Bacteriophages and Their Immunological Applications against Infectious Threats
Bacteriophage therapy dates back almost a century, but the discovery of antibiotics led to a rapid decline in the interests and investments within this field of research. Recently, the novel threat of multidrug-resistant bacteria highlighted the alarming drop in research and development of new antib...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2017/3780697 |
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| _version_ | 1850211967949602816 |
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| author | Elena Criscuolo Sara Spadini Jacopo Lamanna Mattia Ferro Roberto Burioni |
| author_facet | Elena Criscuolo Sara Spadini Jacopo Lamanna Mattia Ferro Roberto Burioni |
| author_sort | Elena Criscuolo |
| collection | DOAJ |
| description | Bacteriophage therapy dates back almost a century, but the discovery of antibiotics led to a rapid decline in the interests and investments within this field of research. Recently, the novel threat of multidrug-resistant bacteria highlighted the alarming drop in research and development of new antibiotics: 16 molecules were discovered during 1983–87, 10 new therapeutics during the nineties, and only 5 between 2003 and 2007. Phages are therefore being reconsidered as alternative therapeutics. Phage display technique has proved to be extremely promising for the identification of effective antibodies directed against pathogens, as well as for vaccine development. At the same time, conventional phage therapy uses lytic bacteriophages for treatment of infections and recent clinical trials have shown great potential. Moreover, several other approaches have been developed in vitro and in vivo using phage-derived proteins as antibacterial agents. Finally, their use has also been widely considered for public health surveillance, as biosensor phages can be used to detect food and water contaminations and prevent bacterial epidemics. These novel approaches strongly promote the idea that phages and their proteins can be exploited as an effective weapon in the near future, especially in a world which is on the brink of a “postantibiotic era.” |
| format | Article |
| id | doaj-art-8aca3b86c4a84e3490bd72c8d83d5dd5 |
| institution | OA Journals |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-8aca3b86c4a84e3490bd72c8d83d5dd52025-08-20T02:09:26ZengWileyJournal of Immunology Research2314-88612314-71562017-01-01201710.1155/2017/37806973780697Bacteriophages and Their Immunological Applications against Infectious ThreatsElena Criscuolo0Sara Spadini1Jacopo Lamanna2Mattia Ferro3Roberto Burioni4Microbiology and Virology Unit, Vita-Salute San Raffaele University, Milan, ItalyVita-Salute San Raffaele University, Milan, ItalyVita-Salute San Raffaele University, Milan, ItalyVita-Salute San Raffaele University, Milan, ItalyMicrobiology and Virology Unit, Vita-Salute San Raffaele University, Milan, ItalyBacteriophage therapy dates back almost a century, but the discovery of antibiotics led to a rapid decline in the interests and investments within this field of research. Recently, the novel threat of multidrug-resistant bacteria highlighted the alarming drop in research and development of new antibiotics: 16 molecules were discovered during 1983–87, 10 new therapeutics during the nineties, and only 5 between 2003 and 2007. Phages are therefore being reconsidered as alternative therapeutics. Phage display technique has proved to be extremely promising for the identification of effective antibodies directed against pathogens, as well as for vaccine development. At the same time, conventional phage therapy uses lytic bacteriophages for treatment of infections and recent clinical trials have shown great potential. Moreover, several other approaches have been developed in vitro and in vivo using phage-derived proteins as antibacterial agents. Finally, their use has also been widely considered for public health surveillance, as biosensor phages can be used to detect food and water contaminations and prevent bacterial epidemics. These novel approaches strongly promote the idea that phages and their proteins can be exploited as an effective weapon in the near future, especially in a world which is on the brink of a “postantibiotic era.”http://dx.doi.org/10.1155/2017/3780697 |
| spellingShingle | Elena Criscuolo Sara Spadini Jacopo Lamanna Mattia Ferro Roberto Burioni Bacteriophages and Their Immunological Applications against Infectious Threats Journal of Immunology Research |
| title | Bacteriophages and Their Immunological Applications against Infectious Threats |
| title_full | Bacteriophages and Their Immunological Applications against Infectious Threats |
| title_fullStr | Bacteriophages and Their Immunological Applications against Infectious Threats |
| title_full_unstemmed | Bacteriophages and Their Immunological Applications against Infectious Threats |
| title_short | Bacteriophages and Their Immunological Applications against Infectious Threats |
| title_sort | bacteriophages and their immunological applications against infectious threats |
| url | http://dx.doi.org/10.1155/2017/3780697 |
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