Sympathetic innervation induced by nerve growth factor promotes malignant transformation in gastric cancer

Sympathetic innervation induced by nerve growth factor promotes malignant transformation in gastric cancer

Abstract Sympathetic nerves regulate nearly all human organs. Their peripheral nerves are present in tumor tissue. Activation of the sympathetic nervous system promotes malignant transformation in several cancers. This study aimed to quantify sympathetic nerve density (SND) in gastric cancer and inv...

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Main Authors: Takefumi Itami, Yukinori Kurokawa, Takaomi Hagi, Shinnosuke Nagano, Rennosuke Nakamoto, Yu Kamakura, Tsuyoshi Takahashi, Takuro Saito, Kazuyoshi Yamamoto, Kota Momose, Kotaro Yamashita, Koji Tanaka, Tomoki Makino, Kiyokazu Nakajima, Hidetoshi Eguchi, Yuichiro Doki
Format: Article
Language:English
Published: Nature Portfolio 2025-01-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-025-87492-9
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