Thermodynamic Behavior of Erythromycin Thiocyanate Dihydrate in Six Pure Solvents and Two Binary Solvents
Thermodynamic parameters play a crucial role in analyzing and optimizing crystallization processes. In this investigation, the solubility profiles of erythromycin thiocyanate dihydrate were determined gravimetrically under atmospheric pressure (0.1 MPa) across six monosolvent systems (methanol, n-pr...
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2025-05-01
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| author | Jin Feng Xunhui Li Lianjie Zhai Peizhou Li Ting Qin Na Wang Lu Zhou Baoxin Zhang Ting Wang Xin Huang Hongxun Hao |
| author_facet | Jin Feng Xunhui Li Lianjie Zhai Peizhou Li Ting Qin Na Wang Lu Zhou Baoxin Zhang Ting Wang Xin Huang Hongxun Hao |
| author_sort | Jin Feng |
| collection | DOAJ |
| description | Thermodynamic parameters play a crucial role in analyzing and optimizing crystallization processes. In this investigation, the solubility profiles of erythromycin thiocyanate dihydrate were determined gravimetrically under atmospheric pressure (0.1 MPa) across six monosolvent systems (methanol, n-propanol, methyl acetate, ethyl acetate, propyl acetate, and water) and two binary solvent mixtures (water–methanol and water–n-propanol), spanning a temperature range of 278.15–318.15 K. The results showed that the solubility of erythromycin thiocyanate dihydrate is apparently affected by temperature and solvent type. For pure solvents, erythromycin thiocyanate dihydrate has higher solubility in alcohol solvents, and lower solubility in ester solvents and water. In mixed solvent systems, erythromycin thiocyanate dihydrate exhibits reduced solubility with higher water content. The experimental solubility values in monosolvent systems were correlated using the Apelblat, Yaws, and Van’t Hoff models, with the Apelblat model showing the best fitting effect. The Apelblat model, Apelblat Jouyban Acre model, and CNIBS/R-K model were employed for data correlation in binary solvent systems, with the Apelblat model and CNIBS/R-K model showing better fitting results. |
| format | Article |
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| institution | DOAJ |
| issn | 1420-3049 |
| language | English |
| publishDate | 2025-05-01 |
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| series | Molecules |
| spelling | doaj-art-8ae7dee9e94e4a389f5cf3674c986ada2025-08-20T03:11:19ZengMDPI AGMolecules1420-30492025-05-013011242410.3390/molecules30112424Thermodynamic Behavior of Erythromycin Thiocyanate Dihydrate in Six Pure Solvents and Two Binary SolventsJin Feng0Xunhui Li1Lianjie Zhai2Peizhou Li3Ting Qin4Na Wang5Lu Zhou6Baoxin Zhang7Ting Wang8Xin Huang9Hongxun Hao10National Engineering Research Center for Industrial Crystallization Technology, School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, ChinaNational Engineering Research Center for Industrial Crystallization Technology, School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, ChinaXi’an Modern Chemistry Research Institute, Xi’an 710065, ChinaCollege of Chemistry and Chemical Engineering, Hainan University, Haikou 570228, ChinaNational Engineering Research Center for Industrial Crystallization Technology, School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, ChinaNational Engineering Research Center for Industrial Crystallization Technology, School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, ChinaYili Chuanning Biotechnology Co., Ltd., Yili 835000, ChinaYili Chuanning Biotechnology Co., Ltd., Yili 835000, ChinaNational Engineering Research Center for Industrial Crystallization Technology, School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, ChinaNational Engineering Research Center for Industrial Crystallization Technology, School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, ChinaNational Engineering Research Center for Industrial Crystallization Technology, School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, ChinaThermodynamic parameters play a crucial role in analyzing and optimizing crystallization processes. In this investigation, the solubility profiles of erythromycin thiocyanate dihydrate were determined gravimetrically under atmospheric pressure (0.1 MPa) across six monosolvent systems (methanol, n-propanol, methyl acetate, ethyl acetate, propyl acetate, and water) and two binary solvent mixtures (water–methanol and water–n-propanol), spanning a temperature range of 278.15–318.15 K. The results showed that the solubility of erythromycin thiocyanate dihydrate is apparently affected by temperature and solvent type. For pure solvents, erythromycin thiocyanate dihydrate has higher solubility in alcohol solvents, and lower solubility in ester solvents and water. In mixed solvent systems, erythromycin thiocyanate dihydrate exhibits reduced solubility with higher water content. The experimental solubility values in monosolvent systems were correlated using the Apelblat, Yaws, and Van’t Hoff models, with the Apelblat model showing the best fitting effect. The Apelblat model, Apelblat Jouyban Acre model, and CNIBS/R-K model were employed for data correlation in binary solvent systems, with the Apelblat model and CNIBS/R-K model showing better fitting results.https://www.mdpi.com/1420-3049/30/11/2424erythromycin thiocyanate dihydratethermodynamic behaviorsolubility |
| spellingShingle | Jin Feng Xunhui Li Lianjie Zhai Peizhou Li Ting Qin Na Wang Lu Zhou Baoxin Zhang Ting Wang Xin Huang Hongxun Hao Thermodynamic Behavior of Erythromycin Thiocyanate Dihydrate in Six Pure Solvents and Two Binary Solvents Molecules erythromycin thiocyanate dihydrate thermodynamic behavior solubility |
| title | Thermodynamic Behavior of Erythromycin Thiocyanate Dihydrate in Six Pure Solvents and Two Binary Solvents |
| title_full | Thermodynamic Behavior of Erythromycin Thiocyanate Dihydrate in Six Pure Solvents and Two Binary Solvents |
| title_fullStr | Thermodynamic Behavior of Erythromycin Thiocyanate Dihydrate in Six Pure Solvents and Two Binary Solvents |
| title_full_unstemmed | Thermodynamic Behavior of Erythromycin Thiocyanate Dihydrate in Six Pure Solvents and Two Binary Solvents |
| title_short | Thermodynamic Behavior of Erythromycin Thiocyanate Dihydrate in Six Pure Solvents and Two Binary Solvents |
| title_sort | thermodynamic behavior of erythromycin thiocyanate dihydrate in six pure solvents and two binary solvents |
| topic | erythromycin thiocyanate dihydrate thermodynamic behavior solubility |
| url | https://www.mdpi.com/1420-3049/30/11/2424 |
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