Quantification of paravertebral cross-sectional muscle areas and fatty degeneration and their correlation with clinical parameters in ankylosing spondylitis: a comprehensive analysis
Aims: Ankylosing spondylitis (AS) is a chronic disease characterized by inflammation of the spine and joints. This study aimed to examine the multifidus (MF) and erector spinae (ES) muscles in AS patients using magnetic resonance imaging (MRI), and to evaluate the clinical implications of muscle fin...
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| Format: | Article |
| Language: | English |
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Sociedade Portuguesa de Reumatologia
2025-03-01
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| Series: | ARP Rheumatology |
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| Online Access: | http://www.arprheumatology.com/files/article/1572_quantification_of_paravertebra_file.pdf |
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| author | Selçuk Akkaya Gonca Sağlam Akkaya Serpil Demirulus Hanife Baykal Şahin Gamze Kılıç Erhan Çapkın Murat Karkucak |
| author_facet | Selçuk Akkaya Gonca Sağlam Akkaya Serpil Demirulus Hanife Baykal Şahin Gamze Kılıç Erhan Çapkın Murat Karkucak |
| author_sort | Selçuk Akkaya |
| collection | DOAJ |
| description | Aims: Ankylosing spondylitis (AS) is a chronic disease characterized by inflammation of the spine and joints. This study aimed to examine the multifidus (MF) and erector spinae (ES) muscles in AS patients using magnetic resonance imaging (MRI), and to evaluate the clinical implications of muscle findings.
Methods: This study included 43 patients and 40 matched controls. The total (TCSA), functional (FCSA), relative CSAs, and ratios of MF and ES muscles were compared between the groups. The Visual Analog Scale, Bath Ankylosing Spondylitis Metrology Index (BASMI), Bath Ankylosing Spondylitis Functional Index (BASFI), Ankylosing Spondylitis Disease Activity Score with CRP, Ankylosing Spondylitis Disease Activity Score with ESR, Bath Ankylosing Spondylitis Activity Index, and Ankylosing Spondylitis Quality of Life Questionnaire (ASQoL) scores of AS patients were recorded. Comparisons between the two groups were made using the Student's t-test and the Mann-Whitney U test.
Results: The TCSAs of the MF and ES were similar in the two groups. In contrast, MF relative FCSA (p = 0.003), ES relative FCSA (p < 0.001), ES FCSA (p = 0.017), MF FCSA/TCSA (p < 0.001), and ES FCSA/TCSA (p < 0.001) were decreased in AS patients. ES FCSA/TCSA was negatively correlated with BASMI (r = - 0.369, p = 0.015), while MF FCSA/TCSA was negatively correlated with BASMI, BASFI, and ASQoL (r = - 0.395, p = 0.009; r = - 0.321 p = 0.036; r = - 0.387, p = 0.010, respectively).
