qasim Alorjani Wissam AbouAlaiwi Ciliary Ion Channels in Polycystic Kidney Disease Cells polycystic kidney disease primary cilia ion channels polycystin Ca<sup>+2</sup> TRPV4 |
| title | Ciliary Ion Channels in Polycystic Kidney Disease |
| title_full | Ciliary Ion Channels in Polycystic Kidney Disease |
| title_fullStr | Ciliary Ion Channels in Polycystic Kidney Disease |
| title_full_unstemmed | Ciliary Ion Channels in Polycystic Kidney Disease |
| title_short | Ciliary Ion Channels in Polycystic Kidney Disease |
| title_sort | ciliary ion channels in polycystic kidney disease |
| topic | polycystic kidney disease primary cilia ion channels polycystin Ca<sup>+2</sup> TRPV4 |
| url | https://www.mdpi.com/2073-4409/14/6/459 |
| work_keys_str_mv | AT lubnaaalshriem ciliaryionchannelsinpolycystickidneydisease AT raghadbuqaileh ciliaryionchannelsinpolycystickidneydisease AT qasimalorjani ciliaryionchannelsinpolycystickidneydisease AT wissamaboualaiwi ciliaryionchannelsinpolycystickidneydisease |