Type I Interferons: Key Players in Normal Skin and Select Cutaneous Malignancies
Interferons (IFNs) are a family of naturally existing glycoproteins known for their antiviral activity and their ability to influence the behavior of normal and transformed cell types. Type I Interferons include IFN-α and IFN-β. Currently, IFN-α has numerous approved antitumor applications, includin...
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| Format: | Article |
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Wiley
2014-01-01
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| Series: | Dermatology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2014/847545 |
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| author | Aimen Ismail Nabiha Yusuf |
| author_facet | Aimen Ismail Nabiha Yusuf |
| author_sort | Aimen Ismail |
| collection | DOAJ |
| description | Interferons (IFNs) are a family of naturally existing glycoproteins known for their antiviral activity and their ability to influence the behavior of normal and transformed cell types. Type I Interferons include IFN-α and IFN-β. Currently, IFN-α has numerous approved antitumor applications, including malignant melanoma, in which IFN-α has been shown to increase relapse free survival. Moreover, IFN-α has been successfully used in the intralesional treatment of cutaneous squamous cell carcinoma (SCC) and basal cell carcinoma (BCC). In spite of these promising clinical results; however, there exists a paucity of knowledge on the precise anti-tumor action of IFN-α/β at the cellular and molecular levels in cutaneous malignancies such as SCC, BCC, and melanoma. This review summarizes current knowledge on the extent to which Type I IFN influences proliferation, apoptosis, angiogenesis, and immune function in normal skin, cutaneous SCC, BCC, and melanoma. |
| format | Article |
| id | doaj-art-8ae653c0856048bda5c82e35f9bcba8f |
| institution | OA Journals |
| issn | 1687-6105 1687-6113 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Dermatology Research and Practice |
| spelling | doaj-art-8ae653c0856048bda5c82e35f9bcba8f2025-08-20T02:09:28ZengWileyDermatology Research and Practice1687-61051687-61132014-01-01201410.1155/2014/847545847545Type I Interferons: Key Players in Normal Skin and Select Cutaneous MalignanciesAimen Ismail0Nabiha Yusuf1School of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USADepartment of Dermatology, University of Alabama at Birmingham, VH 566A, 1670 University Boulevard, Birmingham, AL 35294, USAInterferons (IFNs) are a family of naturally existing glycoproteins known for their antiviral activity and their ability to influence the behavior of normal and transformed cell types. Type I Interferons include IFN-α and IFN-β. Currently, IFN-α has numerous approved antitumor applications, including malignant melanoma, in which IFN-α has been shown to increase relapse free survival. Moreover, IFN-α has been successfully used in the intralesional treatment of cutaneous squamous cell carcinoma (SCC) and basal cell carcinoma (BCC). In spite of these promising clinical results; however, there exists a paucity of knowledge on the precise anti-tumor action of IFN-α/β at the cellular and molecular levels in cutaneous malignancies such as SCC, BCC, and melanoma. This review summarizes current knowledge on the extent to which Type I IFN influences proliferation, apoptosis, angiogenesis, and immune function in normal skin, cutaneous SCC, BCC, and melanoma.http://dx.doi.org/10.1155/2014/847545 |
| spellingShingle | Aimen Ismail Nabiha Yusuf Type I Interferons: Key Players in Normal Skin and Select Cutaneous Malignancies Dermatology Research and Practice |
| title | Type I Interferons: Key Players in Normal Skin and Select Cutaneous Malignancies |
| title_full | Type I Interferons: Key Players in Normal Skin and Select Cutaneous Malignancies |
| title_fullStr | Type I Interferons: Key Players in Normal Skin and Select Cutaneous Malignancies |
| title_full_unstemmed | Type I Interferons: Key Players in Normal Skin and Select Cutaneous Malignancies |
| title_short | Type I Interferons: Key Players in Normal Skin and Select Cutaneous Malignancies |
| title_sort | type i interferons key players in normal skin and select cutaneous malignancies |
| url | http://dx.doi.org/10.1155/2014/847545 |
| work_keys_str_mv | AT aimenismail typeiinterferonskeyplayersinnormalskinandselectcutaneousmalignancies AT nabihayusuf typeiinterferonskeyplayersinnormalskinandselectcutaneousmalignancies |