Conclusions: The paravertebral muscle morphology significantly deteriorates in AS patients, exhibiting decreased functional muscle areas and increased fatty degeneration. |
| format | Article |
| id | doaj-art-8ac9ad11bb3c43ee84943dbaa29df0dc |
| institution | DOAJ |
| issn | 2795-4552 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Sociedade Portuguesa de Reumatologia |
| record_format | Article |
| series | ARP Rheumatology |
| spelling | doaj-art-8ac9ad11bb3c43ee84943dbaa29df0dc2025-08-20T03:15:47ZengSociedade Portuguesa de ReumatologiaARP Rheumatology2795-45522025-03-01202511319AO240273Quantification of paravertebral cross-sectional muscle areas and fatty degeneration and their correlation with clinical parameters in ankylosing spondylitis: a comprehensive analysisSelçuk Akkaya0Gonca Sağlam Akkaya1Serpil Demirulus2Hanife Baykal Şahin3Gamze Kılıç4Erhan Çapkın5Murat Karkucak6Karadeniz Technical UniversityKaradeniz Technical UniversityKaradeniz Technical UniversityKaradeniz Technical UniversityKaradeniz Technical UniversityKaradeniz Technical UniversityKaradeniz Technical UniversityAims: Ankylosing spondylitis (AS) is a chronic disease characterized by inflammation of the spine and joints. This study aimed to examine the multifidus (MF) and erector spinae (ES) muscles in AS patients using magnetic resonance imaging (MRI), and to evaluate the clinical implications of muscle findings. Methods: This study included 43 patients and 40 matched controls. The total (TCSA), functional (FCSA), relative CSAs, and ratios of MF and ES muscles were compared between the groups. The Visual Analog Scale, Bath Ankylosing Spondylitis Metrology Index (BASMI), Bath Ankylosing Spondylitis Functional Index (BASFI), Ankylosing Spondylitis Disease Activity Score with CRP, Ankylosing Spondylitis Disease Activity Score with ESR, Bath Ankylosing Spondylitis Activity Index, and Ankylosing Spondylitis Quality of Life Questionnaire (ASQoL) scores of AS patients were recorded. Comparisons between the two groups were made using the Student's t-test and the Mann-Whitney U test. Results: The TCSAs of the MF and ES were similar in the two groups. In contrast, MF relative FCSA (p = 0.003), ES relative FCSA (p < 0.001), ES FCSA (p = 0.017), MF FCSA/TCSA (p < 0.001), and ES FCSA/TCSA (p < 0.001) were decreased in AS patients. ES FCSA/TCSA was negatively correlated with BASMI (r = - 0.369, p = 0.015), while MF FCSA/TCSA was negatively correlated with BASMI, BASFI, and ASQoL (r = - 0.395, p = 0.009; r = - 0.321 p = 0.036; r = - 0.387, p = 0.010, respectively). Conclusions: The paravertebral muscle morphology significantly deteriorates in AS patients, exhibiting decreased functional muscle areas and increased fatty degeneration.http://www.arprheumatology.com/files/article/1572_quantification_of_paravertebra_file.pdfchronic pain syndromesmuscleankylosing spondylitisspondyloarthropathies (including psoriatic arthritis)spinal disorders |
| spellingShingle | Selçuk Akkaya Gonca Sağlam Akkaya Serpil Demirulus Hanife Baykal Şahin Gamze Kılıç Erhan Çapkın Murat Karkucak Quantification of paravertebral cross-sectional muscle areas and fatty degeneration and their correlation with clinical parameters in ankylosing spondylitis: a comprehensive analysis ARP Rheumatology chronic pain syndromes muscle ankylosing spondylitis spondyloarthropathies (including psoriatic arthritis) spinal disorders |
| title | Quantification of paravertebral cross-sectional muscle areas and fatty degeneration and their correlation with clinical parameters in ankylosing spondylitis: a comprehensive analysis |
| title_full | Quantification of paravertebral cross-sectional muscle areas and fatty degeneration and their correlation with clinical parameters in ankylosing spondylitis: a comprehensive analysis |
| title_fullStr | Quantification of paravertebral cross-sectional muscle areas and fatty degeneration and their correlation with clinical parameters in ankylosing spondylitis: a comprehensive analysis |
| title_full_unstemmed | Quantification of paravertebral cross-sectional muscle areas and fatty degeneration and their correlation with clinical parameters in ankylosing spondylitis: a comprehensive analysis |
| title_short | Quantification of paravertebral cross-sectional muscle areas and fatty degeneration and their correlation with clinical parameters in ankylosing spondylitis: a comprehensive analysis |
| title_sort | quantification of paravertebral cross sectional muscle areas and fatty degeneration and their correlation with clinical parameters in ankylosing spondylitis a comprehensive analysis |
| topic | chronic pain syndromes muscle ankylosing spondylitis spondyloarthropathies (including psoriatic arthritis) spinal disorders |
| url | http://www.arprheumatology.com/files/article/1572_quantification_of_paravertebra_file.pdf |
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