Allosteric activation of the SPRTN protease by ubiquitin maintains genome stability

Allosteric activation of the SPRTN protease by ubiquitin maintains genome stability

Abstract The DNA-dependent protease SPRTN maintains genome stability by degrading toxic DNA-protein crosslinks (DPCs). To understand how SPRTN’s promiscuous protease activity is confined to cleavage of crosslinked proteins, we reconstitute the repair of DPCs including their modification with SUMO an...

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Main Authors: Sophie Dürauer, Hyun-Seo Kang, Christian Wiebeler, Yuka Machida, Dina S. Schnapka, Denitsa Yaneva, Christian Renz, Maximilian J. Götz, Pedro Weickert, Abigail C. Major, Aldwin S. Rahmanto, Sophie M. Gutenthaler-Tietze, Lena J. Daumann, Petra Beli, Helle D. Ulrich, Michael Sattler, Yuichi J. Machida, Nadine Schwierz, Julian Stingele
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-61224-z
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