Is Biologic Therapy an Effective Tool for Achieving Remission in Severe Asthma? A Retrospective Study in Central Romania
Background: Severe asthma, which is characterized by persistent symptoms despite standard therapies, presents a significant clinical challenge. Biologic therapies targeting specific inflammatory pathways offer a potential avenue for achieving disease remission. This retrospective study evaluates the...
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2025-07-01
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| author | Corina Mărginean Dragoș Huțanu Mara Andreea Vultur Hédi-Katalin Sárközi Edith-Simona Ianoși Maria Beatrice Ianoși Andreea Safta Gabriela Jimborean Corina Eugenia Budin |
| author_facet | Corina Mărginean Dragoș Huțanu Mara Andreea Vultur Hédi-Katalin Sárközi Edith-Simona Ianoși Maria Beatrice Ianoși Andreea Safta Gabriela Jimborean Corina Eugenia Budin |
| author_sort | Corina Mărginean |
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| description | Background: Severe asthma, which is characterized by persistent symptoms despite standard therapies, presents a significant clinical challenge. Biologic therapies targeting specific inflammatory pathways offer a potential avenue for achieving disease remission. This retrospective study evaluates the effectiveness of biologic therapies in achieving remission in severe asthma within a central Romanian cohort. Methods: Forty-eight patients with severe asthma treated with omalizumab, benralizumab, or dupilumab (2020–2025) were assessed. Clinical remission was defined using ACT scores, exacerbation frequency, corticosteroid use, and FEV1. Biological remission was determined using FeNO and eosinophil levels. Statistical analysis was performed to compare treatment outcomes. Results: At 12 months, 75% of patients achieved biological remission, and 75% reached clinical remission criteria. Significant improvements were observed in FEV1 (<i>p</i> < 0.001), eosinophil counts (<i>p</i> < 0.001), and ACT scores (<i>p</i> < 0.001). Complete remission, encompassing clinical, biological, and functional normalization, was observed in 54.2% of patients. Conclusion: Biologic therapies demonstrate promise in inducing comprehensive remission in severe asthma, supporting their role in improving disease control and lung function. Further research with larger cohorts is warranted. |
| format | Article |
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| institution | Kabale University |
| issn | 2075-1729 |
| language | English |
| publishDate | 2025-07-01 |
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| spelling | doaj-art-8acadb8fc1ae4d52ab6bb002c2189c642025-08-20T03:36:21ZengMDPI AGLife2075-17292025-07-01157111310.3390/life15071113Is Biologic Therapy an Effective Tool for Achieving Remission in Severe Asthma? A Retrospective Study in Central RomaniaCorina Mărginean0Dragoș Huțanu1Mara Andreea Vultur2Hédi-Katalin Sárközi3Edith-Simona Ianoși4Maria Beatrice Ianoși5Andreea Safta6Gabriela Jimborean7Corina Eugenia Budin8Oncology and Palliative Care Department, George Emil Palade University of Medicine, Pharmacy, Science and Technology of Târgu Mureș, 540139 Târgu Mureș, RomaniaPulmonology Department, George Emil Palade University of Medicine, Pharmacy, Science and Technology of Târgu Mureș, 540139 Târgu Mureș, RomaniaPulmonology Department, George Emil Palade University of Medicine, Pharmacy, Science and Technology of Târgu Mureș, 540139 Târgu Mureș, RomaniaPulmonology Department, George Emil Palade University of Medicine, Pharmacy, Science and Technology of Târgu Mureș, 540139 Târgu Mureș, RomaniaPulmonology Department, George Emil Palade University of Medicine, Pharmacy, Science and Technology of Târgu Mureș, 540139 Târgu Mureș, RomaniaPulmonology Clinic, Mureș County Clinical Hospital, Târgu Mureș, 540011 Târgu Mureș, RomaniaPulmonology Clinic, Mureș County Clinical Hospital, Târgu Mureș, 540011 Târgu Mureș, RomaniaPulmonology Department, George Emil Palade University of Medicine, Pharmacy, Science and Technology of Târgu Mureș, 540139 Târgu Mureș, RomaniaPathophysiology Department, George Emil Palade University of Medicine, Pharmacy, Science and Technology of Târgu Mureș, 540139 Târgu Mureș, RomaniaBackground: Severe asthma, which is characterized by persistent symptoms despite standard therapies, presents a significant clinical challenge. Biologic therapies targeting specific inflammatory pathways offer a potential avenue for achieving disease remission. This retrospective study evaluates the effectiveness of biologic therapies in achieving remission in severe asthma within a central Romanian cohort. Methods: Forty-eight patients with severe asthma treated with omalizumab, benralizumab, or dupilumab (2020–2025) were assessed. Clinical remission was defined using ACT scores, exacerbation frequency, corticosteroid use, and FEV1. Biological remission was determined using FeNO and eosinophil levels. Statistical analysis was performed to compare treatment outcomes. Results: At 12 months, 75% of patients achieved biological remission, and 75% reached clinical remission criteria. Significant improvements were observed in FEV1 (<i>p</i> < 0.001), eosinophil counts (<i>p</i> < 0.001), and ACT scores (<i>p</i> < 0.001). Complete remission, encompassing clinical, biological, and functional normalization, was observed in 54.2% of patients. Conclusion: Biologic therapies demonstrate promise in inducing comprehensive remission in severe asthma, supporting their role in improving disease control and lung function. Further research with larger cohorts is warranted.https://www.mdpi.com/2075-1729/15/7/1113severe asthmabiologic therapyasthma remission |
| spellingShingle | Corina Mărginean Dragoș Huțanu Mara Andreea Vultur Hédi-Katalin Sárközi Edith-Simona Ianoși Maria Beatrice Ianoși Andreea Safta Gabriela Jimborean Corina Eugenia Budin Is Biologic Therapy an Effective Tool for Achieving Remission in Severe Asthma? A Retrospective Study in Central Romania Life severe asthma biologic therapy asthma remission |
| title | Is Biologic Therapy an Effective Tool for Achieving Remission in Severe Asthma? A Retrospective Study in Central Romania |
| title_full | Is Biologic Therapy an Effective Tool for Achieving Remission in Severe Asthma? A Retrospective Study in Central Romania |
| title_fullStr | Is Biologic Therapy an Effective Tool for Achieving Remission in Severe Asthma? A Retrospective Study in Central Romania |
| title_full_unstemmed | Is Biologic Therapy an Effective Tool for Achieving Remission in Severe Asthma? A Retrospective Study in Central Romania |
| title_short | Is Biologic Therapy an Effective Tool for Achieving Remission in Severe Asthma? A Retrospective Study in Central Romania |
| title_sort | is biologic therapy an effective tool for achieving remission in severe asthma a retrospective study in central romania |
| topic | severe asthma biologic therapy asthma remission |
| url | https://www.mdpi.com/2075-1729/15/7/1113 |
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