A combinatorial and computational Tandem approach towards a universal therapeutics against ACE2-mediated coronavirus infections

A combinatorial and computational Tandem approach towards a universal therapeutics against ACE2-mediated coronavirus infections

Summary: Angiotensin-converting enzyme 2 (ACE2) receptor plays a pivotal role in the infection of several coronaviruses, including SARS-CoV and SARS-CoV-2. We combined computational and experimental protein engineering approaches to develop ACE2-YHA, a soluble, high-affinity ACE2 decoy with pan-coro...

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Bibliographic Details
Main Authors: Chia Yin Lee, Ching-Wen Huang, Louis De Falco, Jr., Rabiatul Adawiyah Minhat, Aurélien Traversier, Bei Wang, Siti Nazihah Mohd Salleh, Eve Zi Xian Ngoh, Yuling Huang, Jenna Kim, Matthew Zirui Tay, Manuel Rosa-Calatrava, Andrés Pizzorno, Roland G. Huber, Cheng-I Wang
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:iScience
Subjects:
Natural sciences
Biological sciences
Biochemistry
Microbiology
Virology
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004225009484
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